Search results for "Secretion"
showing 10 items of 764 documents
[35] Determination of oxidized glutathione in blood: High-performance liquid chromatography
1994
Publisher Summary The measurement of glutathione status is important in determining oxidative stress in tissues and biological fluids. The ratio of reduced to oxidized glutathione (GSH/GSSG) is a good indicator of the oxidative stress that may occur under physiological and pathological conditions. Changes in GSSG levels have been considered as intracellular signals able to modulate enzyme activity. Thus, it is important to have accurate methods to determine GSSG in biological fluids and in cells. In many cases, it is possible to use tissues, such as liver, muscle, or brain to determine GSH/GSSG. However, especially in human studies, samples from these tissues are not readily available; the …
Association of military training with oxidative stress and overreaching.
2011
ABSTRACT: We hypothesized that increased oxidative stress and disrupted redox balance may be predisposing factors and markers for overreaching (OR). Purpose: The study's purpose was to examine whether oxidative stress markers and antioxidant status and physical fitness are related to OR during an 8-wk military basic training (BT) period. Methods: Oxidative stress and antioxidant status were evaluated in the beginning and after 4 and 7 wk of training in 35 males (age = 19.7 ± 0.3 yr) at rest and immediately after a 45-min submaximal exercise. Physical activity (PA) was monitored by an accelerometer throughout BT. Indicators of OR were also examined. Results: From baseline to week 4, increase…
Myocardial Glutathione Alterations in Acute Coronary Occlusion in the Dog
1987
Glutathione (GSH) decreases in dog mycocardium upon acute coronary occlusion when compared with sham-operated dogs. Total glutathione content (GSHeq = GSH + ZGSSG) remains unchanged throughout the experiment (6 h after surgery) in both sham- and acute coronary occlusion-operated dogs. GSSG and GSH/GSSG ratio increases and decreases respectively in all animals but tends to reach the normal value after 6 h in sham-operated dogs. Both parameters (GSSG and GSH/GSSG ratio) remain altered in acute coronary occlusion-operated ones. This alteration of glutathione status in ischemic myocardium is discussed.
Role of ghrelin and leptin in the regulation of carbohydrate metabolism. Part II. Leptin
2012
Leptyna jest wytwarzana przez dojrzałe adipocyty. Jej ilość dodatnio koreluje z ilością tkanki tłuszczowej. Leptyna odgrywa główną rolę w utrzymywaniu masy ciała oraz homeostazy glukozy. Jest transportowana poprzez barierę krew-mózg do ośrodkowego układu nerwowego, gdzie aktywuje autonomiczny układ nerwowy wywołując uczucie sytość a hamując apetyt. Ponadto leptyna działa poprzez szlaki ośrodkowe i obwodowe, regulując m.in. syntezę insuliny przez trzustkowe komórki b. Leptyna może także bezpośrednio wpływać na metabolizm i funkcję komórek obwodowych. Stwierdzono, że może zmieniać obwodową insulino oporność, a także szlak sygnałów insuliny w różnych rodzajach komórek wrażliwych na ten hormon.…
Glucose excites hypothalamic neurons through the activation of Transient Receptor Potential Canonical (TRPC) channels
2015
International audience
Milk as an Essential Source of Iodine in Latvian Population
2017
Abstract Milk and dairy products are studied as alternative iodine sources, because salt iodisation is controversial due to high salt consumption leading to cardiovascular diseases. However, the iodine concentration in milk markedly varies. This study evaluated the iodine concentration in cow’s milk available in the Latvian market. Iodine and fat concentration was analysed with a spectrophotometer “Varian Cary 50” based ISO 2446:2008 in 20 milk samples. Data from the Central Statistical Bureau and survey among pregnant women were used to analyse milk product consumption and its impact on iodine status. Average iodine concentration in milk samples was 457.6 (179.6) μg/L, winter samples had a…
INFECTIOUS COMPLICATIONS AFTER UMBILICAL CORD-BLOOD TRANSPLANTATION FROM UNRELATED DONORS
2016
Umbilical cord-blood (UCB) is a well-recognized alternative source of stem cells for unrelated donor hematopoietic stem cell transplantation (HSCT). As compared with other stem cell sources from adult donors, it has the advantages of immediate availability of cells, absence of risk to the donor and reduced risk of graft-versus-host disease despite donor-recipient HLA disparity. However, the use of UCB is limited by the delayed post-transplant hematologic recovery due, at least in part, to the reduced number of hematopoietic cells in the graft and the delayed or incomplete immune reconstitution. As a result, severe infectious complications continue to be a leading cause of morbidity and mort…
Clusters of adolescent physical activity tracker patterns and their associations with physical activity behaviors in Finland and Ireland:cross-sectio…
2020
Background:Physical activity trackers (PATs) such as apps and wearable devices (eg, sports watches, heart rate monitors) are increasingly being used by young adolescents. Despite the potential of PATs to help monitor and improve moderate-to-vigorous physical activity (MVPA) behaviors, there is a lack of research that confirms an association between PAT ownership or use and physical activity behaviors at the population level.Objective:The purpose of this study was to examine the ownership and use of PATs in youth and their associations with physical activity behaviors, including daily MVPA, sports club membership, and active travel, in 2 nationally representative samples of young adolescent …
Differential influence of vemurafenib and dabrafenib on patient lymphocytes despite similar clinical efficacy in melanoma
2014
Background: Since the majority of melanomas eventually become resistant and progress, combining selective BRAF inhibitors (BRAFi) with immunotherapies has been proposed to achieve more durable treatment responses. Here, we explored the impact of selective BRAFi on the hosts’ immune system. Patients and methods: Clinical data, whole blood counts (WBC) and serum lactate dehydrogenase (LDH) of 277 vemurafenib- and 65 dabrafenib-treated melanoma patients were evaluated. The frequency and phenotype of lymphocyte subpopulations were determined by flow cytometry while T cell cytokine secretion was measured by multiplex assays. Results: Progression-free survival (PFS) as well as overall survival (O…
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
2001
Biochemical, epidemiological, and genetic findings demonstrate a link between cholesterol levels, processing of the amyloid precursor protein (APP), and Alzheimer's disease. In the present report, we identify the α-secretase ADAM 10 ( a d isintegrin a nd m etalloprotease) as a major target of the cholesterol effects on APP metabolism. Treatment of various peripheral and neural cell lines with either the cholesterol-extracting agent methyl-β-cyclodextrin or the hydroxymethyl glutaryl-CoA reductase inhibitor lovastatin resulted in a drastic increase of secreted α-secretase cleaved soluble APP. This strong stimulatory effect was in the range obtained with phorbol esters and was further increa…