Search results for "Secondary"

showing 10 items of 1765 documents

Efficacy of switching between tumor necrosis factor-alfa inhibitors in psoriasis: results from the Italian Psocare registry

2014

Background: Some studies have shown that switching patients from one tumor necrosis factor (TNF)-alfa inhibitor to another may be beneficial when they have an inadequate response or an adverse event. Objective: We sought to assess the variables predicting the efficacy of the second TNF-alfa inhibitor in patients discontinuing the first TNF-alfa inhibitor. Methods: Data from all 5423 consecutive patients starting TNF-alfa inhibitor therapy for psoriasis between September 2005 and September 2010 who were included in the Italian Psocare registry were analyzed. Results: In 105 patients who switched to a second TNF-alfa inhibitor who had complete follow-up data, 75% improvement in the Psoriasis …

Maleprimary inefficacy75% improvement in the Psoriasis Area Severity Index score; PASI; PASI 75; Psoriasis Area Severity Index; TNF; biologics; efficacy; primary inefficacy; psoriasis; secondary loss of efficacy; switching; tumor necrosis factor; tumor necrosis factor-alfa inhibitors; Adult; Analysis of Variance; Antibodies Monoclonal; Antibodies Monoclonal Humanized; Cohort Studies; Confidence Intervals; Dose-Response Relationship Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Immunoglobulin G; Italy; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Proportional Hazards Models; Psoriasis; Receptors Tumor Necrosis Factor; Registries; Retrospective Studies; Risk Assessment; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young AdultSWITHCESefficacyTNFpsoriasis; psoriasis arthritis; pharmachological treatmentPASI 75Severity of Illness IndexReceptors Tumor Necrosis FactorEtanerceptCohort StudiesMonoclonalReceptorsSettore MED/35 - Malattie Cutanee E VenereeRegistriesHumanizedtumor necrosis factor-alfa inhibitors.switchingHazard ratioAntibodies MonoclonalMiddle AgedTreatment OutcomeItalyPredictive value of tests75% improvement in the Psoriasis Area Severity Index scoreFemaleDrugPsoriasis Area Severity IndexbiologicTNF-alphaAdultmedicine.medical_specialtytumor necrosis factorDermatology75% improvement in the Psoriasis Area Severity Index score; PASI; PASI 75; Psoriasis Area Severity Index; TNF; biologics; efficacy; primary inefficacy; psoriasis; secondary loss of efficacy; switching; tumor necrosis factor; tumor necrosis factor-alfa inhibitorsAntibodies Monoclonal Humanizedsecondary loss of efficacyRisk AssessmentAntibodiestumor necrosis factor-alfa inhibitorsDrug Administration ScheduleDose-Response RelationshipYoung AdultSettore MED/35Predictive Value of TestsInternal medicinePsoriasisSeverity of illnessmedicineConfidence IntervalsHumansPsoriasisbiologicsAdverse effectPsoriasis; TNF-alphaProportional Hazards ModelsRetrospective Studiespsoriasibiologics; efficacy; primary inefficacy; psoriasis; secondary loss of efficacy; switching; tumor necrosis factor-alfa inhibitors; Adalimumab; Adult; Analysis of Variance; Antibodies Monoclonal; Antibodies Monoclonal Humanized; Cohort Studies; Confidence Intervals; Dose-Response Relationship Drug; Drug Administration Schedule; Etanercept; Female; Follow-Up Studies; Humans; Immunoglobulin G; Infliximab; Italy; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Proportional Hazards Models; Psoriasis; Receptors Tumor Necrosis Factor; Registries; Retrospective Studies; Risk Assessment; Severity of Illness Index; Treatment Outcome; Tumor Necrosis Factor-alpha; Young Adult; 2708Analysis of Variancepharmachological treatmentDose-Response Relationship DrugProportional hazards modelbusiness.industrytumor necrosis factor-alfa inhibitorTumor Necrosis Factor-alphaPASIAdalimumabRetrospective cohort studypsoriasis arthritismedicine.diseaseConfidence intervalInfliximabSurgeryImmunoglobulin GMultivariate AnalysisANTI-TNFAbusiness2708Follow-Up Studies
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Indoor air problems and the perceived social climate in schools: A multilevel structural equation analysis

2018

Indoor air problems in schools appear to influence learning outcomes and absence rates. However, previous research has not investigated whether indoor air problems influence the social climate of schools. Therefore, we studied whether indoor air problems observed in schools associate with students' perceptions of the teacher-student relationship and class spirit. The nationwide sample of Finnish schools (N = 194 schools/27153 students) was analyzed using multilevel structural equation modeling. Data on the schools' social climate collected from students were merged with independently collected data on observed indoor air problems from school principals. We found that the teacher-student rel…

Maleteacher-student relationshipClimateApplied psychologyindoor airsocial relations010501 environmental sciences01 natural sciencesalakoulusocial climateIndoor air qualitySurveys and QuestionnairesMuut yhteiskuntatieteet - Other social sciencesComputingMilieux_COMPUTERSANDEDUCATIONWaste Management and Disposalta515FinlandSchools4. Education05 social sciencesMultilevel modelpsyykkiset vaikutukset050301 educationta3142ilmapiiriair qualityPollution3142 Public health care science environmental and occupational healthsosiaaliset suhteetindoor air problemsilmanlaatukoulurakennuksetAir Pollution Indoorclass spiritFemalemultilevel analysisPsychologysosiaaliset vaikutuksetindoor air qualityEnvironmental EngineeringAdolescentKansanterveystiede ympäristö ja työterveys - Public health care science environmental and occupational healthIndoor airmonitasomallinnusschooleducationSample (statistics)psykososiaaliset tekijätAffect (psychology)Structural equation modelingsisäilmaongelmatHumansLearningEnvironmental Chemistrylower secondary schoolStudentsopettaja-oppilassuhde0105 earth and related environmental sciencessisäilmapsychosocial effectPublic OpinionkouluPerception0503 educationScience of The Total Environment
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Teacher-student interaction and lower secondary school students’ situational engagement

2018

BACKGROUND Prior research has shown that engagement plays a significant role in students' academic learning. AIMS The present study sought to expand the current understanding of students' engagement by examining how situational engagement during a particular lesson is associated with the observed teacher-student classroom interactions (i.e., emotional support, instructional support, and classroom organization) in the same lesson. SAMPLE The participants were 709 Grade 7 students (47.7% girls) from 59 classrooms in 26 lower secondary schools and 51 teachers. METHODS The data consisted of 155 video-recorded lessons (90 language arts and 65 mathematics lessons) coded using the Classroom Assess…

Maleteacher–student interactionAdolescentAcademic learningAcademic achievementluokkatyöskentelyEducationComputingMilieux_COMPUTERSANDEDUCATIONDevelopmental and Educational PsychologyMathematics educationHumans0501 psychology and cognitive sciencesInterpersonal Relationsta516situational engagementSituational ethicsStudentslower secondary schoolopettaja-oppilassuhdeta515Class (computer programming)Language artsSchools4. Education05 social sciences050301 educationSocial SupportsitoutuminenHelp-seekingEmotional engagementobservationsAdolescent BehaviorObservational studyFemaleSchool TeachersyläkouluPsychology0503 education050104 developmental & child psychologyFollow-Up StudiesBritish Journal of Educational Psychology
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Development and Validation of the Questionnaire of Academic Stress in Secondary Education: Structure, Reliability and Nomological Validity

2018

This study presents the validation process of the Questionnaire on Academic Stress in Secondary Education (QASSE) designed to assess the wide variety of school sources and situations related to academic stress in adolescence, and their relationship with students&rsquo

MalevaliditySecondary educationgender and age differencesAdolescentPsychometricsHealth Toxicology and MutagenesiseducationValidityNomological networklcsh:MedicineArticleDevelopmental psychologySurveys and QuestionnairesIntervention (counseling)Stress (linguistics)secondary educationHumans0501 psychology and cognitive sciencesChildStudentsReliability (statistics)academic stressPrincipal Component AnalysisSchoolsreliability05 social scienceslcsh:RPublic Health Environmental and Occupational HealthReproducibility of Results050301 educationpsychological and physical well-beingFemaleadolescencePsychology0503 educationStress Psychological050104 developmental & child psychologyInternational Journal of Environmental Research and Public Health
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Time-Diary Research Method: Methodological Context, Evaluation and Applications in Academic Research

2013

In this paper, we review the literature on the use of time-diary in research. The paper highlights key methodological issues of the time-diary that is among the first types of diaries used in scientific research in general and in consumer research in particular.

Management sciencePsychological researchContext evaluationKey (cryptography)Engineering ethicsConsumer researchSecondary researchInformationSystems_MISCELLANEOUSTime diaryPsychologyDiary studiesResearch methodSSRN Electronic Journal
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Manganese(iv) oxamato-catalyzed oxidation of secondary alcohols to ketones by dioxygen and pivalaldehyde

1998

A new manganese(IV) oxamato complex possessing a bis(moxo) dimanganese core has been synthesized, magnetically and structurally characterized, and found to catalyze the aerobic oxidation of secondary alcohols to ketones with cooxidation of pivalaldehyde to pivalic acid with good yields and high selectivities. Ruiz Garcia, Rafael, Rafael.Ruiz@uv.es ; Fernandez Picot, Isabel, Isabel.Fernandez@uv.es ; Pedro Llinares, Jose Ramon, Jose.R.Pedro@uv.es ; Rosello Arce, Antonio Luis, Antonio.L.Rosello@uv.es ; Castro Bleda, Isabel, Isabel.Castro@uv.es

ManganesePivalic acidDioxygenUNESCO::QUÍMICA::Química inorgánicaUNESCO::QUÍMICAMetals and Alloyschemistry.chemical_elementGeneral ChemistryManganeseKetones:QUÍMICA::Química inorgánica [UNESCO]:QUÍMICA [UNESCO]CatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsCatalysischemistry.chemical_compoundchemistryAlcoholsOxidationMaterials ChemistryCeramics and CompositesOxidation of secondary alcohols to ketonesOrganic chemistryManganese ; Oxidation ; Alcohols ; Ketones ; Dioxygen
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Seasonal variation in total phenolic content of Dictyopteris polypodioides (Dictyotaceae) and Cystoseira amentacea (Sargassaceae) from the Sicilian c…

2013

Phlorotannins are polyphenolic secondary metabolites found in almost all brown algae that function as defense against grazers, pathogens and epiphytes but are also involved in photoprotection mechanisms. These compounds, produced in the Golgi apparatus, are accumulated in cytoplasm, within vesicules called physodes, or bound to the cell wall. The concentration of phlorotannins dif-fers within and between species, shows geographical variations but may be also affected by abiotic or biotic factors. Aims of this study were to evaluate: (i) the temporal variation of total phenolic content in two brown algae, Dictyopteris polypodioides and Cystoseira amentacea, living respec-tively in the upper …

Mar MediterraneoSettore BIO/02 - Botanica SistematicaBrown algaeSettore BIO/04 - Fisiologia Vegetalesecondary metabolitephenol compound
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Five new species of Marantaceae endemic to Gabon

2012

ABSTRACT Five new species of African Marantaceae are described and illustrated from two locations in Gabon, Marantochloa alba A. C. Ley, sp. nov., M. grandiflora A. C. Ley, sp. nov., M. montsdecristalii A. C. Ley, sp. nov. and Thaumatococcus flavus A. C. Ley, sp. nov. from the mountainous area of Monts de Cristal, north east of the capital Libreville, as well as Hypselodelphys lopei A. C. Ley, sp. nov. from the central part of Gabon in secondary forest near La Lope and Mikongo. New keys to the genera Marantochloa Brongn. & Gris., Thaumatococcus Benth. and Hypselodelphys (K. Schum.) Milne.-Redh. are provided.

MarantaceaeMarantochloaLiliopsidaZingiberalesPlant ScienceNorth eastBiodiversityBiologybiology.organism_classificationThaumatococcusTracheophytaMarantaceaeHypselodelphysBotanySecondary forestPlantaeTaxonomy
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Secondary Circulation of Tropical Cyclones in Vertical Wind Shear: Lagrangian Diagnostic and Pathways of Environmental Interaction

2015

Abstract This study introduces a Lagrangian diagnostic of the secondary circulation of tropical cyclones (TCs), here defined by those trajectories that contribute to latent heat release in the region of high inertial stability of the TC core. This definition accounts for prominent asymmetries and transient flow features. Trajectories are mapped from the three-dimensional physical space to the (two dimensional) entropy–temperature space. The mass flux vector in this space subsumes the thermodynamic characteristics of the secondary circulation. The Lagrangian diagnostic is then employed to further analyze the impact of vertical wind shear on TCs in previously published idealized numerical exp…

Mass fluxAtmospheric ScienceInertial frame of referenceMeteorologyWind shearLatent heatSecondary circulationMechanicsTropical cycloneSpace (mathematics)Stability (probability)GeologyJournal of the Atmospheric Sciences
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Self-Ordering Secondary Structure of d- and l-Arginine-Derived Polyamidoamino Acids

2017

This paper reports on synthesis, acid–base properties and pH-dependent structuring in water of d-, l- and d,l-ARGO7, bioinspired polymers obtained by polyaddition of the corresponding arginine stereoisomers with N,N′-methylenebis(acrylamide). The circular dichroism spectra of d- and l-ARGO7 showed a peak at 228 nm and quickly and reversibly responded to pH changes, but were nearly unaffected by temperature, ionic strength, and denaturating agents. Theoretical modeling studies of L-ARGO7 showed that it assumed a folded structure. Intramolecular interactions led to transoid arrangements of the main chain reminiscent of the protein hairpin motif. Torsion angles showed a quite similar distribut…

Materials Chemistry2506 Metals and AlloysMaterials scienceArgininePolymers and PlasticsStereochemistry02 engineering and technologyOrganic Chemistry; Polymers and Plastics; Inorganic Chemistry; Materials Chemistry2506 Metals and Alloys010402 general chemistry01 natural sciencesSpectral lineInorganic Chemistrychemistry.chemical_compoundMaterials ChemistryProtein secondary structurechemistry.chemical_classificationOrganic ChemistryPolymer021001 nanoscience & nanotechnology0104 chemical scienceschemistryChiral polymers polyamidoamino acids interpenetrating peptides self-structured polymersIonic strengthIntramolecular forceAcrylamide0210 nano-technologySelf ordering
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