Search results for "Screen"

Lung tumorspheres as a drug screening platform against cancer stem cells.

2019

Treatment resistance and metastasis are linked to cancer stem cells (CSCs). This population represents a promising target, but remains unexplored in lung cancer. The main objective of this study was to characterize lung CSCs and discover new therapeutic strategies.

Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs

2012

Hepatotoxicity is a major reason for drug nonapprovals and withdrawals. The multiparametric analysis of xenobiotic toxicity at the single cells level using flow cytometry and cellular imaging-based approaches, such as high-content screening (HCS) technology, could play a key role in the detection of toxicity and the classification of compounds based on patterns of cellular injury. This study aimed to develop and validate a practical, reproducible, in vitro multiparametric cell-based protocol to assess those drugs that are potentially hepatotoxic to humans and to suggest their mechanisms of action. The assay was applied to HepG2 human cell line cultured in 96-well plates and exposed to 78 di…

Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells

2012

PLoS one 7(7), e40853 (2012). doi:10.1371/journal.pone.0040853

Deep neural networks leveraging different arrangements of molecular fingerprints to define a novel embedding for virtual screening procedure

2022

A proposal for an evidence-based model of the screening for the colorectal carcinoma in an Italian setting

2011

Introduction. The aim of this paper is to improve the feasibility perception of policymakers, health care workers and target population about the cost-effectiveness of the implementation of colorectal screening as Public Health strategy. Methods. Retrospective study by application of a three-step model designed for a local setting in Sicily (Palermo and its Province) in order to distribute Fecal Occult Blood Tests (FOBTs), offer colonoscopy and surgery, by district allocation of pharmacies, public digestive endoscopic centres and oncologic and general surgery units. Mean adherence to consolidated colorectal screening programs in Italy was applied in order to evaluate the feasibility of an o…

The role of «perceived loss» aversion on credit screening: an experiment

2013

A major characteristic of credit markets is information asymmetry.To combat its problems, as credit rationing, principals can use a menu of contracts to screen clients with different risk level. We conduct a laboratory experiment to address an important question for such settings —does the framing of the offered menu of contracts interfere with the self-selection mechanism? The answer is yes. We find subjects' choices shift when the same (positive) outcomes of the same menu of contracts are presented in two different frames. Subjects exhibit loss aversion in their perception of the positive outcomes below the reference point, and self-selection fails to occur. Uno de los mayores problemas a…

The Time Response of Glass Resistive Plate Chambers to Heavily Ionizing Particles

2007

The HARP system of resistive plate chambers (RPCs) was designed to perform particle identification by the measurement of the difference in the time-of-flight of different particles. In previous papers an apparent discrepancy was shown between the response of the RPCs to minimum ionizing pions and heavily ionizing protons. Using the kinematics of elastic scattering off a hydrogen target a controlled beam of low momentum recoil protons was directed onto the chambers. With this method the trajectory and momentum, and hence the time-of-flight of the protons can be precisely predicted without need for a measurement of momentum of the protons. It is demonstrated that the measurement of the time-o…

Paper 6: EUROCAT member registries: organization and activities.

2011

BACKGROUND: EUROCAT is a network of population-based congenital anomaly registries providing standardized epidemiologic information on congenital anomalies in Europe. There are three types of EUROCAT membership: full, associate, or affiliate. Full member registries send individual records of all congenital anomalies covered by their region. Associate members transmit aggregate case counts for each EUROCAT anomaly subgroup by year and by type of birth. This article describes the organization and activities of each of the current 29 full member and 6 associate member registries of EUROCAT. METHODS: Each registry description provides information on the history and funding of the registry, popu…

Advances in endoscopic imaging of colorectal neoplasia.

2010

Colon cancer screening is arguably the most important activity performed by gastroenterologists. Recent decreases in rates of death from colorectal cancer indicate that screening methods such as colonoscopy have a positive impact. There is still room for improvement, however, particularly in prevention of right-sided colon cancer. Practice issues, such as making colonoscopy more comfortable, safer, and less costly, are keys to continued success in cancer prevention. Colonoscopy techniques, technologies, and quality control measures have advanced to improve detection, classification, and removal of early neoplasias. In particular, slow, careful inspection of the colon by gastroenterologists …

Mitigating deficiencies of generation Z through new educational methodologies in a business statistic course

2020

[EN] Nowadays, most of the students in first course at University are from the socalled Generation Z. Since a young age, these students have been used digital technology such as internet, mobile phones, tablets and laptops developing certain skills. But a large majority of these students have some deficiencies such as low knowledge of mathematics, scarce levels of motivation, concentration or logical reasoning and little patience (they want to understand everything quickly). These characteristics must be improved being a hard work to do by teachers. New educational methodologies are being adapted taking into account these digital skills and mitigating the deficiencies observed in some stude…