Search results for "SLI"
showing 10 items of 1729 documents
Microstructure and fabric development in ice: Lessons learned from in situ experiments and implications for understanding rock evolution
2014
Abstract In this contribution we present a review of the evolution of microstructures and fabric in ice. Based on the review we show the potential use of ice as an analogue for rocks by considering selected examples that can be related to quartz-rich rocks. Advances in our understanding of the plasticity of ice have come from experimental investigations that clearly show that plastic deformation of polycrystalline ice is initially produced by basal slip. Interaction of dislocations play an essential role for dynamic recrystallization processes involving grain nucleation and grain-boundary migration during the steady-state flow of ice. To support this review we describe deformation in polycr…
Deformation of melt-bearing systems—insight from in situ grain-scale analogue experiments
2005
Abstract The deformation behaviour of partially molten rocks was investigated using in situ analogue experiments with norcamphor+ethanol, as well as partially molten KNO 3 +LiNO 3 . Three general deformation regimes could be distinguished during bulk pure shear deformation. In regime I, above ca. 8–10 vol.% liquid (melt) fraction ( ϕ bulk ), deformation is by compaction, distributed granular flow, and grain boundary sliding (GBS). At ϕ bulk ϕ bulk (regime III), grains form a coherent framework that deforms by grain boundary migration accommodated dislocation creep, associated with efficient segregation of remaining liquid. The transition liquid fraction between regimes I and II ( ϕ LT ) dep…
Shear banding mechanism of plastic deformation in LiF irradiated with swift heavy ions
2012
The effect of ion irradiation on the behavior of plastic deformation at micro- and nanoindentation on (001) face of LiF has been investigated. The irradiation was performed using heavy ions (U, Au, Ti and S) with energy in the range from 3 MeV to 2 GeV at fluences up to 5x1013 ions/cm2. In non-irradiated LiF, the indentation produces dislocation gliding on the {110} planes along the and directions. At high fluence irradiation, the resource of the dislocation slip along the preferable directions becomes exhausted due to immobilization of dislocations by radiation defects and their aggregates. The present study demonstrates the change of the mechanism of plastic deformation from homogenous di…
Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications.
2016
To optimally exploit the potential of (tumor-) targeted nanomedicines, platform technologies are needed in which physicochemical and pharmaceutical properties can be tailored according to specific medical needs and applications. We here systematically customized the properties of core-crosslinked polymeric micelles (CCPM). The micelles were based on mPEG-b-pHPMAmLacn (i.e. methoxy poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl) methacrylamide-lactate]), similar to the block copolymer composition employed in CriPec® docetaxel, which is currently in phase I clinical trials. The CCPM platform was tailored with regard to size (30 to 100 nm), nanocarrier degradation (1 month to 1 year) and drug…
Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation
2015
Polymeric micelles (PM) are extensively used to improve the delivery of hydrophobic drugs. Many different PM have been designed and evaluated over the years, and some of them have steadily progressed through clinical trials. Increasing evidence suggests, however, that for prolonged circulation times and for efficient EPR-mediated drug targeting to tumors and to sites of inflammation, PM need to be stabilized, to prevent premature disintegration. Core-crosslinking is among the most popular methods to improve the in vivo stability of PM, and a number of core-crosslinked polymeric micelles (CCPM) have demonstrated promising efficacy in animal models. The latter is particularly true for CCPM in…
Inclisiran: a small interfering RNA strategy targeting PCSK9 to treat hypercholesterolemia
2022
Introduction: Inclisiran is a novel posttranscriptional gene silencing therapy that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) synthesis by RNA interference and has a potent, dose-dependent, durable effect in lowering LDL-C, and therefore is an effective drug to treat dyslipidemia, reducing the risk for acute cardiovascular (CV) events. It is safe and well-tolerated. Areas covered: This paper aims to review the mechanism of action of inclisiran while evaluating its efficacy and safety in the treatment of dyslipidemia from data of the clinical trials in the ORION program. Expert opinion: Data from the clinical trials in the ORION program demonstrated efficacy and safety o…
Herbal hepatotoxicity: a hidden epidemic
2011
Complementary and alternative therapies, including herbal products, have become increasingly popular in the general population and among patients and physicians. Regulations and pharmacovigilance regarding herbal drugs are still incomplete and need to be improved. In fact, herbals are commonly marketed on the Internet, and in many countries they are sold as food supplements, which are beyond the control of drug regulatory agencies. In Europe and the U.S., reports of hepatotoxicity from these products, including those advertised for liver diseases, are accumulating. Many herbal drugs are also commonly used in children, and in women during pregnancy and lactation, because they are believed to…
Impact of reslizumab on outcomes of severe asthmatic patients: current perspectives.
2018
Approximately 5%-10% of asthmatics suffer from severe asthma. New biological treatments represent a great opportunity to reduce asthma burden and to improve asthma patients' lives. Reslizumab will soon be available in several European countries. This anti-IL-5 IgG4/kappa monoclonal antibody, administered intravenously at a dose of 3 mg/kg over 20-50 minutes every 4 weeks, has been shown to be safe and effective in patients with 400 eosinophils/mu L or more in their peripheral blood. The clinical effects in reducing asthma exacerbations and in improving the quality of life and lung function are clear, but further research is needed to determine the best biological compound for a specific clu…
Nutraceuticals and dyslipidaemia: Beyond the common therapeutics
2014
Dyslipidaemia accelerates the atherosclerotic process and its morbid consequences; statins represent the evidence-based treatment of choice for reducing low-density lipoprotein cholesterol levels and decreasing cardiovascular events. Unfortunately, statins are frequently not available for several reasons, including intolerance, side effects or, simply, patient preference. Nutraceuticals and functional food ingredients that are beneficial to vascular health may represent useful compounds that are able to reduce the overall cardiovascular risk induced by dyslipidaemia by acting parallel to statins or as adjuvants in case of failure or in situations where statins cannot be used. The mechanisms…
Consenso Delphi sobre el diagnóstico y manejo de la dislipidemia en pacientes con enfermedad renal crónica: análisis post-hoc del estudio DIANA
2016
Resumen Antecedentes y objetivos: Este estudio post hoc analizó la percepción de la importancia de la enfermedad renal crónica (ERC) en el cribado de la dislipidemia y en la elección del tratamiento con estatinas entre médicos de Atención Primaria (MAP) y otras especialidades mediante cuestionario Delphi. Métodos: El cuestionario incluyó 4 bloques de preguntas alrededor del paciente dislipémico con alteración del metabolismo hidrocarbonado. Aquí se presentan los resultados relacionados con la consideración de la ERC en el cribado y la elección de la estatina. Resultados: De los 497 expertos incluidos, el 58% eran MAP y el 42%, especialistas (35, el 7%, nefrólogos). Hubo consenso en realizar…