Search results for "STING"

Feasibility of shotgun urinary proteomics for investigating prematurely born preschoolers (PBP)

2016

Background: Preterms and twins are at higher risk of respiratory morbidity later in life. Advances in proteomic approaches may allow the characterization of biomarkers involved in respiratory diseases (Mauri et al. Imm. Lett. 2014;162:2-10). Gel-free approach quantitatively identify differentially expressed proteins in relation to physiopathological conditions (Mauri&Dehò, Meth Enzymology 2008;447:99-117). This can improve the clinical reliability of the next generation of biomarkers to discriminate multiple phenotypes of childhood respiratory diseases. Aim: To assess the ability of gel-free proteomics for identifying specific protein profiles related to PBP. Methods: Urine samples were…

Real-time detection of BRAF V600E mutation from archival hairy cell leukemia FFPE tissue by nanopore sequencing

2018

The MinION is a miniaturized high-throughput next generation sequencing platform of novel conception. The use of nucleic acids derived from formalin-fixed paraffin-embedded samples is highly desirable, but their adoption for molecular assays is hurdled by the high degree of fragmentation and by the chemical-induced mutations stemming from the fixation protocols. In order to investigate the suitability of MinION sequencing on formalin-fixed paraffin-embedded samples, the presence and frequency of BRAF c.1799T > A mutation was investigated in two archival tissue specimens of Hairy cell leukemia and Hairy cell leukemia Variant. Despite the poor quality of the starting DNA, BRAF mutation was su…

Automated anaesthesia record systems, observations on future trends of development.

1995

The introduction of electronic anaesthesia documentation systems was attempted as early as in 1979, although their efficient application has become reality only in the past few years. Today, documentation technology is offered by most of the monitor manufacturers and new systems are being developed by various working groups. The advantages of the electronic protocol are apparent: Continuous high quality documentation, comparability of data due to the availability of a anaesthesia data bank, reduction of the workload of the anaesthesia staff and availability of new additional information. Disadvantages of the electronic protocol have also been discussed. Typically, by going through the proce…

Familiarization process in cardiorespiratory fitness testing for persons with mental retardation

1995

The purpose of this article is to review the familiarization protocols and other factors used in laboratory and field testing studies implemented to measure the cardiorespiratory fitness of persons with mental retardation. Test selection issues, pretest familiarization procedures, and motivational strategies will be discussed. Little information is available to identify specific guidelines for familiarizing a subject with a specific protocol prior to cardiorespiratory fitness testing. The recommendations suggested in this article provide valuable and necessary information for researchers interested in the measurement of cardiorespiratory fitness of persons with mental retardation.

200 TEST/RETEST- AND INTEROBSERVER-RELIABILITIY IN QUANTITATIVE SENSORY TESTING ACCORDING TO THE PROTOCOL OF THE GERMAN NETWORK ON NEUROPATHIC PAIN (…

2007

Dynamic Test Methods for COTS SRAMs

2014

International audience; In previous works, we have demonstrated the importance of dynamic mode testing of SRAM components under ionizing radiation. Several types of failures are difficult to expose when the device is tested under static (retention) mode. With the purpose of exploring and defining the most complete testing procedures and reveal the potential hazardous behaviors of SRAM devices, we present novel methods for the dynamic mode radiation testing of SRAMs. The proposed methods are based on different word address accessing schemes and data background: Fast Row, Fast Column, Pseudorandom, Adjacent (Gray) and Inverse Adjacent (Gray). These methods are evaluated by heavy ion and atmos…

P-Value, Confidence Intervals, and Statistical Inference: A New Dataset of Misinterpretation

2017

Statistical inference is essential for science since the twentieth century (Salsburg, 2001). Since it's introduction into science, the null hypothesis significance testing (NHST), in which the P-value serves as the index of “statistically significant,” is the most widely used statistical method in psychology (Sterling et al., 1995; Cumming et al., 2007), as well as other fields (Wasserstein and Lazar, 2016). However, surveys consistently showed that researchers in psychology may not able to interpret P-value and related statistical procedures correctly (Oakes, 1986; Haller and Krauss, 2002; Hoekstra et al., 2014; Badenes-Ribera et al., 2016). Even worse, these misinterpretations of P-value …

Commentary: Psychological Science's Aversion to the Null

2017

The Agony of Choice: Acceptance, Efficiency, and Psychometric Properties of Questionnaires With Different Numbers of Response Options

2021

Questionnaires are one of the most important tools in psychological assessment, yet the impact of different numbers of response options on psychometric properties of questionnaires is limited. This study extends existing research by analyzing respondents’ acceptance of and the efficiency of different numbers of response options and replicate findings on reliability and validity. We studied these questions in 540 respondents who filled out the Big Five Inventory–2 and the Emotion Regulation Questionnaire. Two response options, 11 response options and the visual analog scale showed disadvantages in acceptance compared with the original number of response options. The completion time increase…

Work-home interaction from a work psychological perspective: Development and validation of a new questionnaire, the SWING

2005

Contains fulltext : 54536.pdf (Publisher’s version ) (Closed access) This paper reports on the stepwise development of a new questionnaire for measuring work-home interaction, i.e. the Survey Work-home Interaction—NijmeGen, the SWING). Inspired by insights from work psychology, more specifically from Effort-Recovery Theory (Meijman & Mulder, 1998), we defined work-home interaction by differentiating between the direction and quality of influence. Four types of work-home interaction were distinguished and measured by using 22 (including 13 self-developed) items. By using data from five independent samples (total N=2472), validity evidence was provided based on the internal structure of the q…