Search results for "STRESS"
showing 10 items of 6278 documents
LE EMOZIONI NELLE ORGANIZZAZIONI: POSSIAMO DAVVERO IGNORARLE?
2014
Introduzione. Questo studio esplora l'importanza delle esperienze affettive dei lavoratori nel settore dei servizi, partendo dall’ipotesi di ricerca: come possono le esperienze affettive sul luogo di lavoro contribuire a spiegare gli esiti dello stress lavorativo? L’Affective Events Theory (AET) costituisce il fondamento teorico di partenza. Obiettivi e Metodi. In particolare, l’obiettivo principale del presente studio è stato quello di indagare il ruolo che gli stati affetti positivi e negativi sperimentati sul luogo di lavoro giocano come mediatori della relazione tra le caratteristiche del lavoro e gli esiti del processo dello stress lavorativo. A partire dal modello JD-R, è stato testat…
Il benessere aziendale percepito: tra senso di appartenenza e soddisfazione lavorativa
2013
Il presente contributo analizza alcune variabili ritenute dalla letteratura sull’argomento componenti fondamentali del benessere aziendale: l’orientamento al team, il senso di appartenenza aziendale, il senso di efficacia organizzativa, l’identificazione con l’azienda e la soddisfazione lavorativa. I partecipanti alla ricerca sono 58 dirigenti di aziende siciliane. I dati mostrano come il senso di appartenenza all’azienda sia centrale, essendo l’unica variabile tra quelle indagate che influisce sulla soddisfazione lavorativa. Inoltre, il senso di efficacia organizzativa, ossia il percepire che la propria azienda e in grado di affrontare le difficolta e di raggiungere i risultati attesi e fo…
Study of leurocyte telomere lenght and transcription in patients in the acute phase of myocardial infarction
2011
Atherosclerosis with cardiovascular complications remains today one of the leading causes of death in developed countries. In this context, development of new biomarkers of atherosclerosis has an important place. Objectives of these biomarkers are: • to identify populations most at risk of developing cardiovascular complications, • to stratify patient groups to optimize their clinical management and therapeutic, • to reveal new therapeutic targets in the treatment of the disease. In this context, we identified three biomarkers of interest, leukocyte telomere length (LTL) and level of expression of leukocyte genes c-Fos (involved in inflammatory processes and oxidative) and OGG1 (necessary r…
Innovative strategies to treat skin wounds with mangiferin: fabrication of transferosomes modified with glycols and mucin
2020
Aim: The moisturizing properties of glycerol, the penetration enhancing capability of propylene glycol and the bioadhesive properties of mucin were combined to improve the carrier capabilities of transfersomes and the efficacy of mangiferin in the treatment of skin lesions. Materials & methods: Mangiferin was incorporated in transfersomes and glycoltransfersomes, which were also modified with mucin. The physico–chemical features were assessed, along with the efficacy against oxidative stress and skin wounds in vitro and in vivo. Results: Glycoltransfersomes promoted the deposition of mangiferin in epidermis and dermis, protected fibroblasts from oxidative stress and stimulated their pr…
High-content analysis of oxygen reactive species and oxidative stress for toxicology in vitro
2010
Tributyltin affects phagocytic activity of Ciona intestinalis hemocytes
1995
Organotin compounds have been used in marine anti-fouling paints as biocides. Because tunicates are vulnerable to these compounds in their natural habitats, we used Ciona intestinalis to establish an assay for phagocytosis in vitro of yeast by hemocytes after exposure to different concentrations (0.0015, 0.015, 0.15 and 1.5 microM) of four organotin compounds: tributyltin (TBT), triphenyltin (TPT), dibutyltin (DBT) and diphenyltin (DPT). To evaluate the phagocytic activity, we used a method based on fluorescence excitation of yeast pre-treated with eosin-Y. The percentage of phagocytosis decreased from 45.1 +/- 3.49 to 22.4 +/- 5.14 at 1.5 microM of TBT (P0.001); it was significantly reduce…
Effects in cigarette smoke stimulated bronchial epithelial cells of a corticosteroid entrapped into nanostructured lipid carriers
2014
Background Nanomedicine studies have showed a great potential for drug delivery into the lung. In this manuscript nanostructured lipid carriers (NLC) containing Fluticasone propionate (FP) were prepared and their biocompatibility and effects in a human bronchial epithelial cell line (16-HBE) stimulated with cigarette smoke extracts (CSE) were tested. Results Biocompatibility studies showed that the NLC did not induce cell necrosis or apoptosis. Moreover, it was confirmed that CSE increased intracellular ROS production and TLR4 expression in bronchial epithelial cells and that FP-loaded NLC were more effective than free drug in modulating these processes. Finally, the nanoparticles increased…
Biocompatibility, hemocompatibility and antimicrobial properties of xyloglucan-based hydrogel film for wound healing application.
2018
Crosslinked xyloglucan-poly(vinyl alcohol) based hydrogel films are interesting materials for wound healing applications. This work focuses on the hydrolytic degradation and consequent morphological modification of a XG-PVA film and on its interaction with cells, blood, bacteria. Biocompatibility of the film was assessed in vitro by investigating different aspects, such as cell viability, oxidative stress level, mitochondrial dysfunction and specific stress biomarkers. Partial adhesiveness was demonstrated by performing different attaching assays and phalloidin staining. Hemocompatibility of XG-PVA film after interaction with blood was evaluated by using a multi-parametric approach, includi…
The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS
2021
Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of the motor system. It is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and paralysis. ALS is incurable and has a bleak prognosis, with median survival of 3–5 years after the initial symptomatology. In ALS, motor neurons gradually degenerate and die. Many features of mitochondrial dysfunction are manifested in neurodegenerative diseases, including ALS. Mitochondria have shown to be an early target in ALS pathophysiology and contribute to disease progression. Disruption of their axonal transport, excessive generation of reactive oxygen species, disruptio…
Exponential growth phase cells of the osmotolerant yeast Debaryomyces hansenii are extremely resistant to dehydration stress
2001
Abstract The osmotolerant yeast Debaryomyces hansenii is highly resistant to dehydration stress and this tolerance was more pronounced for cells taken from the exponential growth phase than from the stationary phase. Growth of D. hansenii in medium containing 10% (w v −1 ) NaCl, resulted in an additional increase in cellular resistance to dehydration, which was most marked for stationary phase cells. It is expected that further investigations of the mechanisms behind this exceptional dehydrational tolerance will reveal new approaches for improvement of the quality of dry yeast.