Search results for "Screen"
showing 10 items of 1374 documents
Evaluation of the environmental fate and ecotoxicological impact of the pesticide chlorpyrifos in soil for improvement of its environmental risk asse…
2016
EABIOMEUBINRA; Pesticides protect crops from various pests but can also harm nontarget organisms. To minimize risks for the environment and human health, a huge amount of studies are carried out and evaluated during the authorization process of each pesticide. However, the prediction of the environmental fate and ecotoxicological impact of a pesticide remains difficult. Several 100 formerly used pesticides are now banned because unexpected risks emerged decades after their authorization. Risk assessment documents of the organophosphate insecticide chlorpyrifos (CHL) particularly lack information about its degradation and potential transformation products in soil, and its impact on non-targe…
Tecnotest: desarrollo de una herramienta de screening para la detección de adicciones tecnológicas y al juego
2019
Las Tecnologías de la Información y la Comunicación (TIC) se relacionan con las adicciones en la medida en que sus características estructurales y las condiciones de consumo como parte de la vida diaria incitan a un uso excesivo. A medida que se avanza en el desarrollo de las TIC y se induce a la conexión permanente hay un mayor número de personas con problemas similares a los que provocan los trastornos adictivos por consumo de sustancias. Al mismo tiempo, la tecnología puede exacerbar otras adicciones como es el caso del trastorno de juego a través de las modalidades de juego online cuyas variables estructurales y ambientales favorecen aún más el juego excesivo y la adicción. Por estos mo…
Detección precoz de la hipoacusia, influencia en el diagnóstico y en el tratamiento temprano
2021
Detección precoz de la hipoacusia, influencia en el diagnóstico y en el tratamiento temprano. INTRODUCCIÓN: La hipoacusia es el déficit sensorial mas frecuente en los países desarrollados. La prevalencia de cualquier grado de hipoacusia es de un 2-3 % de la población infantil y el 80% de las mismas, está presente al nacimiento. Los programa de screening auditivo (SA) se justifican por la alta incidencia de la hipoacusia y sus consecuencias devastadoras para el lenguaje cuando no se detecta precozmente. OBJETIVO: Establecer el número de niños diagnosticados de hipoacusia congénita gracias al SA en el hospital Universitario La Fe. Analizamos las técnicas utilizadas en el cribado, los parámetr…
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis
2009
The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility to motor neuron degeneration. To identify genetic variants altering risk of ALS, we undertook a two-stage genome-wide association study (GWAS): we followed our initial GWAS of 545 066 SNPs in 553 individuals with ALS and 2338 controls by testing the 7600 most associated SNPs from the first stage in three independent cohorts consisting of 2160 cases and 3008 controls. None of the SNPs selected for replication exceeded the Bonferroni threshold for significance. The two most significantly associated SNPs, rs2708909 and rs2708851 …
Qualitative screening of 116 veterinary drugs in feed by liquid chromatography-high resolution mass spectrometry: potential application to quantitati…
2014
Abstract Veterinarian and human pharmaceuticals may be intentionally added to animal feed to enhance animal production. Monitoring these substances is necessary for protecting the consumers. In this work, a screening method covering 116 human and veterinary drugs has been developed and validated in five types of animal feed at 0.02 and 0.2 mg kg−1. After a simple extraction and dilution, the samples were analysed by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS). Nearly all compounds tested were detected at 0.02 mg kg−1, based on the presence of the accurate-mass (de)protonated molecule. However, the identification using a…
Notch and Numb are required for normal migration of peripheral glia in Drosophila
2006
Abstract A prominent feature of glial cells is their ability to migrate along axons to finally wrap and insulate them. In the embryonic Drosophila PNS, most glial cells are born in the CNS and have to migrate to reach their final destinations. To understand how migration of the peripheral glia is regulated, we have conducted a genetic screen looking for mutants that disrupt the normal glial pattern. Here we present an analysis of two of these mutants: Notch and numb. Complete loss of Notch function leads to an increase in the number of glial cells. Embryos hemizygous for the weak NotchB-8X allele display an irregular migration phenotype and mutant glial cells show an increased formation of …
Revised Short Screening Version of the Profile of Mood States (POMS) From the German General Population
2021
The present study was conducted with the aim of constructing and validating a short form of the Profile of Mood States (POMS). The POMS is a widely-applied measure for the assessment of an individual's mood. Thus, it is of great relevance for many research questions in clinical and social psychology. To develop the short scale, we first examined psychometric properties and found the optimal 16-item solution among all valid combinations of the full POMS in an exploratory subsample (n = 1,029) of our complete representative sample of the German general population. We then validated this model in a confirmatory subsample (n = 977). Additionally, we examined its invariance across age groups and…
Dipeptides of S-Substituted Dehydrocysteine as Artzyme Building Blocks: Synthesis, Complexing Abilities and Antiproliferative Properties †
2021
Background: Dehydropeptides are analogs of peptides containing at least one conjugate double bond between α,β-carbon atoms. Its presence provides unique structural properties and reaction centre for chemical modification. In this study, the series of new class of dipeptides containing S-substituted dehydrocysteine with variety of heterocyclic moieties was prepared. The compounds were designed as the building blocks for the construction of artificial metalloenzymes (artzymes). Therefore, the complexing properties of representative compounds were also evaluated. Furthermore, the acknowledged biological activity of natural dehydropeptides was the reason to extend the study for antiproliferativ…
Synthesis and antiproliferative activity of the ring system [1,2]oxazolo[4,5-g]indole.
2012
Brand new ring: A series of 27 derivatives of the new ring system [1,2]oxazolo[4,5-g]indole were conveniently prepared and tested at the NCI for antiproliferative studies. Several of them showed good inhibitory activity toward all tested cell lines, reaching GI50 values generally at the micromolar and sub-micromolar levels and in some cases at nanomolar concentrations. The mean GI50 values, calculated on the full panel, were in the range 0.25-7.08 μM.
Synthesis and antiproliferative activity of [1,2,4] triazino[4,3-a]indoles
2005
A series of [1, 2, 4triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.