Search results for "SPIO"

Market must be defended: The role of counter-espionage policy in protecting domestic market welfare

2022

Governments of advanced economies are extremely concerned about the illicit acquisition of information on critical technologies employed by their industries, and countering this economic espionage is quickly becoming one of their top priorities. The present paper advances the theoretical analysis of the interaction between economic espionage and counter-espionage, and presents a first approximation to an inquiry into the rationale for the influence of market competition in its dynamics. The proposed model assumes a country with a one-market economy open to international trade whose product is supplied by domestic firms. Moreover, successful economic espionage implying market entry of foreig…

Cuando secretos de Estado y espionaje chocan contra los derechos fundamentales

2022

Caso sobre el uso del programa espía Pegasus. Control servicios de inteligencia. Derechos fundamentales y secreto de Estado

Contra el espionaje ¡Milicianos! No deis detalles sobre la situación de los frentes Ni a los camaradas Ni a los hermanos Ni a las novias.

Al capdavall "Ación (sic) Obreros litógrafos" En l'angle superior dret una cara amb una gran orella en actitud d'escoltar. En l'inferior esquerre, altra cara amb el dit índex en els llavis indicant silenci

Espías sin fronteras

2000

Functionnalized magnetite nanoparticles for bimodal imaging MRI/PET

2015

Functionalized magnetite nanoparticles for bimodal MRI/PET imagingSuperParamagnetic Iron Oxide Nanoparticles (SPIONs) have been widely studied in the biomedical field due to their promising application as nanodrugs and MRI (Magnetic Resonance Imaging) contrast agents (T2). In this study, magnetite (Fe3O4) nanoparticles have been developed for use as contrast agents for MRI/PET (Positron emission tomography) double imaging. First, functionalized stable superparamagnetic SPIONs have been synthesized in a continuous hydrothermal reactor. During the synthesis, hydrophilic agents (citric acid, LDOPA, DHCA and PHA) have been grafted on the surface of the nanoparticles. The functionalization of th…

Guerre, espionnage, torture. A propos d'une entreprise contre Dijon en 1432

2016

International audience

Inulin-based polymer coated SPIONs as potential drug delivery systems for targeted cancer therapy

2014

This paper deal with the synthesis and characterization of PEGylated squalene-grafted-inulin amphiphile capable of self-assembling and self-organizing into nanocarriers once placed in aqueous media. It was exploited as coating agent for obtaining doxorubicin loaded superparamagnetic iron oxide nanoparticles (SPIONs) endowed with stealth like behavior and excellent physicochemical stability. Inulin was firstly modified in the side chain with primary amine groups, followed in turn by conjugation with squalenoyl derivatives through common amidic coupling agents and PEGylation by imine linkage. Polymer coated SPIONs were so obtained by spontaneous self-assembling of inulin copolymer onto magnet…

Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance.

2020

Journal of nanobiotechnology 18, 22 (2020). doi:10.1186/s12951-020-0580-1

Synthesis and study of new fluorescent probes for optical imaging, Cherenkov imaging and multimodal imaging

2015

The goal of this work was to prepare and study new fluorescent probes, which could give rise to novel optical or Cherenkov imaging agents. The first section of this work describes the synthesis of fluorescent subphthalocyanines and phthalocyanines probes, which possess relevant chemicals groups suitable for optical imaging applications. The optical and physico-chemical properties of the new probes were carefully examined to ensure they comply with the specification of the fluorophores for the desired application. The second part focused on the subsequent development of a few selected probes into real imaging agents. The biovectorisation of subphtalocyanines was achieved upon conjugation of …

Smart copolymer coated SPIONs for colon cancer chemotherapy

2019

Human colon cancer is one of the higher aggressive solid tumors, whose high mortality, much like many other solid tumors, results from metastasis formation. To reduce this high mortality, more effective chemotherapy, allowing a specific tumor accumulation and an efficient early-stage medical imaging as well, are still needed. At this regard, stimuli-responsive nanocarriers for anticancer drug delivery are promising strategy in cancer therapy. For this purpose, a dual targeted redox-responsive drug delivery system, prepared by coating superparamagnetic nanoparticles (SPIONs) with the amphiphilic copolymer INU-LA-PEG-FA and loading doxorubicin (DOXO-SPIONs) was investigated as tool for solid …