Search results for "Sang"

Network meta-analysis of randomized trials in multiple myeloma: Efficacy and safety in frontline therapy for patients not eligible for transplant

2022

The treatment scenario for newly-diagnosed transplant-ineligible multiple myeloma patients (NEMM) is quickly evolving. Currently, combinations of proteasome inhibitors (PI) and/or immunomodulatory drugs (IMiD) +/- the monoclonal antibody Daratumumab are used for first-line treatment, even if head-to-head comparisons are lacking. To compare efficacy and safety of these regimens, we performed a network meta-analysis (NMA) of 27 phase 2/3 randomized trials including a total of 12935 patients and 23 different schedules. Four efficacy/outcome and one safety indicators were extracted and integrated to obtain (for each treatment) the surface under the cumulative ranking-curve (SUCRA), a metric use…

ABSOLUTE LYMPHOCYTE COUNT AS PREDICTOR FOR SURVIVAL IN NEWLY DIAGNOSED ELDERLY PATIENTS WITH MULTIPLE MYELOMA

2011

ABSOLUTE LYMPHOCYTE COUNT IS NOT A PREDICTOR FOR SURVIVAL IN NEWLY DIAGNOSED ELDERLY PATIENTS WITH MULTIPLE MYELOMA. FINAL RESULTS OF A MULTICENTER S…

2012

Does δ-sarcoglycan-associated autosomal-dominant cardiomyopathy exist?

2009

In this study we clinically and genetically characterize a consanguineous family with a homozygous novel missense mutation in the delta-sarcoglycan gene and a second delta-sarcoglycan mutation that has previously been reported to cause severe autosomal-dominant dilated cardiomyopathy. We identified a novel missense mutation in exon 6 (p.A131P) of the delta-sarcoglycan gene, which in a homozygous state leads to the clinical picture of a limb girdle muscular dystrophy. In four heterozygous carriers for the mutation, aged 3-64 years, a second sequence variant in exon 6 (p.S151A) of the delta-sarcoglycan gene was detected on the other allele. This second missense change had previously been repo…

Phenotypic spectrum and genomics of undiagnosed arthrogryposis multiplex congenital

2022

BackgroundArthrogryposis multiplex congenita (AMC) is characterised by congenital joint contractures in two or more body areas. AMC exhibits wide phenotypic and genetic heterogeneity. Our goals were to improve the genetic diagnosis rates of AMC, to evaluate the added value of whole exome sequencing (WES) compared with targeted exome sequencing (TES) and to identify new genes in 315 unrelated undiagnosed AMC families.MethodsSeveral genomic approaches were used including genetic mapping of disease loci in multiplex or consanguineous families, TES then WES. Sanger sequencing was performed to identify or validate variants.ResultsWe achieved disease gene identification in 52.7% of AMC index pati…

Mediterranean spotted fever: clinical and laboratory characteristics of 415 Sicilian children

2006

Abstract Background Mediterranean spotted fever (MSF) is an acute febrile, zoonotic disease caused by Rickettsia conorii and transmitted to humans by the brown dogtick Rhipicephalus sanguineus. Nearly four hundred cases are reported every year (mainly from June to September) on the Italian island of Sicily. The aim of the study was to analyze the clinical and laboratory characteristics of patients with MSF and the efficacy of the drugs administered. Methods Our study was carried out on 415 children with MSF, during the period January 1997 – December 2004, at the "G. Di Cristina" Children's hospital in Palermo, Sicily, Italy. On admission patients' clinical history, physical and laboratory e…

La flebotomía en disputa. Una polémica entre dos escuelas médicas, Barcelona y Valencia, a finales del siglo XVI

2020

La flebotomía era una técnica profiláctica y terapéutica propia del galenismo que se empleaba para prevenir o curar diversas afecciones morbosas. Consistía en la sección de una vena periférica, generalmente del brazo, hasta conseguir la emisión de cierta cantidad de sangre. Técnica controvertida desde la Antigüedad, en la Baja Edad Media se teorizó sobre sus indicaciones, los procedimientos que debían seguirse en cada caso, los lugares corporales de su administración, los días hábiles o prohibidos, las circunstancias ambientales que debían concurrir, incluidos los influjos astrales, la frecuencia con que tenía que realizarse, la cantidad de la emisión de sangre, etc. Durante la segunda mita…

"Thérèse Raquin" d'Émile Zola : la notion de tempérament entre l'héritage antique et l'apport de la physiologie du XIXe siècle

2020

Therese Raquin, Zola’s first important work, is based on the modern version of the old physiological theory of “temperaments”, e.g. the combination of four cardinal “humours” that determine a man’s physical and mental constitution. Through the story of two murderers, an adulterous woman and her lover who kill the woman’s husband, the author shows the mutual influence of two temperaments considered in the 19th century as more important than all the others: sanguine and melancholic (or nervous). The novel intends to “verify” a theory dealing with the consequences of each type of temperament for people’s behaviour, their relationships and their internal life.

Podręcznik do nauki śpiewu Gesanglehre Bernharda Kothego (1821–1897)

2020

Singing is recognized as the most primary form of human contact with music. This art is an important element of the development,education and upbringing of the young generation. Inviting a child to the world of music lies first with the parent and then with the teacher. The popularity of various types of textbooks, songbooks or guidebooks indicates a great interest in music education. Although singing cannot be learned from a book, such studies are a great help. The author of the textbook Gesanglehre guided the idea of introducing the child to the world of music and showing the right ways of making music. This position was developed by Bernhard Kothe in 1872, and later perfected it in subse…

Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants

2017

Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of rai…