Search results for "Science & Technology"

showing 10 items of 723 documents

Pan-cancer analysis of whole genomes

2020

Publisher's version (útgefin grein)

Maletert promoter mutationsCancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]DNA Mutational AnalysisNormal tissuesystematic analysisGermlineTranscriptome0302 clinical medicineAetiologyCàncerCellular SenescenceCancer0303 health sciencesdna-damageMassive parallel sequencingPan cancerREARRANGEMENTSHigh-Throughput Nucleotide SequencingGenomicsSciences bio-médicales et agricolesTelomereCOMPREHENSIVE3. Good healthTERT PROMOTER MUTATIONSsignatures030220 oncology & carcinogenesisScience & Technology - Other TopicsErfðarannsóknirHuman:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]EvolutionRNA SplicingGenomicsArticleEvolution MolecularStructural variationRC025403 medical and health sciencesSDG 3 - Good Health and Well-beingGeneticgenomicsSYSTEMATIC ANALYSISGeneticsGenomics--Databases.HumansGenetic TestingMolecular BiologySIGNATURESWhole genome sequencing1000 MultidisciplinaryChromothripsisScience & TechnologyRC0254 Neoplasms. Tumors. Oncology (including Cancer)Information DisseminationResearchInstitutes_Networks_Beacons/mcrcPreventionBiology and Life SciencesMolecularOncogenesCloud Computingmedicine.diseaseGenòmicaCompute cloudsMutation570 Life sciences; biologyCOMPREHENSIVE CHARACTERIZATIONGenèticaWhole Genome Sequencing--methodsBackground informationDNA Mutational Analysis ; Evolution ; Genetic / genetics ; Genome ; Genomics ; Germ-Line Mutation / genetics ; High-Throughput Nucleotide Sequencing ; Human / genetics ; Humans ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumMedizinGenomeWhole-genomeGenome mappingNeoplasms2.1 Biological and endogenous factorsPromoter Regions GeneticCàncer -- Aspectes genèticsTelomeraseGeneticsWomen's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]MultidisciplinaryChromothripsisGenomeManchester Cancer Research Centregenomics cancer profiling3rd-DAS10124 Institute of Molecular Life SciencesWomen's cancers Radboud Institute for Health Sciences [Radboudumc 17]Multidisciplinary SciencesParallel sequencingICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumFemaleprofilingMedical GeneticsEngineering sciences. TechnologyBiotechnologyGeneral Science & TechnologyThe Cancer Genome Atlas610 Medicine & healthComputational biologyQH426 GeneticsBiologyConsortium of the International Cancer Genome ConsortiumPromoter RegionsGermline mutationPan-cancer analysisKrabbameinsrannsóknirmedicinecancerddc:610QH426Germ-Line MutationMedicinsk genetikKrabbamein030304 developmental biologyCell ProliferationLANDSCAPEGenome Humancomprehensive characterizationPan-cancer analysis of whole genomesPoint mutationHuman GenomeCancerReproducibility of ResultsSOMATIC MUTATIONSEVOLUTIONCancer sequencing Chromothripsis telomereDNA-DAMAGEMutagenesisPATTERNS3111 BiomedicineCHARACTERIZATION
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Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO2 Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutica…

2018

The bicarbonate buffer capacity is usually considered in a phase-homogeneous system, at equilibrium, with no CO2 transfer between the liquid buffer phase and another phase. However, typically, an in vitro bicarbonate buffer-based system is a phase-heterogeneous system, as it entails continuously sparging (bubbling) the dissolution medium with CO2 in a gas mixture, at constant ratio, to maintain a constant partial pressure of CO2 (g) and CO2(aq) molarity at a prescribed value, with CO2 diffusing freely between the gas and the aqueous phases. The human gastrointestinal tract is also a phase-heterogeneous system, with CO2 diffusing across the mucosal membrane into the mesenteric arterial blood…

Mass transportacid and base dissolutionPHBicarbonatePharmaceutical Sciencebicarbonate02 engineering and technologyResearch & Experimental Medicinebuffer capacity030226 pharmacology & pharmacyBuffer (optical fiber)03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDrug DiscoveryPharmacology & PharmacyPERMEABILITYVOLUMESRELEASEScience & TechnologyChemistryin vivo gastrointestinal bufferingDYNAMIC DISSOLUTIONPROFILES021001 nanoscience & nanotechnologyPRODUCTSphase-heterogeneousChemical engineeringMedicine Research & ExperimentalMolecular MedicineSECRETIONCO20210 nano-technologyLife Sciences & BiomedicineBEHAVIORTRACT
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The effect of prolonged storage time on asphalt rubber binder properties

2019

Abstract This study wants to provide fundamental understanding of prolonged storage time on asphalt rubber binder properties by performing an investigation on the variation of conventional properties, rheology and morphology of four asphalt rubbers maintained at 180 °C in low shear for different digestion/storage times up to 48 h. The analysed asphalt rubbers were manufactured by combining two different asphalt binder grades, pen 35/50 and pen 50/70, with both cryogenic and ambient crumb rubber. Results have shown that keeping asphalt rubber agitated at the above mentioned processing conditions, up to 48 h, is significantly detrimental when an ambient crumb rubber is used, while it seems no…

Materials science0211 other engineering and technologies02 engineering and technologyAsphalt rubberNatural rubberRheologyEngenharia e Tecnologia::Engenharia Civil021105 building & constructionDigestion timeGeneral Materials ScienceCrumb rubberComposite materialCivil and Structural EngineeringCrumb rubberScience & TechnologyBuilding and Construction021001 nanoscience & nanotechnologyAsphaltvisual_art:Engenharia Civil [Engenharia e Tecnologia]visual_art.visual_art_mediumStorage stabilityAsphalt rubber Digestion time Storage stability Rheology Scanning electron microscopy Crumb rubber0210 nano-technologyRheologyScanning electron microscopy
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The role of Ga and Bi doping on the local structure of transparent zinc oxide thin films

2021

The experiment at HASYLAB/DESY was performed within the project I-20180036 EC. The research leading to this result has been supported by the project CALIPSOplus under the Grant Agreement 730872 from the EU Framework Programme for Research and Innovation HORIZON 2020. Filipe Correia is grateful to the Fundação para a Ciência e Tecnologia (FCT, Portugal) for the Ph.D. Grant SFRH/BD/111720/2015. Joana Ribeiro is grateful to the Project WinPSC - POCI-01-0247-FEDER-017796, for the research grant from the Agência Nacional de Inovação, co-funded by the European Regional Development Fund (ERDF), through the Operational Programme for Competitiveness and Internationalisation (COMPETE 2020), under the…

Materials scienceAbsorption spectroscopyCiências Naturais::Ciências FísicasThin films:Ciências Físicas [Ciências Naturais]:Chemical engineering [Engineering and technology]02 engineering and technology010402 general chemistry01 natural sciencessymbols.namesakeX-ray photoelectron spectroscopy:Engenharia química [Ciências da engenharia e tecnologias]Zinc oxide:NATURAL SCIENCES:Physics [Research Subject Categories]Materials ChemistryThin filmChemistry Chemical engineeringWurtzite crystal structureX-ray absorption spectroscopyScience & TechnologyMechanical EngineeringThermoelectricMetals and AlloysSputteringX-ray absorption spectroscopySputter deposition021001 nanoscience & nanotechnologyQuímica Engenharia química0104 chemical sciencesCrystallography13. Climate actionMechanics of Materialsddc:540Raman spectroscopysymbolsGrain boundary0210 nano-technologyRaman spectroscopy
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Influence of Nb-doping on the local structure and thermoelectric properties of transparent TiO2:Nb thin films

2020

The experiment at HASYLAB/DESY was performed within the project I-20180036 EC. The research leading to this result has been supported by the project CALIPSOplus under the Grant Agreement 730872 from the EU Framework Programme for Research and Innovation HORIZON 2020. Filipe Correia is grateful to the Fundação para a Ciência e Tecnologia (FCT, Portugal) for the Ph.D. Grant SFRH/BD/111720/2015 . Joana Ribeiro is grateful to the Project WinPSC - POCI-01-0247-FEDER-017796, for the research grant, co-funded by the European Regional Development Fund (ERDF) , through the Operational Programme for Competitiveness and Internationalisation (COMPETE 2020), under the PORTUGAL 2020 Partnership Agreement…

Materials scienceAbsorption spectroscopyCiências Naturais::Ciências FísicasThin films:Ciências Físicas [Ciências Naturais]Analytical chemistry02 engineering and technologyNb [TiO2]010402 general chemistry01 natural sciencesSputteringSeebeck coefficientThermoelectric effect:NATURAL SCIENCES:Physics [Research Subject Categories]Materials ChemistryThin filmNb 2 [TiO]Science & TechnologyDopantExtended X-ray absorption fine structureThermoelectricMechanical EngineeringMetals and AlloysSputtering540021001 nanoscience & nanotechnologyXANESXANES0104 chemical sciencesTiO :Nb 2EXAFSMechanics of Materialsddc:540TiO2:NbSeebeck0210 nano-technologyJournal of Alloys and Compounds
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Linear assembly of lead bromide-based nanoparticles inside lead(ii) polymers prepared by mixing the precursors of both the nanoparticle and the polym…

2019

Mixing precursors of lead(ii) polymers with those of lead bromide-based nanoparticles (CH3NH3PbBr3 perovskites or PbBr2), at room temperature and in the presence of cyclohexanemethylammonium bromide, generated colloidal nanocomposites which, when deposited on a hydrophobic surface led to long, one-dimensional, ordered and well-defined architectures. ispartof: CHEMICAL COMMUNICATIONS vol:55 issue:20 pages:2968-2971 ispartof: location:England status: published

Materials scienceChemistry MultidisciplinaryLead bromideMixing (process engineering)Nanoparticle010402 general chemistry01 natural sciencesCatalysischemistry.chemical_compoundColloidPHOTOLUMINESCENCE BLINKINGBromidePEROVSKITE NANOPARTICLESMaterials ChemistryCH3NH3PBBR3chemistry.chemical_classificationNanocompositeScience & Technology010405 organic chemistryMetals and AlloysGeneral ChemistryPolymer0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsChemistryNANOCRYSTALSchemistryChemical engineeringPhysical SciencesLUMINESCENCECeramics and CompositesFORCES
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Origin of the Chemiresistive Response of Ultrathin Films of Conductive Metal–Organic Frameworks

2018

Conductive metal-organic frameworks are opening new perspectives for the use of these porous materials for applications traditionally limited to more classical inorganic materials, such as their integration into electronic devices. This has enabled the development of chemiresistive sensors capable of transducing the presence of specific guests into an electrical response with good selectivity and sensitivity. By combining experimental data with computational modelling, a possible origin for the underlying mechanism of this phenomenon in ultrathin films (ca. 30 nm) of Cu-CAT-1 is described. ispartof: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION vol:57 issue:46 pages:15086-15090 ispartof: location…

Materials scienceChemistry MultidisciplinaryQuímica organometàl·licaNanotechnology02 engineering and technology010402 general chemistry01 natural sciencesCatalysischemiresistive sensingmolecular devicesELECTRICAL-CONDUCTIVITYultrathin filmsElectronicsmetal-organic frameworksElectrical conductorScience & Technologyelectrical conductivity010405 organic chemistryGeneral ChemistryConductivitat elèctricaGeneral Medicine021001 nanoscience & nanotechnology0104 chemical sciencesChemistryPhysical SciencesMetal-organic frameworkInorganic materials0210 nano-technologyPorous mediumAngewandte Chemie
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Asphalt surface mixtures with improved performance using waste polymers via dry and wet processes

2017

"Published online: June 29, 2017"

Materials scienceDry process0211 other engineering and technologies02 engineering and technologyMixture performance.Wet proce021105 building & constructionSettore ICAR/04 - Strade Ferrovie Ed AeroportiGeneral Materials ScienceCivil and Structural EngineeringWaste polymerschemistry.chemical_classificationDry proceScience & TechnologyWaste managementBuilding and ConstructionPolymer021001 nanoscience & nanotechnologyImproved performanceWet processWaste polymerchemistryMechanics of MaterialsAsphaltMixture performance0210 nano-technologyAsphalt modification
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Reliability of manual segmentation of cornea, contact lens and tear film using a high-resolution OCT

2015

In this study, we aimed to evaluate the intra/inter-session and intra/inter-observer variability of manual segmentation of thickness of the pre-lens tear film, contact lens (CL), post-lens tear film, epithelium, bowman’s layer, stroma and the whole cornea and CLs with a flat and a steep fit, using a commercial high-resolution spectral domain optical coherence tomographer (OCT). Two different observers obtained three repeated measures in two separate sessions. A high correlation was found between the values obtained by the two different observers, except for the thinner layers, epithelium, and Bowman’s layer. Inter-observer analysis showed a high consistency in the measurements obtained by b…

Materials scienceManual layer segmentationOpticsCLs upper limitsOptical coherence tomographyCorneamedicineEpithelial thicknessRepeatabilityScience & Technologymedicine.diagnostic_testOptical coherence tomographybusiness.industryResolution (electron density)RepeatabilityAtomic and Molecular Physics and Opticseye diseasesTear film thicknessContact lensCorneal thicknessmedicine.anatomical_structureManual segmentationsense organsbusinessBiomedical engineering
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Structure and chemical bonds in reactively sputtered black Ti–C–N–O thin films

2011

The evolution of the nanoscale structure and the chemical bonds formed in Ti–C–N–O films grown by reactive sputtering were studied as a function of the composition of the reactive atmosphere by increasing the partial pressure of an O2+N2 gas mixture from 0 up to 0.4 Pa, while that of acetylene (carbon source) was constant. The amorphisation of the films observed by transmission electron microscopy was confirmed by micro- Raman spectroscopy, but it was not the only effect associated to the increase of the O2+N2 partial pressure. The chemical environment of titanium and carbon, analysed by X-ray photoemission spectroscopy, also changes due to the higher affinity of Ti towards oxygen and nitro…

Materials sciencePhotoemission spectroscopyReactive sputteringAnalytical chemistrychemistry.chemical_element02 engineering and technology01 natural sciencesElectron spectroscopyX-ray photoelectron spectroscopy0103 physical sciencesMaterials Chemistry010302 applied physicsTitanium oxy-carbo-nitridesScience & TechnologyMetals and AlloysSurfaces and InterfacesPartial pressure021001 nanoscience & nanotechnologyX-ray photoelectron SpectroscopyTransmission electron Microscopy3. Good healthSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsCarbon filmAmorphous carbonchemistryRaman spectroscopy0210 nano-technologyCarbonTitanium
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