Search results for "Screening method"
showing 10 items of 31 documents
Autoimmunity seen through the SEREX-scope.
2003
Autoantibodies can be detected in autoimmune diseases with a long prodromal phase and may serve as early indicators of disease activity. Autoantibody-based screening methods are therefore potent tools for the identification of target antigens. The SEREX method (serological identification of antigens by recombinant expression cloning) has been developed for the serological definition of immunogenic tumor antigens. Recent studies indicate that the SEREX approach may also be utilized for the analysis of complex immune responses involved in autoimmune diseases.
Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors.
2011
Reliable and effective virtual high-throughput screening (vHTS) methods are desperately needed to minimize the expenses involved in drug discovery projects. Here, we present an improvement to the negative image-based (NIB) screening: the shape, the electrostatics, and the solvation state of the target protein’s ligand-binding site are included into the vHTS. Additionally, the initial vHTS results are postprocessed with molecular mechanics/generalized Born surface area (MMGBSA) calculations to estimate the favorability of ligand-protein interactions. The results show that docking produces very good early enrichment for phosphodiesterase-5 (PDE-5); however, in general, the NIB and the ligand-…
Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project.
2010
The 6th European Framework Programme project LIINTOP was specifically raised to optimise and provide established protocols and experimental in vitro models for testing intestinal and liver absorption, metabolism and toxicity of molecules of pharmacological interest. It has been focused on some of the most promising existing liver and intestine in vitro models with the aim of further improving their performance and thus taking them to a pre-normative research stage. Regarding the specific area of the liver, a first basic approach was the optimisation of in vitro hepatic models and the development and optimisation of in vitro approaches for toxicity screening. New advanced technologies have b…
SCREENING OF CHEMICAL SPILL RISKS TO MUNICIPAL SEWAGE TREA TMENT PLANTS
1994
Seven operational mishaps were specified on the basis of a questionnaire on wastewater treatment plants, some of them large. In this study a process was developed for screening the chemical spill risks to municipal biological sewage treatment plant. Data on wastewater treatment processes, potential spill sources and chemical properties were combined to determine the threshold chemical quantities which may inhibit the removal of carbonaceous material, prevent nitrification and methanogenesis, cause sludge contamination or lead to the aeration capacity being exceeded. Two sewage treatment plants and eleven industrial sites were chosen for field studies. The influence of spill duration and mai…
Application of the Morris method for screening the influential parameters of fuzzy controllers applied to wastewater treatment plants
2011
In this paper,we evaluate the application of a sensitivity analysis to help fine-tuning a fuzzy controller for a biological nitrogen and phosphorus removal (BNPR) plant. TheMorris Screeningmethod is proposed and evaluated as a prior step to obtain the parameter significance ranking. First, an iterative procedure has been performed in order to find out the proper repetition number of the elementary effects (r) of the method. The optimal repetition number found in this study (r = 60) is in direct contrast to previous applications of the Morris method, which usually use low repetition number, e.g. r = 10 ~ 20. Working with a non-proper repetition number (r) could lead to Type I error (identify…
Applications of the Alcohol Use Disorders Identification Test (AUDIT) in Distinct Health Areas
2019
Abstract This chapter provides an updated vision of the contexts in which the psychometric viability of the AUDIT has been evaluated during this century. This has permitted the identification of why, where, and how this screening method, as well as its most well-known abridged version (the AUDIT-C), is being used in different socio-sanitary areas. Throughout the chapter, appropriate recommendations are offered for all professionals wishing to use these instruments, while also pointing out potential future research lines.
The Inclusion of Socially Irresponsible Companies in Sustainable Stock Indices
2019
Social rating agencies implement complex filters to identify the companies with the best sustainable and social performance and help investors select the companies for their sustainable portfolios. This study analysed whether companies that are defined as ethical, sustainable and socially responsible by those agencies actually deserve this label. More specifically, the inclusion in the prestigious Dow Jones Sustainability Index (DJSI) World of companies that have been involved in controversies according to the Thomson Reuters Eikon database was studied. The results show that the inclusion of irresponsible companies in the DJSI Index is a fact. This outcome is in line with previous studies t…
Untersuchungen zur Zeitstruktur pathologischer Sprachproduktion
1996
Ein einfaches Screening-Verfahren wird vorgestellt, mit dessen Hilfe es moglichist, Sprechstorungen zu bewerten. Mittels eines Algorithmus werden die digitalisierten Sprechsignale zeitnormiert und wir
How does early developmental assessment predict academic and attentional-behavioural skills at group and individual levels?
2009
The main aim of the study was to explore the ability of a brief developmental assessment to predict teacher-rated learning and attentional and behavioural skills in the first grade of school at both the group and individual levels. A sample of 394 children (181 males, 213 females) aged 4 years were followed to the age of 6 years, and 283 of the children (145 males, 138 females; mean age 7 y 11 mo) were followed further to the first grade (age 7 y) at school. The children were administered a brief but comprehensive developmental assessment (Lene - a neurodevelopmental screening method) at their local child health-care centres at ages 4 and 6 years. In the first grade, teachers completed a de…
Validation of a New Cognitive Screening Method for Stroke Patients
2019
Objective. Two million adults under fifty years of age have a cerebral stroke every year worldwide. Neuropsychological assessment is the best way to identify poststroke cognitive dysfunction, but it is often time-consuming and can be tiring for the patient, and hospitals vary in their availability of neuropsychological expertise. A valid and reliable cognitive screening method could be advantageous in identifying patients who need comprehensive neuropsychological examination. Our purpose in this study was to validate a newly developed cognitive screening method as an identifier of cognitive dysfunction after stroke in working-aged patients. Methods. We analyzed new cognitive screening metho…