Search results for "SPAST"

Ischemia in patients with no obstructive coronary artery disease: classification, diagnosis and treatment of coronary microvascular dysfunction

2020

Patients with coronary microvascular dysfunction represent a widespread population, and despite the good prognosis, many of them, because of the angina symptoms, have a poor quality of life with strong limitations in their daily activities. In 2017, a new classification of microvascular dysfunction as well as a new definition of ischemia in patients with no obstructive coronary artery disease became available. This new definition improves Kemp's initial work, where cardiac X syndrome was initially described. This work summarizes the last updates on the subject with particular attention to the new classification of microvascular dysfunction, with particular attention to microvascular and vas…

2021

Abstract Background Individuals with cerebral palsy (CP) have problems in everyday tasks such as walking and climbing stairs due to a combination of neuromuscular impairments such as spasticity, muscle weakness, reduced joint flexibility and poor coordination. Development of evidence-based interventions are in pivotal role in the development of better targeted rehabilitation of CP, and thus in maintaining their motor function and wellbeing. Our aim is to investigate the efficacy of an individually tailored, multifaceted exercise intervention (EXECP) in children and young adults with CP. EXECP is composed of strength, flexibility and gait training. Furthermore, this study aims to verify the …

<p>Shock Waves as a Treatment Modality for Spasticity Reduction and Recovery Improvement in Post-Stroke Adults – Current Evidence and Qualitati…

2020

Purpose: This systematic review examines intervention studies using extracorporeal shock wave therapy (ESWT) application in post-stroke muscle spasticity with particular emphasis on the comparison of two different types of radial (rESWT) and focused shock waves (fESWT). Methods: PubMed, PEDro, Scopus, and EBSCOhost databases were systematically searched. Studies published between the years 2000 and 2019 in the impact factor journals and available in the English full-text version were eligible for inclusion. All qualified articles were classified in terms of their scientific reliability and methodological quality using the PEDro criteria. The PRISMA guidelines were followed and the registrat…

Amplicon-based high-throughput pooled sequencing identifies mutations in CYP7B1 and SPG7 in sporadic spastic paraplegia patients

2011

Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder defined clinically by progressive lower limb spasticity and weakness. HSP is a genetically highly heterogeneous condition with at least 46 gene loci identified so far, involving X-linked, autosomal recessive (AR) and autosomal dominant inheritance. For correct diagnosis, molecular testing is essential because clinical parameters by themselves are not reliable to differentiate HSP forms. The purpose of this study was to establish amplicon-based high-throughput genotyping for AR-HSP. A sample of 187 index cases with apparently sporadic or recessive spastic paraplegia were analyzed by applying an array-based amplification stra…

Zewnątrzustrojowa Fala Uderzeniowa (ESW) jako alternatywna metoda wspomagająca terapię porażenia spastycznego mięśni kończyn w wyniku udaru mózgu - p…

2017

Zewnątrzustrojowa fala uderzeniowa (ESW – Extracorporeal Shock Wave) jest czynnikiem fizykalnym, którego zastosowanie kliniczne obserwowane jest w szerokiej gamie zaburzeń chorobowych, szczególnie dysfunkcji narządu ruchu. Obecnie zaobserwować można, iż lista wskazań do zabiegów ESW stale rośnie i obejmuje swym zasięgiem coraz to bardziej odmienne pod względem etiologii i patomechanizmu schorzenia ogólnoustrojowe. Niemniej jednak pamiętać należy, iż potencjalne mechanizmy biologiczne stymulacji ESW, warunkujące korzystne i pożądane efekty terapeutyczne, nie są jednoznacznie wyjaśnione. W świecie nauki w dalszym ciągu obserwowany jest brak niepodważalnych dowodów popartych zaawansowanymi bad…

Multilevel functional surgery in adults with acquired spasticity of upper extremity

2004

The authors present their expertise in the treatment of acquired spasticity of the upper extremity in adults, illustrating the basics of modern functional surgery, which benefits from the achievements in bioengineering and information technology and new surgical techniques. Moreover close cooperation between the physical therapist and surgeon is essential in planning a new treatment scheme which, when possible, may successfully strengthen and optimize the function control of the remaining extremity, thus overriding the old concept of merely correcting the deformity. Results depend on proper scrutiny of the preoperative clinical and instrumental details on successful surgical accomplishment …

The Effects of Transcutaneous Spinal Direct Current Stimulation on Neuropathic Pain in Multiple Sclerosis: Clinical and Neurophysiological Assessment

2019

Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality of life. Spinal mechanisms may contribute to the pathogenesis of neuropathic pain in MS. Converging evidence from animal models and neurophysiological and clinical studies in humans suggests a potential effect of transcranial direct current stimulation (tc-DCS) on neuropathic pain. Spinal application of DCS, i.e., transcutaneous spinal DCS (ts-DCS), may modulate nociception through inhibition of spinal reflexes. Therefore, ts-DCS could represents an effective, safe and well-tolerated treatment for neuropathic pain in MS, a largely unexplored topic. This…