Search results for "STRESS"

Ischemia Cardiaca e Psicosomatica: ruolo di eventi stressanti e stili di vita

2009

Objective: the aim of our study was to evaluate the role of stressful events, lifestyles and various socio-environmental factors in the beginning of ischemic cardiac diseases, together with cardiovascular factors. Materials and methods: 64 patients with recent cardiac ischemia and 64 controls matched 1:1, according to their sex and age, have been evaluated. The study required the filling in of clinico-anamnestic reports and the evaluation of stressful events, using the Holmes Rahe scale. Results: in the 44% of the patients who had a heart ischemia, an emotional striking event occurred few day before, with a 28% incidence of work and family problems. The mean score of the Holmes Social Readj…

The many lives of Hsp10: From Early Pregnancy Factor to Potential Antitumoral Agent. New Proteomic Data and a Review of the Literature Focusing on It…

2008

Does Bacillus thuringiensis Affect the Stress and Immune Responses of Rhynchophorus ferrugineus Larvae, Females, and Males in the Same Way?

2022

Simple Summary Rhynchophorus ferrugineus is a destructive quarantine pest of palm trees, now widely distributed. Although broad-spectrum insecticides are often used to protect palm against R. ferrugineus, there is increasing concern about their effects on the environment and human health, especially where palm trees are located in urban areas. As an environmentally friendly entomopathogen, Bacillus thuringiensis (Bt) has been widely used to prevent other pest infestations. Although Bt products are the most sold bio-insecticides, there are still many interesting features to be investigated in the relationship of Bt and its hosts. We investigated the effect of Bt on larvae, females, and males…

Huippuvalmentajien henkinen hyvinvointi koetuksella jo kauden alla

2022

One More, One More... You Get Stuck" : The Role of Craving in Smartphone-Related Technostress

2022

Smartphones have been integrated into nearly every aspect of human life. Because of them, being entertained, communicating with others, and finding information has never been easier. Even though such possibilities are positive on the surface, the versatile nature of smartphones has also created issues, such as people using them compulsively or excessively. By collecting and analyzing data from 30 semistructured interviews, we explored how users may experience craving unstoppable/uncontrollable desire to use, despite the negative consequences) that make them use smartphones compulsively or excessively. Such use may eventually lead to technostress, which is stress caused by technology use. We…

The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value

2021

AbstractIron is a fundamental nutrient utilized by living cells to support several key cellular processes. Despite its paramount role to sustain cell survival, excess of labile iron availability can inflict severe cell damage via reactive oxygen species generation which, in turn, can promote neoplastic transformation. The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tensions herein present. Moreover, cigarette smoke as well as air pollution particulate can function as vehicles of iron supply, leading to an iron dysregulation condition shown to be crucial in the pathogenesis of several respiratory diseases including lung cancer. Hephaestin (HEPH) bel…

Jauna dihidropiridīna atvasinājuma AV-6-93 efekts uz biomarķiera BDNF ekspresiju stresa modelī žurkām

2015

Stresa izraisītie atmiņas bojājumi ir iemesls jaunu zāļu vielu meklējumiem, kas spētu aizkavēt smadzeņu bojājumus. Mūsu pētījuma mērķis bija noteikt jauna Latvijas Organiskās sintēzes institūtā sintezētās zāļu vielas AV-6-93, kas sastāv no dihidropiridīna un adamantāna atvasinājumiem, ietekmi uz neirotrofā faktora BDNF ekspresiju imobilizācijas stresētām žurkām hipokampā ar Western blota metodi. Petījuma rezultāti rāda, ka imobilizācijas stress ir palielinājis BDNF ekspresiju žurku hipokampā salīdzinājumā ar kontroles hipokampa žurkām, un AV-6-93 piemīt spēja normalizēt BDNF ekspresiju stresēto žurku hipokampā. Mūsu dati rāda, ka nepieciešams turpināt pētīt šī savienojuma molekulāros mehāni…

Metallic nanoparticles exhibit paradoxical effects on oxidative stress and pro-inflammatory response in endothelial cells in vitro

2007

Particulate matter is associated with different human diseases affecting organs such as the respiratory and cardiovascular systems. Very small particles (nanoparticles) have been shown to be rapidly internalized into the body. Since the sites of internalization and the location of the detected particles are often far apart, a distribution via the blood stream must have occurred. Thus, endothelial cells, which line the inner surface of blood vessels, must have had direct contact with the particles. In this study we tested the effects of metallic nanoparticles (Co and Ni) on oxidative stress and proinflammatory response in human endothelial cells in vitro. Exposure to both nanoparticle types…

Kouluhyvinvoinnin yhteys nuorten huoliin siirryttäessä alakoulusta yläkouluun : itsetunto, sukupuoli ja koulutyyppi yhteyttä muuntavina tekijöinä

2017

Tämä tutkimus on osa Jyväskylän yliopiston psykologian laitoksella toteutettua TIKAPUU - tutkimushanketta, jonka tavoitteena on tunnistaa tekijöitä, jotka edistävät oppimista, kouluhyvinvointia sekä onnistunutta siirtymää alakoulusta yläkouluun. Tämän osatutkimuksen tavoitteena oli selvittää kouluhyvinvoinnin yhteyttä nuorten huoliin siirryttäessä alakoulusta yläkouluun. Kouluhyvinvointia tutkittiin nuorten kokemana kouluviihtyvyytenä sekä koulustressin puuttumisena. Ylä- kouluun liittyviä huoliaan nuoret saivat raportoida vapaasti, jonka jälkeen huolet luokiteltiin sisältö- jen perusteella huoliluokkiin. Kouluviihtyvyyden ja koulustressin yhteyttä selvitettiin sekä huolten kokonaismäärään …

Cytoprotective Effect of Idebenone through Modulation of the Intrinsic Mitochondrial Pathway of Apoptosis in Human Retinal Pigment Epithelial Cells E…

2022

Idebenone is a ubiquinone short-chain synthetic analog with antioxidant properties, which is believed to restore mitochondrial ATP synthesis. As such, idebenone is investigated in numerous clinical trials for diseases of mitochondrial aetiology and it is authorized as a drug for the treatment of Leber’s hereditary optic neuropathy. Mitochondria of retinal pigment epithelium (RPE) are particularly vulnerable to oxidative damage associated with cellular senescence. Therefore, the aim of this study was to explore idebenone’s cytoprotective effect and its underlying mechanism. We used a human-RPE cell line (ARPE-19) exposed to idebenone pre-treatment for 24 h followed by conditions …