Search results for "Sclerosis"
showing 10 items of 1583 documents
Synthesis of organometallic glycopeptides and electrochemical studies to detect autoantibodies in multiple sclerosis patients' sera
2009
Feliciana Real-Fernandez, Amelie Chamois-Colson, Jerome Bayardon, Francesca Nuti, Elisa Peroni, Maria R. Moncelli, Rita Meunier-Prest, Sylvain Juge and Anna Maria Papini Laboratory of Peptide & Protein Chemistry & Biology, Polo Scientifico, University of Florence, I-50019 Sesto Fiorentino (FI), Italy; Laboratoire de Synthese et d’Electrosynthese Organometalliques (LSEO), Universite de Bourgogne, 21068, Dijon, France
Prevalence of extracranial venous abnormalities: results from a sample of 586 multiple sclerosis patients
2011
The aim of this study was to assess the prevalence of chronic cerebrospinal venous insufficiency in an unselected cohort of multiple sclerosis (MS) patients. A total of 586 patients with clinically defined MS underwent catheter venography of the internal jugular veins, brachiocephalic veins and azygos vein. The following findings were regarded as pathologic: no outflow, slowed outflow, reversal of flow direction, prestenotic dilation accompanied by impaired outflow, outflow through collaterals, intraluminal structures obstructing the vein, hypoplasia, agenesia or significant narrowing of the vein. Venous abnormalities were found in 563 patients (96.1%). Lesions in one vein were found in 43.…
Bempedoic acid as adjunct for traditional lipid-lowering therapy in patients with hyperlipidaemia
2020
Statin therapy has been the cornerstone for the reduction of cholesterol and circulating low-density lipoprotein (LDL) in patients with cardiovascular diseases. However, statin monotherapy has disadvantages attributable to myopathies and to the insufficient cholesterol reduction observed in some patients. There is a need for new well-tolerated therapies for lowering LDL. This review will focus on bempedoic acid in combination with traditional statin therapy or other lipid-lowering agents and its emerging role in LDL-C lowering. Bempedoic acid is also a viable alternative for reducing LDL cholesterol in the treatment of some patients suffering from heterozygous familial hypercholesterolemia.
The clinical significance of small, dense low-density lipoproteins
2006
Peak size of low-density lipoproteins (LDL) in humans does not show a normal, but a bimodal distribution and can be separated into two phenotypes, that differ in size, density, physicochemical composition, metabolic behavior, and atherogenicity. These phenotypes have been assigned as pattern A when larger, more buoyant LDL and pattern B when smaller, more dense LDL predominate. Small dense LDL correlates negatively with plasma HDL levels and positively with plasma triglyceride concentrations and is associated with the metabolic syndrome and increased risk for cardiovascular disease. LDL size seems to be an important predictor of cardiovascular events and progression of coronary heart diseas…
The experimental antiphospholipid syndrome: an invaluable tool to study autoimmunity-induced neurodegeneration
2014
cells and its activation inhibits their differentiation and remyelination. These suggest a possible role of CNS TLR2 in progressive autoimmune demyelination. Methods: We examined the effects of intra-cerebro-ventricular (ICV) injection of Zymozan, a TLR2 agonist, on the clinical and pathological course of EAE. The survival and clinical scores were monitored; demyelination and axonal loss were quantified by gold-black and Bielschowsky stains, and the nature of neuro-inflammatory response was characterized by TLR2, IBA-1 and CD3 stainings and PCR for immune cytokines. Immune cells were isolated from EAE brain tissue and their proliferative response to the autoantigen (PLP peptide) or Concaval…
AB1035 INTESTINAL MICROBIOTA COMPOSITION OF ADULT PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER AND HEALTHY CONTROLS (THE RHEUMA-BIOTA STUDY)
2020
Background:Although Familial Mediterranean Fever (FMF) is a monogenic disease, microbiota composition may play role in the pathogenesis or phenotypic expression.Objectives:We aim to evaluate the intestinal microbiota composition in patients with FMF and to compare with healthy controls.Methods:In this prospective cohort study, a group of 10 adult patients with FMF and 10 age-appropriate healthy controls, for which there was strict inclusion/exclusion, were enrolled. Fecal samples were stored at -80°C until DNA extraction. A region of the 16S rRNA gene (V3-V4) was selected and sequencing was performed on the Illumina MiSeq platform at the Sequencing and Bioinformatics Service of FISABIO foun…
Caracterización clínica, genética y de neuroimagen de una serie de pacientes con Esclerosis Lateral Amiotrófica
2018
Introducción La esclerosis lateral amiotrófica (ELA) es una enfermedad muy heterogénea clínicamente lo que resulta en un importante retraso diagnóstico y en último término en la ausencia de tratamientos eficaces. El objetivo de la presente tesis es la caracterización clínico-genética de una cohorte de pacientes de ELA, así como evaluar la contribución de los biomarcadores de imagen en el diagnóstico, seguimiento y pronóstico de estos pacientes considerando su fenotipo y la presencia o no de mutaciones causales. Metodología Entre enero 2014 y diciembre de 2017 se reclutaron 261 pacientes de ELA (incluyendo pacientes con atrofia muscular progresiva y esclerosis lateral primaria), 45 controles…
Plazmas miRNS kā multiplās sklerozes biomarķieri
2018
Vairākos pētījumos ir atklātas miRNS, tajā skaitā cirkulējošas miRNS, kuru daudzums ir izmainīts multiplā sklerozē. miRNS kā jaunu biomarķieru izpēte šai slimībai varētu palīdzēt diagnosticēt un prognozēt tās attīstību agrīnā stadijā. Šajā pētījumā ir prezentēti mūsu dati par dažām miRNS, kas tikadetektētas MS pacientu asins plazmā, kā izmainītas. Mēs salīdzinājām miRNS ekspresijas līmeņus MS un tās apakštipos ar veselo kontroli, lai atrastu potenciālās miRNS, kas var tikt izmantotas, kā MS biomarķieri. Galvenais mērķis bija validēt sekvenēšanas rezultātā atlasītās miRNS, kuru daudzums bija izmainīts MS pacientu asins plazmā neatkarīgā pacientu kopā. miRNS 484, kuras daudzums bija visvairāk…
DC specific Smad7 deficiency promotes differentiation of tolerogenic DCs able to attenuate EAE
2014
The immune network is a complex system for host defenses comprising various types of inflammatory and regulatory cells. Autoimmune diseases occur because of dysregulation in homeostasis caused by imbalance of these cells. The pattern of imbalance depends on the disease. Most autoimmune diseases are chronic, and the mechanism underlying this chronic nature is yet to be determined. Monoclonal antibody therapy is highly specific to the molecules targeted and is therefore highly effective. However, this therapy cannot be applied to all autoimmune diseases, and even the most effective therapy is incapable of completely inhibiting disease activity. Antigen-specific therapies have the ability to i…
Lipid-Mediated Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample
2018
Abstract Background: Tissue factor pathway inhibitor (TFPI), a Kunitz-type serine protease, is a potent anticoagulant protein in the extrinsic coagulation pathway and acts by inhibiting both the FXa and the Tissue Factor-FVIIa complex. In contrast to total and free TFPI antigen levels, the reference values and clinical determinants of total TFPI activity have not yet been studied in detail in the general population. In the present study, we aim to identify the cardiovascular determinants for total TFPI activity and investigate its association with cardiovascular disease (CVD) and total mortality, in a population at large. Methods: For this study, the first 4779 subjects of the population-ba…