Search results for "SLI"
showing 10 items of 1729 documents
Optisko metožu un ierīču izstrāde kardiovaskulārā stāvokļa kontrolei reālā laikā
2013
Elektroniskā versija nesatur pielikumus
Marcadores de inflamación e insulinorresistencia en la hiperlipemia familiar combinada
2014
La hiperlipemia familiar combinada (HFC) es un modelo genético de dislipemia mixta con resistencia a la insulina (RI) y elevado riesgo de cardiopatía isquémica por el desarrollo precoz de arteriosclerosis. La RI es independiente del grado de obesidad y del fenotipo lipoproteico. Constituye, además, factor de riesgo cardiovascular en estos pacientes. Actualmente existe una gran evidencia de que en el desarrollo y progresión de la aterosclerosis subyacen mecanismos inmunológicos e inflamatorios. Algunos estudios han demostrado que proteínas de fase aguda y algunas interleucinas fueron factores predictivos de progresión y gravedad de enfermedad coronaria. Recientemente, en modelos animales y h…
Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea : data from t…
2020
Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP …
Ezetimibe, cardiovascular risk and atherogenic dyslipidaemia.
2010
Ezetimibe is a selective cholesterol absorption inhibitor with an excellent side-effect profile, able to reduce low-density lipoprotein (LDL) cholesterol by 15-25% from baseline in monotherapy and on top of statins and fibrates. Yet, it seems that ezetimibe produces quantitative rather than qualitative changes in LDL, with small net effects on atherogenic dyslipidaemia. This is supported by findings from the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) study on atherosclerosis progression, where the addition of ezetimibe to simvastatin in patients with heterozygous familial hypercholesterolaemia did not affect the mean change in carotid int…
Lipoproteins and Cardiovascular Disease: An Update on the Clinical Significance of Atherogenic Small, Dense LDL and New Therapeutical Options
2021
Dyslipidemia is a potent risk factor for the genesis and progression of cardiovascular disease (CVD), and both the concentration and type of low-density lipoproteins (LDL) augment this association. The small, dense LDL (sdLDL) subfraction is the subtype which is most strongly predictive of atherosclerosis and cardiovascular events. In addition to the traditionally available lipid-lowering treatment options, certain novel therapies have been shown to favorably impact sdLDL, among them the antidiabetic class of agents known as glucagon-like peptide 1 receptor agonists (GLP1-RAs). These drugs seem to alter the pathophysiologic mechanisms responsible for the formation and accumulation of athero…
Treatment options for managing atherogenic dyslipidemia and fatty liver disease
2014
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries with up to 30% of the population affected. Since NAFLD is associated with an increased risk of cardiovascular (CV) disease, these patients should be stratified for CV risk factors, including atherogenic dyslipidemia, and managed accordingly. Lifestyle modifications represent an effective treatment for NAFLD, since most patients are overweight or obese. Also, promising, but not conclusive, results are available for current pharmacologic treatment. Drugs potentially effective against NAFLD include insulin sensitisers as well as fibrates and omega-3 polyunsaturated fatty acids, whil…
Obesity and cardiovascular risk
2018
: Obesity is a key factor for cardiovascular diseases and complications. Obesity is associated with hypertension, dyslipidemia and type II diabetes, which are the major predictors of cardiovascular disease in the future. It predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke that are the main causes of cardiovascular hospitalization and mortality. As obesity and the cardiovascular effects on the vessels and the heart start early in life, even from childhood, it is important for health policies to prevent obesity very early before the disease manifestation emerge. Key roles in the prevention are strategies to increase physical exercise,…
Estudio de la variación a largo plazo de los parámetros bioquímicos metabólicos en pacientes con obesidad mórbida e intervenidos mediante bypass gást…
2015
INTRODUCCIÓN La Obesidad es ya uno de los mayores problemas de salud pública en los países occidentales y se prevé que en un futuro cercano sea una verdadera epidemia. La naturaleza de este problema no es estética, como es habitual que se valore en nuestro entorno social. Tiene un sinfín de repercusiones. Empezando por las comorbilidades metabólicas que la acompañan, las complicaciones osteoarticulares que desencadena o simplemente el rechazo social que muchas veces genera. Todo ello sumado, da lugar a una pérdida importante de esperanza de vida y de la calidad de la misma. La consecuencia fundamental de la Obesidad y que provoca el mayor riesgo de morbilidad y, sobre todo de mortalidad, es…
Oxidative stress and small, dense low-density lipoproteins: current and future perspectives
2019
Small, dense low-density lipoproteins (LDLs) are more susceptible to oxidation than their larger, more buoyant counterparts and therefore the biological modification of these LDL particles may, in part, be responsible for their atherogenic properties. Kotani et al. found that at multiple regression analysis there was an independent and significant inverse correlation between the mean LDL particle size and the oxidative stress status; notably, the authors adjusted not only for the traditional cardiovascular risk factors, but also for drug treatments. Higher levels of small, dense LDL concentrations significantly contribute to atherosclerosis, and lipoprotein size and subfractions may refine …
Cerība un tās nozīme smagi slimu pacientu aprūpē
2021
Jau izsenis cerības jēdziens ir ticis aktīvi locīts daudzu tautu kultūrās. Tā izpratne un lietojums dažādos laikos un dažādās kultūrās gan bijis visai atšķirīgs. Sākotnēji apspriesta teologu vidū, cerība saistījusi arī filozofu prātus, bet līdz ar zinātņu (it īpaši veselības zinātņu) attīstību aizvien lielāka nozīme tai piešķirta arī zinātnieku, sevišķi darbojošos medicīnas jomā, aprindās. Apjomīgais, ar cerību saistītais, pētījumu klāsts liecina, ka arī šodien šī interese nav mazinājusies. Gluži otrādi, attīstoties medicīnas un humanitāro zinātņu nozarēm, cerības kā būtiska resursu avota aktualitāte ir tikai augusi, kļūstot par visnotaļ aizraujošu sava veida “izpētes objektu” arī plašajā p…