Search results for "Science & Technology"
showing 10 items of 723 documents
A model for estimating the health economic impact of earlier diagnosis of chronic thromboembolic pulmonary hypertension
2021
Background Diagnostic delay of chronic thromboembolic pulmonary hypertension (CTEPH) exceeds 1 year, contributing to higher mortality. Health economic consequences of late CTEPH diagnosis are unknown. We aimed to develop a model for quantifying the impact of diagnosing CTEPH earlier on survival, quality-adjusted life-years (QALYs) and healthcare costs. Material and methods A Markov model was developed to estimate lifelong outcomes, depending on the degree of delay. Data on survival and quality of life were obtained from published literature. Hospital costs were assessed from patient records (n=498) at the Amsterdam UMC – VUmc, which is a Dutch CTEPH referral center. Medication costs were ba…
The disease-specific clinical trial network for primary ciliary dyskinesia: PCD-CTN
2022
Primary ciliary dyskinesia; Rare genetic disorder; Lung diseases Discinesia ciliar primaria; Trastorno genético raro; Enfermedades pulmonares Discinesia ciliar primària; Trastorn genètic rar; Malalties pulmonars Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by impaired mucociliary clearance leading to irreversible lung damage. In contrast to other rare lung diseases like cystic fibrosis (CF), there are only few clinical trials and limited evidence-based treatments. Management is mainly based on expert opinions and treatment is challenging due to a wide range of clinical manifestations and disease severity. To improve clinical and translational research and facili…
Continuing professional development: introducing the ERS International Certificate in Respiratory Sleep Medicine
2017
What is the greatest challenge in the delivery of quality care to respiratory disease patients? Is it lack of resources, avoidable harm to patients, or more complex disease presentation? Healthcare delivery has been in the media spotlight in recent months across many countries and the question of how to deliver safe, effective and efficient care to patients remains at the forefront of political agendas at a national level. Education is the passport to the future and the European Respiratory Society (ERS) is in the unique position of being able to work with the most respected respiratory experts internationally in order to design and deliver educational activities to raise standards of train…
A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample
2011
Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium). OBJECTIVES: To comprehensively analyse previously reported genetic associations with lung function measures, and to investigate whether single nucleotide polymorphisms (SNPs) in these genomic regions…
Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B…
2016
Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organizatio…
The diamond partial order in rings
2013
In this paper we introduce a new partial order on a ring, namely the diamond partial order. This order is an extension of a partial order defined in a matrix setting in [J.K. Baksalary and J. Hauke, A further algebraic version of Cochran's theorem and matrix partial orderings, Linear Algebra and its Applications, 127, 157--169, 1990]. We characterize the diamond partial order on rings and study its relationships with other partial orders known in the literature. We also analyze successors, predecessors and maximal elements under the diamond order.
Special elements in a ring related to Drazin inverses
2013
In this paper, the existence of the Drazin (group) inverse of an element a in a ring is analyzed when amk = kan, for some unit k and m; n 2 N. The same problem is studied for the case when a* = kamk-1 and for the fk; s+1g-potent elements. In addition, relationships with other special elements of the ring are also obtained
Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
2017
Three new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η 5 -MeCp)(PPh 3 ) 2 Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η 5 -MeCp)(PPh 3 )(L1)][CF 3 SO 3 ] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4–6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM46…
Measurement of the chi(b) (3 P) mass and of the relative rate of chi(b1) (1 P) and chi(b2) (1 P) production
2014
The production of $\chi_b$ mesons in proton-proton collisions is studied using a data sample collected by the LHCb detector, at centre-of-mass energies of $\sqrt{s}=7$ and $8$ TeV and corresponding to an integrated luminosity of 3.0 fb$^{-1}$. The $\chi_b$ mesons are identified through their decays to $\Upsilon(1S)\gamma$ and $\Upsilon(2S)\gamma$ using photons that converted to $e^+e^-$ pairs in the detector. The $\chi_b(3P)$ meson mass, and the relative prompt production rate of $\chi_{b1}(1P)$ and $\chi_{b2}(1P)$ mesons as a function of the $\Upsilon(1S)$ transverse momentum in the $\chi_b$ rapidity range 2.0< $y$<4.5, are measured. Assuming a mass splitting between the $\chi_{b1}(3P)$ an…
A search for new physics in dijet mass and angular distributions in pp collisions at [subscript √s=7] TeV measured with the ATLAS detector
2011
A search for new interactions and resonances produced in LHC proton–proton (pp) collisions at a centre-of-mass energy ps = 7 TeV was performed with the ATLAS detector. Using a dataset with an integrated luminosity of 36 pb−1, dijet mass and angular distributions were measured up to dijet masses of 3.5 TeV and were found to be in good agreement with Standard Model predictions. This analysis sets limits at 95% CL on various models for new physics: an excited quark is excluded for mass between 0.60 and 2.64 TeV, an axigluon hypothesis is excluded for axigluon masses between 0.60 and 2.10 TeV and quantum black holes are excluded in models with six extra space–time dimensions for quantum gravity…