Search results for "STING"

High efficiency and clinical relevance of exome sequencing in the daily practice of neurogenetics

2021

ObjectiveTo assess the efficiency and relevance of clinical exome sequencing (cES) as a first-tier or second-tier test for the diagnosis of progressive neurological disorders in the daily practice of Neurology and Genetic Departments.MethodsSixty-seven probands with various progressive neurological disorders (cerebellar ataxias, neuromuscular disorders, spastic paraplegias, movement disorders and individuals with complex phenotypes labelled ‘other’) were recruited over a 4-year period regardless of their age, gender, familial history and clinical framework. Individuals could have had prior genetic tests as long as it was not cES. cES was performed in a proband-only (60/67) or trio (7/67) st…

Models of e-testing

2017

Transdisciplinary interest and preoccupations regarding computer-assisted instruction have stirred our urge to perform a thorough study of the field and trends as well as to uphold certain approaches that have emerged in specialized scientific research. We have decided to focus our analysis primarily on the assessment process as a part of computer-assisted instruction; this in fact represents the major objective of our research, whereas the results of the experiments, performed in the context of the research projects undertaken, enabled us to set forth relevant conclusions about e-testing. Our computer-assisted assessment primarily includes tests with objective or semi-objective items, whic…

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

2019

The availability of in vitro tools that are constructed on the basis of a detailed knowledge of key aspects of gastrointestinal (GI) physiology and their impact on formulation performance and subsequent drug release behaviour is fundamental to the success and efficiency of oral drug product development. Over the last six years, the development and optimization of improved, biorelevant in vitro tools has been a cornerstone of the IMI OrBiTo (Oral Biopharmaceutics Tools) project. By bringing together key industry and academic partners, and by linking tool development and optimization to human studies to understand behaviour at the formulation/GI tract interface, the collaboration has enabled …

Cost Management for IT Activities: A Case Study in the IT Division of a French Bank Using Activity-Based Costing

2013

The costs of information technology (IT) activities have been increasing rapidly these recent years, due to the technological sophistication and more market-oriented strategies that complexify the value chains of the firms. Many of these expenses do not relate to individual products but are associated to customers, market segments and distribution channels. In this context, the companies try to understand the cost of selling their products and services. This is the reason why customer-driven and market-oriented cost management approaches have gained in popularity.In this paper, we review in a first part the strategic cost management stream and the way we can give a customer orientation to c…

A measurement scale for product innovation performance

2006

PurposeThe purpose of this paper is to report the results of a study aimed at conceptualising and developing valid measurements for two key dimensions of product innovation performance‐efficacy and efficiency – in the context of firm competition.Design/methodology/approachData were collected from French biotechnology firms. Using structural equations modeling, the constructs’ measurement models were tested and the scale was validated.FindingsThe results of the study indicate that the operational measures developed here satisfy the criteria for unidimensionality, reliability, and validity.Research limitations/implicationsThis study contributes to innovation management research by providing a…

Method for Estimating the Manual Nesting Process Efficiency for Profiling Machines, Based upon Image Processing Techniques

2015

The paper presents a method for estimating the efficiency of the manual nesting process. By using the graphic file generated during the nesting process and using image processing techniques, the method allows the user to calculate the percentage of material used for manufacturing the parts. The method combines a manual approach - the user has to select some specific points on the graphic file with the mouse, with some image processing algorithms form Matlab software package.

Programmatūras testēšana un trasējamība

2005

Cytotoxicity and induction of DNA double-strand breaks by components leached from dental composites in primary human gingival fibroblasts

2012

Abstract Introduction The public interest steadily increases in the biological adverse effects caused by components released from resin-based dental restorations. Objective In this study, the cytotoxicity and the genotoxicity were investigated of following released components from dental resin restorations in human gingival fibroblasts (HGF): tetraethyleneglycol dimethacrylate (TEEGDMA), neopentylglycol dimethacrylate (Neopen), diphenyliodoniumchloride (DPIC), triphenyl-stibane (TPSB) and triphenylphosphane (TPP). Methods XTT based cell viability assay was used for cytotoxicity screening of substances. γ-H2AX assay was used for genotoxicity screening. In the γ-H2AX assay, HGFs were exposed …

Optogenetically Controlled Activity Pattern Determines Survival Rate of Developing Neocortical Neurons

2021

A substantial proportion of neurons undergoes programmed cell death (apoptosis) during early development. This process is attenuated by increased levels of neuronal activity and enhanced by suppression of activity. To uncover whether the mere level of activity or also the temporal structure of electrical activity affects neuronal death rates, we optogenetically controlled spontaneous activity of synaptically-isolated neurons in developing cortical cultures. Our results demonstrate that action potential firing of primary cortical neurons promotes neuronal survival throughout development. Chronic patterned optogenetic stimulation allowed to effectively modulate the firing pattern of single ne…

Quantum Algorithm for Distribution-Free Junta Testing

2019

Inspired by a recent classical distribution-free junta tester by Chen, Liu, Serverdio, Sheng, and Xie (STOC’18), we construct a quantum tester for the same problem with complexity \(O(k/\varepsilon )\), which constitutes a quadratic improvement.