Search results for "SN"
showing 10 items of 3585 documents
MindBEAGLE — A new system for the assessment and communication with patients with disorders of consciousness and complete locked-in syndrom
2017
Patients with disorders of consciousness (DOC) cannot reply to questions or clinical assessments using voluntary motor control, and therefore it is very difficult to assess their cognitive capabilities and conscious awareness. Patients who are locked-in (LIS) are instead fully conscious, and they can communicate with their preserved eye movements. However, when the residual oculomotor activity is also lost (e.g., patients with amyotrophic lateral sclerosis disease of very long duration), the locked-in status becomes complete (CLIS). In CLIS patients, detection of conscious awareness may become very challenging, similarly to the subjects with DOC. mindBEAGLE has a physiological testing batte…
Functional Nasal Surgery and Use of CPAP in OSAS Patients: Our Experience.
2018
The surgical correction of nasal obstruction is definitely effective and recommended in patients with poor CPAP compliance, often secondary to the high pressures that need to be given in patients with nasal sub stenosis. For this reason, the objective of this study is the evaluation of the effectiveness and effects of the functional nose surgery on adherence to CPAP- therapy in patients (with moderate to severe OSAS with indication of ventilation therapy) poorly compliant with CPAP. The study was performed on a sample of 52 patients, 40 male and 12 female, aged between 29 and 72 years followed by the Otolaryngology Unit of the University Palermo in the period between January 2015 and Januar…
Combined Behavioral and Mismatch Negativity Evidence for the Effects of Long-Lasting High-Definition tDCS in Disorders of Consciousness: A Pilot Study
2020
Objective: To evaluate the effects of long-term High-definition transcranial direct current stimulation (HD-tDCS) over precuneus on the level of consciousness (LOC) and the relationship between Mismatch negativity (MMN) and the LOC over the therapy period in patients with Disorders of consciousness (DOCs). Methods: We employed a with-in group repeated measures design with an anode HD-tDCS protocol (2 mA, 20 min, the precuneus) on 11 (2 vegetative state and nine minimally conscious state) patients with DOCs. MMN and Coma Recovery Scale-Revised (CRS-R) scores were measured at four time points: before the treatment of HD-tDCS (T0), after a single session of HD-tDCS (T1), after the treatment of…
Event-related potentials to unattended changes in facial expressions: detection of regularity violations or encoding of emotions?
2013
Visual mismatch negativity (vMMN), a component in event-related potentials (ERPs), can be elicited when rarely presented “deviant” facial expressions violate regularity formed by repeated “standard” faces. vMMN is observed as differential ERPs elicited between the deviant and standard faces. It is not clear, however, whether differential ERPs to rare emotional faces interspersed with repeated neutral ones reflect true vMMN (i.e., detection of regularity violation) or merely encoding of the emotional content in the faces. Furthermore, a face-sensitive N170 response, which reflects structural encoding of facial features, can be modulated by emotional expressions. Owing to its similar latency …
Motor imagery and cortico-spinal excitability: A review
2016
International audience; Motor imagery (MI) has received a lot of interest during the last decades as its chronic or acute use has demonstrated several effects on improving sport performances or skills. The development of neuroimagery techniques also helped further our understanding of the neural correlates underlying MI. While some authors showed that MI, motor execution and action observation activated similar motor cortical regions, transcranial magnetic stimulation (TMS) studies brought great insights on the role of the primary motor cortex and on the activation of the cortico-spinal pathway during MI. After defining MI and describing the TMS technique, a short report of MI activities on…
A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstituti…
1994
Specific proteolysis by the tetanus toxin light chain of a vesicle-associated membrane protein (VAMP) involved in exocytosis is thought to underlie its intracellular blockade of neurotransmitter release. To substantiate this mechanism, recombinant light chain was expressed as a maltose binding protein-light chain fusion product in Escherichia coli. After purification of affinity chromatography and cleavage with factor Xa, the resultant light chain was isolated and its identity confirmed by Western blotting and N-terminal sequencing. It exhibited activity similar to that of the native light chain in proteolyzing its target in isolated bovine small synaptic vesicles and in hydrolyzing a 62-re…
Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis
2006
The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-beta1 and IL-10 polymorphisms in atherosclerosis.
On the Ultrastructure and Function of Rhogocytes from the Pond Snail Lymnaea stagnalis
2015
Rhogocytes, also termed “pore cells”, occur as solitary or clustered cells in the connective tissue of gastropod molluscs. Rhogocytes possess an enveloping lamina of extracellular matrix and enigmatic extracellular lacunae bridged by cytoplasmic bars that form 20 nm diaphragmatic slits likely to act as a molecular sieve. Recent papers highlight the embryogenesis and ultrastructure of these cells, and their role in heavy metal detoxification. Rhogocytes are the site of hemocyanin or hemoglobin biosynthesis in gastropods. Based on electron microscopy, we recently proposed a possible pathway of hemoglobin exocytosis through the slit apparatus, and provided molecular evidence of a common phylog…
Latvijas mediju ietekme uz tiesnešu neatkarību un objektivitāti
2017
Tiesa ne tikai spriež tiesu, bet arī nodrošina taisnīgumu valstī. Lai to spētu izdarīt, ir nepieciešams, lai tiktu nodrošināta tiesnešu neatkarība un objektivitāte. Objektivitāti garantē tiesnesis personīgi. Neatkarību nodrošina valsts. Ir būtiski, lai to nekas nespētu ietekmēt, ļaujot tiesnešiem taisīt taisnīgus tiesas spriedumus. Mediju ietekme ir redzama uz neskaitāmām nozarēm, to skaitā arī uz tiesas nozari, it sevišķi tāpēc, ka medijs ir starpnieks starp tiesu un sabiedrību. Nenoregulētais mediju tiesību institūts veicina nepareizu mediju lomu Latvijā. No tā visvairāk cieš ietekmētās nozares un it īpaši sabiedrība, kurai līdz ar to netiek pilnībā garantētas tiesības uz informāciju un t…
Tiesnešu pienākums respektēt nevainīguma prezumpciju krimināllietas iztiesāšanā un saziņā ar masu medijiem
2021
Nevainīguma prezumpcija ieguvusi neaizvietojamu lomu kriminālprocesa norisē kā fundamentāls kriminālprocesa pamatprincips un daļa no pamattiesībām uz taisnīgu tiesu. Nevainīguma prezumpcija paredz pieņēmumu, ka persona nav vainīga noziedzīgā nodarījuma izdarīšanā, pirms tās vaina nav pierādīta likumā noteiktajā kārtībā. Neskatoties uz to, ka tiesnešiem ir pienākums respektēt nevainīguma prezumpciju, novērojamas situācijas, kad tiesneši savos izteikumos medijiem pārkāpuši nevainīguma prezumpcijas būtību. Darbā analizēti tiesnešu izteikumi, kas pārkāpj nevainīguma prezumpciju kopsakarā ar nacionālo normatīvo regulējumu, Eiropas Savienības prasībām un attiecīgi salīdzinātas lietas, kurām tiek …