Search results for "SUBSTITUTION"
showing 10 items of 536 documents
Zasięg korporacyjnego upoważnienia aplikanta do zastępstwa
2023
Upoważnienie aplikanta do zastępstwa funkcjonuje od dawna. Jako że ma charakter tylko albo aż upoważnienia korporacyjnego, stąd też na tym tle jest ono różnie postrzegane. Do tego dochodzą dylematy w zakresie pełnienia przez profesjonalnego pełnomocnika funkcji kuratora, a także kwestia udzielenia upoważnienia do zastępstwa dla aplikanta czy nawet substytucji procesowej dla innego profesjonalnego pełnomocnika w osobie adwokata lub radcy prawnego. Wielość wątków z uwagi na szerokie spektrum aktywności aplikanta, co wiązać należy z odbywaną przez niego aplikacją adwokacką albo radcowską, pociąga za sobą konieczność umiejscowienia go w szeroko rozumianym wymiarze sprawiedliwości jako osoby qua…
Bis-organosilane applications and synthesis
2017
Tutkielman kirjallisuusosuudessa perehdytään organofunktionaalisiin silaaneihin. Näitä yhdisteitä käytetään kytkentäaineina komposiittien valmistuksessa sekä monessa muussa sovelluksessa, kuten hydrofobisten ja hydrofiilisten pintojen muodostamiseen, kuivausaineina, ulkoisena elektroniluovuttajana polymeroinnissa, sekä kosteuskovettuvien silaanimodifioitujenpolymeeriliimojen (SMP) kovettumisreaktiossa. Silaanien kosteuskovettuminen johtuu pii-atomiin (Si) sitoutuneiden ryhmien hydrolysoitumisesta kosteuden vaikutuksesta, jolloin syntyy silanoli-ryhmiä (Si-OH), jotka voivat edelleen kondensoitua keskenään muodostaen siloksaanisidoksia (Si-O-Si) tai sidoksia pintojen hydroksyyliryhmien kanssa…
L'impact de la substitution de marques sur l'évaluation et l'intention d'achat du produit.
2008
L'objectif de cet article est de comprendre l'impact de la substitution de marques sur l'évaluation et l'intention d'achat du produit. À cette fin, les différents types de substitutions de marques sont présentés. Puis, à partir des travaux relatifs à l'extension de marque et au co-marquage, des variables susceptibles d'expliquer l'évolution de l'évaluation et de l'intention d'achat d'un produit qui a changé de nom de marque sont proposées. L'étude empirique met en évidence que cinq variables influencent l'évolution de l'évaluation et de l'intention d'achat du produit qui a changé de nom de marque: (1) la similarité entre la marque de substitution et la marque initiale, (2) la cohérence per…
Alcohol and Cannabis Consumption Does Not Diminish Cure Rates in a Real-World Cohort of Chronic Hepatitis C Virus Infected Patients on Opioid Substit…
2019
Background: The importance of alcohol and cannabis consumption for the effectiveness of treatment of chronic hepatitis C virus (HCV) infection with direct acting antivirals (DAAs) in people on opioid substitution therapy (OST) has not been investigated in detail. Methods: We investigated sustained virological response (SVR) rates and proportion of lost to follow-up (LTFU) between OST (n = 739) and non-OST patients (n = 7008) in the German Hepatitis C-Registry (Deutsches Hepatitis C-Register, DHC-R), which is a national multicenter prospective non-interventional real-world registry. Non-OST patients comprised patients with former/current drug use (non-OST/DU; n = 1500) and patients never con…
Rapid Synthesis of Unsymmetrical Sulforhodamines Through Nucleophilic Amination of a Monobrominated Sulfoxanthene Dye
2014
A transition-metal-free method for the synthesis of N-substituted unsymmetrical sulforhodamine fluorophores from an unusual monobrominated sulfoxanthene dye and primary or secondary amines by direct SNAr-type reactions is presented. The simplicity and effectiveness of this “postamination” procedure were demonstrated through the rapid preparation of a library of multifunctional red-emitting rhodamine analogues. Some of these analogues are equipped with a reactive handle and retain the two water-solubilizing sulfonic acid moieties of the starting halogenated derivative; this makes them ideal candidates for biolabeling applications. The potential utility of this expeditious strategy to finely …
Insights into the Synthesis and the Solution Behavior ofmeso-Aryloxy- and Alkoxy-Substituted Porphyrins
2015
meso-RO-appended (R = alkyl, aryl) porphyrins bearing one or two OR substituents at the tetrapyrrolic macrocycle were synthesized in good yields from 5,15-dibromo-10,20-diphenylporphyrins 2H(Br2DPP), Ni(Br2DPP) and Zn(Br2DPP) using an SNAr reaction. By varying the solvent, the base, the temperature, and the time of the reaction, the optimum conditions were established, and the selective introduction of one or two meso-RO substituents at the periphery of the macrocycle was achieved. Moreover, monofunctionalization of Ni(Br2DPP) according to an SNAr reaction was used as a key step for the synthesis of rarely explored unsymmetrical porphyrinyl alkyl ethers. 1H NMR studies of these ethers in CD…
Methacrylate monolithic columns functionalized with epinephrine for capillary electrochromatography applications.
2013
Epinephrine-bonded polymeric monoliths for capillary electrochromatography (CEC) were developed by nucleophilic substitution reaction of epoxide groups of poly(glycidyl-methacrylate-co-ethylenedimethacrylate) (poly(GMA-co-EDMA)) monoliths using epinephrine as nucleophilic reagent. The ring opening reaction under dynamic conditions was optimized. Successful chemical modification of the monolith surface was ascertained by in situ Raman spectroscopy characterization. In addition, the amount of epinephrine groups that was bound to the monolith surface was evaluated by oxidation of the catechol groups with Ce(IV), followed by spectrophotometric measurement of unreacted Ce(IV). About 9% of all th…
Electrochemical study on (NN)Fe3 (CO)9 ((NN) = 2,3-diazanorbornene) and related compounds. A new example of activation of carbon monoxide replaceme…
1985
Abstract The compound (NN)Fe 3 (CO) 9 ( 1 ) in tetrahydrofuran undergoes two reversible one-electron reduction processes in cyclic voltammetry at the platinum electrode. A rapid electron transfer-catalyzed reaction occurs when 1 is reduced in the presence of L (L = P(OMe) 3 ) and this gives (NN)Fe 3 (CO) 8 L ( 2 ), quantitatively. Only an electron-induced nucleophilic substitution is observed for compound 2 under the same conditions, yielding (NN)Fe 3 (CO) 7 L 2 , which undergoes a similar reaction but with much lower efficiency, to give (NN)Fe 3 (CO) 6 L 3 .
Screening of ligands for the Ullmann synthesis of electron-rich diaryl ethers
2012
In the search for new ligands for the Ullmann diaryl ether synthesis, permitting the coupling of electron-rich aryl bromides at relatively low temperatures, 56 structurally diverse multidentate ligands were screened in a model system that uses copper iodide in acetonitrile with potassium phosphate as the base. The ligands differed largely in their performance, but no privileged structural class could be identified.
Synthesis of cyclic dipeptide templates, their incorporation into peptides and studies on their conformational and biological properties.
2009
This study investigated the diastereoselective synthesis of three dipeptide templates 1, 2 and 3, which may be regarded as conformationally restricted analogs of H-Gly-Xaa-OH, in which Xaa constitutes an aromatic amino acid. Bond formation between α-C of Gly and the aromatic moiety was achieved by proton-catalyzed intramolecular electrophilic aromatic substitution. The absolute configuration of the dipeptide templates was determined by single-crystal X-ray crystallography or by nuclear Overhauser enhancement measurements. A protective group strategy was elaborated to allow their incorporation into peptide sequences by liquid phase as well as by solid-phase peptide synthesis. The templates w…