Search results for "SMIS"
showing 10 items of 2316 documents
Statistical Explorations and Univariate Timeseries Analysis on COVID-19 Datasets to Understand the Trend of Disease Spreading and Death
2020
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Lack of evidence of mimivirus replication in human PBMCs
2018
The Acanthamoeba polyphaga mimivirus (APMV) was first isolated during a pneumonia outbreak in Bradford, England, and since its discovery many research groups devoted efforts to understand whether this virus could be associated to human diseases, in particular clinical signs and symptoms of pneumonia. In 2013, we observed cytopathic effect in amoebas (rounding and lysis) inoculated with APMV inoculated PBMCs (peripheral blood mononuclear cell) extracts, and at that point we interpreted those results as mimivirus replication in human PBMCs. Based on these results we decided to further investigate APMV replication in human PBMCs, by transmission electron microscopy (TEM) and qPCR. No viral fac…
Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes
2019
Summary Some viruses are released from cells as pools of membrane-associated virions. By increasing the multiplicity of infection (MOI), this type of collective dispersal could favor viral cooperation, but also the emergence of cheater-like viruses such as defective interfering particles. To better understand this process, we examined the genetic diversity of membrane-associated coxsackievirus infectious units. We find that infected cells release membranous structures (including vesicles) that contain 8–21 infectious particles on average. However, in most cases (62%–93%), these structures do not promote the co-transmission of different viral genetic variants present in a cell. Furthermore, …
Modulation of Hippocampal Circuits by Muscarinic and Nicotinic Receptors
2017
This article provides a review of the effects of activation of muscarinic and nicotinic receptors on the physiological properties of circuits in the hippocampal formation. Previous articles have described detailed computational hypotheses about the role of cholinergic neuromodulation in enhancing the dynamics for encoding in cortical structures and the role of reduced cholinergic modulation in allowing consolidation of previously encoded information. This article will focus on addressing the broad scope of different modulatory effects observed within hippocampal circuits, highlighting the heterogeneity of cholinergic modulation in terms of the physiological effects of activation of muscarin…
More than a pore: How voltage-gated calcium channels act on different levels of neuronal communication regulation.
2021
ABSTRACT Voltage-gated calcium channels (VGCCs) represent key regulators of the calcium influx through the plasma membrane of excitable cells, like neurons. Activated by the depolarization of the membrane, the opening of VGCCs induces very transient and local changes in the intracellular calcium concentration, known as calcium nanodomains, that in turn trigger calcium-dependent signaling cascades and the release of chemical neurotransmitters. Based on their central importance as concierges of excitation-secretion coupling and therefore neuronal communication, VGCCs have been studied in multiple aspects of neuronal function and malfunction. However, studies on molecular interaction partners …
Infecciones de transmisión sexual en población joven ¿qué mantiene su exposición al riesgo?
2019
Las infecciones de transmisión sexual, suponen uno de los riesgos más prevalentes entre lapoblación joven. En España, su incidencia se ha incrementado en los últimos años, siendo uno los países más afectados de Europa. Si bien se han llevado a cabo distintos esfuerzos preventivos para revertir la situación, no han mostrado la eficacia esperada. Por eso, resulta necesario profundizar en el análisis de aquellos factores que podrían mantener las conductas de riesgo. Así pues, el objetivo del presente estudio es evaluar el papel de factores psicológicos en la prevención de infecciones de transmisión sexual entre población joven. Para ello, 984 jóvenes de entre 18 y 24 años (32,7% hombres y 67,3…
The cholinergic system in Down's syndrome
2006
The cholinergic system is one of the most important modulatory neurotransmitter systems in the brain. Alterations of the transmission communicators are accompanied by reduction of the cortical activity, which is associated with a learning and memory deficit. Down's syndrome is a pathological condition characterized by a high number of abnormalities that involve the brain.The cholinergic system is involved in alterations of the neurological system such as severe learning difficulties.To explain these alterations, important results are obtained from studies about murine trisomy 16 (animal model of Down's syndrome).The results obtained provide useful elements in the improvement of knowledge ab…
Informal, formal institutions and credit: complements or substitutes?
2019
AbstractThis paper analyses the relationship between informal institutions measured by social trust and the provision of private credit. Research on the trust–finance relationship abounds, although most of it is confined to the micro-level, with far fewer contributions from a wide, cross-country perspective. Considering a sample of 119 economies in the period 1993–2015, results suggest that social trust is an important determinant of private credit, and that its effects are transmitted indirectly via some particular aspects of the quality of economic-judicial institutions. In addition, and contrary to previous findings in related areas, substitutive effects for informal and formal instituti…
Analysing the effects of power swing on wind farms using instantaneous impedances
2020
Abstract Most of the grid disturbances happen due to the presence of faults and power swing. This article focuses on power swing in view of the amount of penetration of renewable energy resources especially the wind farms. There are two sections. First section approached power swing by deriving a mathematical expression which would be able to track the locus of impedance in time domain and subsequently analyze resistance and reactance simultaneously with respect to time. It used a grid comprising of generator, transmission line and load. The derived expression was compared with a power swing generated using RTDS model and the results were analyzed in R-X plane. Second section analyses the i…