Search results for "STP"
showing 10 items of 236 documents
Cluster-determinant 36 (CD36) impacts on vitamin E postprandial response
2014
International audience; Scope: A single nucleotide polymorphism in the cluster determinant 36 (CD36) gene has recently been associated with plasma alpha-tocopherol concentration, suggesting a possible role of this protein in vitamin E intestinal absorption or tissue uptake. Methods and results: To investigate the involvement of CD36 in vitamin E transport, we first evaluated the effect of CD36 on alpha- and gamma-tocopherol transmembrane uptake and efflux using transfected HEK cells. gamma-Tocopherol postprandial response was then assessed in CD36-deficient mice compared with wild-type mice, after the mice had been fully characterized for their alpha -tocopherol, vitamin A and lipid plasma,…
Luminal Lipid Regulates CD36 Levels and Downstream Signaling to Stimulate Chylomicron Synthesis
2011
International audience; The membrane glycoprotein CD36 binds nanomolar concentrations of long chain fatty acids (LCFA) and is highly expressed on the luminal surface of enterocytes. CD36 deficiency reduces chylomicron production through unknown mechanisms. In this report, we provide novel insights into some of the underlying mechanisms. Our in vivo data demonstrate that CD36 gene deletion in mice does not affect LCFA uptake and subsequent esterification into triglycerides by the intestinal mucosa exposed to the micellar LCFA concentrations prevailing in the intestine. In rodents, the CD36 protein disappears early from the luminal side of intestinal villi during the postprandial period, but …
Obstetric-Neonatal Care during Birth and Postpartum in Symptomatic and Asymptomatic Women Infected with SARS-CoV-2: A Retrospective Multicenter Study
2022
Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/1660-4601/19/9/5482 Este artículo de investigación pertenece a la colección "COVID-19 Research". En este artículo de investigación también participan: Laura Andreu-Pejó, Cristina Martínez-Porcar, Carmen Rodríguez Gonzálvez, Patricia Torrent-Ramos, Nieves Asensio-Tomás, Yolanda Herraiz-Soler, Ramon Escuriet y Desirée Mena-Tudela. This study analyses the obstetric–neonatal outcomes of women in labour with symptomatic and asymptomatic COVID-19. A retrospective, multicenter, observational study was carried out between 1 March 2020 and 28 February 2021 in eight public hospitals in the Valencian community (Spain). The…
Refining sorafenib therapy: lessons from clinical practice
2015
ABSTRACT Understanding the best use of sorafenib is essential in order to maximize clinical benefit in hepatocellular carcinoma. Based on Phase III and noninterventional study data, as well as our extensive experience, we discuss dose modification in order to manage adverse events, disease response evaluation and how to maximize treatment benefit. Sorafenib should be initiated at the approved dose (400 mg twice daily) and reduced/interrupted as appropriate in order to manage adverse events. Dose modification should be considered before discontinuation. Appropriate tumor response assessment is critical. Focusing on radiologic response may result in premature sorafenib discontinuation; symp…
Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum women.
2009
The post-partum period is a time of extreme vulnerability for a whole spectrum of psychiatric disorders. Delivery may be considered an important risk factor in genetically susceptible women. Five hundred and eight SNPs in 44 genes at candidate pathways putatively related to mood changes after delivery were genotyped in a multicenter cohort of 1804 women from Spain. Participants completed two scales at 2-3 days, 8 weeks, and 32 weeks post-partum, the Edinburgh Post-partum Depression Scale (EPDS) and the Spielberger State-Trait Anxiety Inventory (STAI). Those women who scored 9 or more on EPDS were evaluated for major depression using the Diagnostic Interview for Genetics Studies (DIGS) adapt…
Intramuscular tranexamic acid
2021
For many anaesthetists around the world, the mere mention of the word ‘pharmacokinetics’ is sufficient to make their eyes glaze over and their attention wander. Pharmacokinetics is seen as an art that is as obscure and esoteric as the art of divination (prediction) practiced by the likes of Professor Sybille Trelawny 1 but that has varying and mostly limited relevance to clinical practice. Although this hyperbole may have elements of truth, it is a fact that pharmacokinetic data are the essential foundation upon which rational drug dosing guidelines are developed for all drugs.
Somnolencia y fatiga materna en los primeros años de crianza y ejecución en la conducción evaluada en simulador
2017
RESUMEN DE LA TESIS DOCTORAL Somnolencia y fatiga materna en los primeros años de crianza y ejecución en la conducción evaluada en simulador El nacimiento de un bebé y la crianza posterior durante la primera infancia supone un considerable esfuerzo para madres y padres, que provoca cambios profundos en la familia, tanto si se trata del primer hijo/a como de la incorporación de un nuevo miembro más a la familia. Un bebé recién nacido necesita atención constante por parte de sus cuidadores, y los padres deben responder a las intensas demandas de cuidado que requiere, sobre todo porque el bebé no tiene un ritmo circadiano establecido, su sueño se distribuye a lo largo del día y de la noche en …
Comparative morphology of the postpharyngeal gland in the Philanthinae (Hymenoptera, Crabronidae) and the evolution of an antimicrobial brood protect…
2015
Background Hymenoptera that mass-provision their offspring have evolved elaborate antimicrobial strategies to ward off fungal infestation of the highly nutritive larval food. Females of the Afro-European Philanthus triangulum and the South American Trachypus elongatus (Crabronidae, Philanthinae) embalm their prey, paralyzed bees, with a secretion from a complex postpharyngeal gland (PPG). This coating consists of mainly unsaturated hydrocarbons and reduces water accumulation on the prey’s surface, thus rendering it unfavorable for fungal growth. Here we (1) investigated whether a North American Philanthus species also employs prey embalming and (2) assessed the occurrence and morphology of …
Ar superformulu ģenerētu objektu īpašības un pielietojumi
2019
Bakalaura darba mērķis ir izpētīt ierobežojumus, kādi attiecas uz figūrām, kuras ģenerētas, izmantojot superformulu, kā arī pētīt praktiskus pielietojumus šādam figūru ģenerēšanas paņēmienam. Dabā sastopamu formu ģenerēšanai bieži vien nepieciešami netriviāli vienādojumi vai pārveidojumi, kas patērē gan laika, gan atmiņas resursus. Izmantojot superformulu, šādu formu ģenerēšanai nepieciešami tikai daži parametri. Tā kā visas šādi ģenerētas figūras apraksta viena formula, tad ir iespējams izmantot analītiskas metodes, lai noteiktu figūru un taišņu krustpunktus, kā arī attālumus starp šādi veidotām figūrām. Darbā vispirms tiek apskatītas superelipšu un superformulas īpašības, pēc tam tiek aps…
Baltijas valstu pensiju sistēmu veidošanās un to pilnveidošanās analīze
2015
Maģistra darba tēma ir „Baltijas valstu pensiju sistēmu veidošanās un to pilnveidošanās analīze”. Demogrāfisko pārmaiņu radītās problēmas arvien ir centrālais punkts debatēm ne tikai Baltijas valstīs, bet arī visā Eiropas Savienībā kopumā. Iedzīvotāju straujā novecošanās, jo īpaši kopā ar darbaspēka samazināšanos, rada bažas gan par pensiju sistēmu ilgtspēju, gan par nākotnes ekonomisko izaugsmi. Līdz ar to viens no aktuālākaiem jautājumiem Baltijas valstīs ir, kā nodrošināt ilgtspējīgu sociālās aizsardzības shēmu, nepalielinot demogrāfisko un nodokļu slogu uz nākamajām paaudzēm nākotnē. Darba mērķis ir, pamatojoties uz Baltijas valstu pensiju sistēmu izpēti, kā arī makroekonomisko un demog…