Search results for "STING"

The Molecular Basis of X-Linked Spondyloepiphyseal Dysplasia Tarda

2001

The X-linked form of spondyloepiphyseal dysplasia tarda (SEDL), a radiologically distinct skeletal dysplasia affecting the vertebrae and epiphyses, is caused by mutations in the SEDL gene. To characterize the molecular basis for SEDL, we have identified the spectrum of SEDL mutations in 30 of 36 unrelated cases of X-linked SEDL ascertained from different ethnic populations. Twenty-one different disease-associated mutations now have been identified throughout the SEDL gene. These include nonsense mutations in exons 4 and 5, missense mutations in exons 4 and 6, small (2–7 bp) and large (>1 kb) deletions, insertions, and putative splicing errors, with one splicing error due to a complex deleti…

Observations on a new species of Unicapsula (Myxosporida) in the fish Maena smaris (L.) by conventional and electronmicroscopy

1975

A myxosporidian parasite believed to be congeneric with Unicapsula muscularis Davis (1924), type (and only) species of this genus, was found in the dorsal muscles of the fish Maena smaris (L.) at Banyuls-sur-Mer, France. The spores were tripartite, with corresponding components of the three parts differentially developed. One part consisted of a small shell valve overlying no more than a trace of sporoplasm but covering a polar apparatus with well-developed polar capsule. Each of the other two parts consisted of a long shell valve covering a large sporoplasm and a polar apparatus with only the rudiment of a polar capsule. Electron microscope pictures of the trophozoite showed evidence of pi…

Safety assessment of food-contact paper and board using a battery of short-term toxicity tests: European union BIOSAFEPAPER project.

2005

International audience; An European Union (EU)-funded project QLK1-CT-2001-00930 (BIOSAFEPAPER) involves the development, validation and intercalibration of a short-term battery of toxicological tests for the safety assessment of food-contact paper and board. Dissemination of the results to industry, legislators (e.g. DG Consumer Protection, DG Enterprises, DG Research), standardization bodies such as CEN, and consumers will create an agreed risk evaluation procedure. The project involves pre-normative research in order to establish a set of in-vitro cytotoxicity and genotoxicity tests that will be easily adaptable to food-contact fibre-based materials and have endpoints relevant to consume…

Self-powered IoT Device based on Energy Harvesting for Remote Applications

2018

In this paper, we present the design and prototype implementation of self-powered Internet of Things (IoT) device based on energy harvesting from a small solar panel of size 63mm x 63mm and 0.36W for remote applications. These IoT devices can be deployed in remote places within the range of a gateway. A complete proof of concept IoT device based on ambient energy harvesting is designed, prototyped and tested with super capacitors and Lithium cells in star topology. Based on the measurements, the IoT device can potentially last for one year with 55 seconds transmission interval with the fully charged 120mAh coin cell battery. On the other hand, a fully charged single 5F supercapacitor lasts …

Quinoa wet-milling: Effect of steeping conditions on starch recovery and quality

2019

Cereal starches play an important role in the food and non-food industries because of their low cost, availability, and ability to impart a wide range of techno-functional properties. The main objective of this research was to isolate starch, germ, protein, and fiber components from quinoa by a wet-milling procedure. The effect of steeping time and temperature on starch recovery and its quality was investigated. The quinoa steeping conditions, such as time (1, 5, and 9 h) and temperature (30, 40, and 50 °C), in SO2 solution with lactic acid were investigated using a 32 factorial design in order to optimize the starch separation and its quality. The effect of steeping conditions on starch wa…

Rainwater Interest in Urban Areas of E urope, the State of Art (1980–2016)

2021

Parasite infracommunities as predictors of harvest location of bogue (Boops boops L.): a pilot study using statistical classifiers

2005

The accuracy of classifying bogue (Boops boops) according to the fishery from which it was harvested was evaluated by applying several statistical classification techniques to fish parasite abundances. Bogue captured in 2001 in two fisheries off the Atlantic coast of Spain were compared with one off the Spanish Mediterranean coast. One hundred bogue were classified to each harvest location (fishery) using different numbers of parasite species chosen as predictors by a best subset method. Two parametric methods of classification (linear and quadratic discriminant analysis) were compared with two non-parametric approaches (k-nearest neighbour classification and feed-forward neural network) an…

Markov Chain Monte Carlo Methods for High Dimensional Inversion in Remote Sensing

2004

SummaryWe discuss the inversion of the gas profiles (ozone, NO3, NO2, aerosols and neutral density) in the upper atmosphere from the spectral occultation measurements. The data are produced by the ‘Global ozone monitoring of occultation of stars’ instrument on board the Envisat satellite that was launched in March 2002. The instrument measures the attenuation of light spectra at various horizontal paths from about 100 km down to 10–20 km. The new feature is that these data allow the inversion of the gas concentration height profiles. A short introduction is given to the present operational data management procedure with examples of the first real data inversion. Several solution options for…

Bayesian analysis and design for comparison of effect-sizes

2002

Comparison of effect-sizes, or more generally, of non-centrality parameters of non-central t distributions, is a common problem, especially in meta-analysis. The usual simplifying assumptions of either identical or non-related effect-sizes are often too restrictive to be appropriate. In this paper, the effect-sizes are modeled as random effects with t distributions. Bayesian hierarchical models are used both to design and analyze experiments. The main goal is to compare effect-sizes. Sample sizes are chosen so as to make accurate inferences about the difference of effect-sizes and also to convincingly solve the testing of equality of effect-sizes if such is the goal.

The size of Simes’ global test for discrete test statistics

1999

Abstract To increase the power of the Bonferroni–Holm procedure several modified Bonferroni procedures have been proposed (for example, Hochberg, 1988. Biometrika 75, 800–802; Hommel, 1988. Biometrika 75, 383–386), which are based on Simes’ global test (Simes, 1986. Biometrika 73, 751–754). By several simulation studies which, in particular, considered multinormal test statistics, it has been suggested that the Simes test is a level α test. However, an exact proof exists for only few situations one of them assuming independence of test statistics. We studied the behaviour of Simes’ test for discrete test statistics. Due to discreteness one can expect more conservative decisions whereas depe…