Search results for "SUPPLEMENTARY"
showing 10 items of 51 documents
Epigenomic k-mer dictionaries: shedding light on how sequence composition influences in vivo nucleosome positioning
2014
Abstract Motivation: Information-theoretic and compositional analysis of biological sequences, in terms of k-mer dictionaries, has a well established role in genomic and proteomic studies. Much less so in epigenomics, although the role of k-mers in chromatin organization and nucleosome positioning is particularly relevant. Fundamental questions concerning the informational content and compositional structure of nucleosome favouring and disfavoring sequences with respect to their basic building blocks still remain open. Results: We present the first analysis on the role of k-mers in the composition of nucleosome enriched and depleted genomic regions (NER and NDR for short) that is: (i) exhau…
Libre circulation des travailleurs dans l'Union Européenne et tutelle des droits individuels de retraite complémentaire: un chantier inachevé
2013
Freedom of movement of workers within the EU implies adequate regulation of risks incurred by workers on the occasion of the exercise of this freedom. Among these risks, there is the possibility for community workers to lose or at least find themselves unable to give their supplementary retirement pension individual rights an unitary and continuous character when they decide to settle in another member State. What are the legislative solutions already proposed by the Community legislature and even those expected by community workers to be protected from these dangers? Provide a draft answer to this question is the main concern of this work.
Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson's disease.
2020
Abstract The disruption of pathologically enhanced beta oscillations is considered one of the key mechanisms mediating the clinical effects of deep brain stimulation on motor symptoms in Parkinson’s disease. However, a specific modulation of other distinct physiological or pathological oscillatory activities could also play an important role in symptom control and motor function recovery during deep brain stimulation. Finely tuned gamma oscillations have been suggested to be prokinetic in nature, facilitating the preferential processing of physiological neural activity. In this study, we postulate that clinically effective high-frequency stimulation of the subthalamic nucleus imposes cross-…
rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease
2005
The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.
The role of left supplementary motor area in grip force scaling
2013
Skilled tool use and object manipulation critically relies on the ability to scale anticipatorily the grip force (GF) in relation to object dynamics. This predictive behaviour entails that the nervous system is able to store, and then select, the appropriate internal representation of common object dynamics, allowing GF to be applied in parallel with the arm motor commands. Although psychophysical studies have provided strong evidence supporting the existence of internal representations of object dynamics, known as "internal models", their neural correlates are still debated. Because functional neuroimaging studies have repeatedly designated the supplementary motor area (SMA) as a possible …
High-frequency rTMS improves time perception in Parkinson disease.
2004
Patients with Parkinson disease (PD) are impaired in time processing. The authors investigated the effects of high-frequency (5 Hz) repetitive transcranial magnetic stimulation (rTMS) in patients with PD performing a time reproduction task. The authors found significant improvement in time processing induced by rTMS when trains were applied over the right dorsolateral prefrontal cortex (DLPFC) but not over the supplementary motor area, suggesting that the circuit involving the basal ganglia and the DLPFC might constitute the neural network subserving time perception.
Clima subártico para os primeiros Homo sapiens na Europa
2021
Description
Title: The Emergency Medicine Facing the Challenge of Open Science
2020
This article belongs to the Special Issue Data Reuse for Sustainable Development Goals.
The genus Galumna in Nepalese oribatid mite fauna, with notes on systematic placement of some species (Acari, Oribatida, Galumnidae)
2014
The oribatid mite genus Galumna (Oribatida, Galumnidae) is recorded for the first time in Nepal. A new species, Galumna tetraporosa sp. n., is described from soil of secondary mixed broadleaved forest. It is most similar morphologically to G. tokyoensis Aoki, 1966 and G. valida Aoki, 1994, however, it differs from both by the absence of interlamellar setae and the presence of two pairs of notogastral porose areas Aa. Galumna granalata Aoki, 1984 is redescribed on the basis of specimens from Nepal. Galumna floridae (Jacot, 1929) and G. hexagona Balogh, 1960 are transferred to the genus Notogalumna; G. mauritii Mahunka, 1978 is transferred to the genus Dimidiogalumna.
Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease
2021
Highlights • Parallel subnetworks are affected in bradykinesia. • The primary motor and the premotor cortex are common nodes with task-specificity. • Beta activity decreases, gamma activity increases with improvement of bradykinesia. • Subthalamic stimulation reduces beta, increases gamma power in ipsilateral cortex. • Subnetworks act with frequency-specific oscillations.