Search results for "SMAD"
showing 10 items of 81 documents
Coinfection patterns of two marine apicomplexans are not associated with genetic diversity of their polychaete host.
2022
Coinfections of two or more parasites within one host are more of a rule than an exception in nature. Interactions between coinfecting parasites can greatly affect their abundance and prevalence. Characteristics of the host, such as genetic diversity, can also affect the infection dynamics of coinfecting parasites. Here we investigate for the first time the association of coinfection patterns of two marine apicomplexans, Rhytidocystis sp. and Selenidium pygospionis, with the genetic diversity of their host, the polychaete Pygospio elegans, from natural populations. Host genetic diversity was determined with seven microsatellite loci and summarized as allelic richness, inbreeding coefficient…
Synthesis and physico-chemical characterization of gold nanoparticles softly coated by AOT
2006
Size-controlled gold nanoparticles/surfactant stable systems were prepared by the combined action of the solvated metal atom dispersion (SMAD) technique and confinement in anhydrous sodium bis(2-ethylhexyl)sulfosuccinate (AOT) micellar solution. From liquid samples, by evaporation of the organic solvent, solid gold nanoparticle-surfactant liquid crystals composites were obtained. Sample characterization was performed by X-ray diffraction (SAXS and WAXS), XPS spectroscopy and UV-vis-NIR spectroscopy. All experimental data consistently revealed the coexistence of two gold nanoparticle size populations: bigger nanoparticles (size 20-50 angstrom) and smaller ones (size of few angstrom). The two…
Differentiation of Murine C2C12 Myoblasts Strongly Reduces the Effects of Myostatin on Intracellular Signaling
2020
Alongside in vivo models, a simpler and more mechanistic approach is required to study the effects of myostatin on skeletal muscle because myostatin is an important negative regulator of muscle size. In this study, myostatin was administered to murine (C2C12) and human (CHQ) myoblasts and myotubes. Canonical and noncanonical signaling downstream to myostatin, related ligands, and their receptor were analyzed. The effects of tumorkines were analyzed after coculture of C2C12 and colon cancer-C26 cells. The effects of myostatin on canonical and noncanonical signaling were strongly reduced in C2C12 cells after differentiation. This may be explained by increased follistatin, an endogenous blocke…
The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A P…
2022
The pathobiology of ascending aorta aneurysms (AAA) onset and progression is not well understood and only partially characterized. AAA are also complicated in case of bicuspid aorta valve (BAV) anatomy. There is emerging evidence about the crucial role of endothelium-related pathways, which show in AAA an altered expression and function. Here, we examined the involvement of ERG-related pathways in the differential progression of disease in aortic tissues from patients having a BAV or tricuspid aorta valve (TAV) with or without AAA. Our findings identified ERG as a novel endothelial-specific regulator of TGF-β-SMAD, Notch, and NO pathways, by modulating a differential fibrotic or calcified A…
Glena Domena metodes izmantošana pirmsskolas vecuma bērniem ar smagiem garīgās attīstības traucējumiem motorikas pilnveidošanai
2019
Diplomdarbā “Glena Domena metodes izmantošana pirmsskolas vecuma bērniem ar smagiem garīgās attīstības traucējumiem motorikas pilnveidošanai” autore Ilona Muižniece izmanto Glena Domena (Glenn Doman) un “Cilvēka potenciālo spēju īstenošanas” institūtu izveidotās metodes motorikas attīstības programmu pirmsskolas vecuma bērniem. Darba ievadā ir aprakstīta tēmas aktualitāte, ir izvirzīta pētījuma hipotēze, pētījuma mērķis un uzdevumi, pētījuma objekts, pētījuma priekšmets, kā arī pētījuma problēma, metodes un pētījuma bāze. Pētījuma teorētiskajā daļā ir bērnu ar smagiem garīgās attīstības traucējumiem raksturojums. Darba empīriskajā daļā ir aprakstīta pētījuma gaita, aprakstīta pētījumā iesai…
Trepānbiopsijas histoloģiskās atradnes korelācija ar izmaiņām perifērajās asinīs limfomas pacientiem
2019
Kancerogēnais process cilvēka organismā tieši ietekmē cilvēka dzīves kvalitāti, sociālo dzīvi, radot ne tikai veselības problēmas, bet arī pārmērīgu psihoemocionālo spriedzi, ar kuru ne katrs indivīds var tikt galā. Limfoma ir ļaundabīga, heterogēna limfātiskas sistēmas neoplāzija. Limfoma skar jebkura vecuma cilvēkus tā var attīstīties gan bērniem, gan pieaugušiem. Slimību profilakses un kontroles centrs 2019. gadā publicēja datus par iedzīvotāju mirstības cēloņiem, mirušo pacientu skaits limfomas dēļ veidoja 124. Ne-Hodžkinas limfomas pacientu skaits bija 112 jeb 90% savukārt Hodžkinas limfomas pacientu skaits bija 12 jeb 9,7%. Pacientu skaits, vecuma grupā (> 60 gadi) veidoja 102 jeb 82%…
Psichiatrija: speciālā daļa [Psihiatrija...]
1929
Galvas smadzeņu audzēju radioloģisko un morfoloģisko korelāciju novērtēšanas pētījums
2017
Primāro galvas smadzeņu (GS) audzēju incidence pēdējās divās dekādēs ir pieaugusi par 25%. GS audzēju diagnostikā ir izmantojamas vairākas metodes, starp kurām svarīgākā ir magnētiskā rezonanse, datortomogrāfija, pozitrona emisijas tomogrāfija, tomēr zelta standarts ir histopatoloģiskā izmeklēšana, kas ir invazīvā metode. Tāpēc pētījumā tika meklētas morfoloģiskās un radioloģiskās korelācijas, kas varētu liecināt par dažādiem primārajiem GS audzēju veidiem, lai turpmāk, diagnosticējot GS audzēju, varētu klīniski radioloģisko ainu korelēt ar audzēja iespējamo morfoloģiju jau pirms histopatoloģiskās izmeklēšanas. Pētījuma mērķis ir novērtēt galvas smadzeņu audzēju radioloģiskās un morfoloģisk…
Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25− T Cells
2007
Abstract Chronic inflammatory diseases may develop when regulatory T cells (Tregs) fail to control the balance between tolerance and immunity. Alternatively, activated immune cells might prevent the induction or activation of Tregs in such diseases. In this study, we demonstrate that trans-signaling into T cells via the soluble IL-6 receptor completely abrogates the de novo induction of adaptive Tregs. Mechanistically, IL-6 trans-signaling augmented the expression of the TGF-β signaling inhibitor SMAD7. Consequently, SMAD7 overexpression in T cells using newly created transgenic mice rendered CD4+CD25− T cells resistant to the induction of FoxP3. Finally, IL-6 trans-signaling inhibited Treg…
Role of Smads in respiratory disease pathogenesis
2008
Transforming Growth Factor beta (TGFβ) cytokine plays an important role in normal pulmonary morphogenesis and function as well as in the pathogenesis of lung diseases. The principal signaling pathway downstream to activate TGFβ is the Smad pathway. Even though many studies have focused on Smads’ structural features and pathway, less is known about the possible relationship between protein and mRNA expression of Smads and lung diseases. This review will focus on Smads and sum up what is know about their role in some respiratory diseases: COPD,asthma end fibrosis