Search results for "Sensory system"

Rapid developmental switch in the mechanisms driving early cortical columnar networks

2006

The immature cerebral cortex self-organizes into local neuronal clusters long before it is activated by patterned sensory inputs. In the cortical anlage of newborn mammals, neurons coassemble through electrical or chemical synapses either spontaneously or by activation of transmitter-gated receptors. The neuronal network and the cellular mechanisms underlying this cortical self-organization process during early development are not completely understood. Here we show in an intact in vitro preparation of the immature mouse cerebral cortex that neurons are functionally coupled in local clusters by means of propagating network oscillations in the beta frequency range. In the newborn mouse, this…

2013

Distraction of goal-oriented performance by a sudden change in the auditory environment is an everyday life experience. Different types of changes can be distracting, including a sudden onset of a transient sound and a slight deviation of otherwise regular auditory background stimulation. With regard to deviance detection, it is assumed that slight changes in a continuous sequence of auditory stimuli are detected by a predictive coding mechanisms and it has been demonstrated that this mechanism is capable of distracting ongoing task performance. In contrast, it is open whether transient detection – which does not rely on predictive coding mechanisms – can trigger behavioral distraction, too…

Analysis of tear proteins by one- and two-dimensional thin-layer iosoelectric focusing, sodium dodecyl sulfate electrophoresis and lectin blotting. D…

1998

· Background: Isoelectric focusing (IEF) of tear proteins has not yet been carried out in a satisfactory way. Two-dimensional (2D) electrophoresis, especially in the combination of IEF with SDS, is able to differentiate between proteins in detail. The purpose of this study was therefore to analyze tear proteins by 1D IEF alone and in combination with a 2D pattern, and by IEF followed by lectin staining. · Methods: Ampholines, covering a broad range from pH 3 to pH 10, were applied. After IEF, semi-dry blotting and incubation with a group II lectin and two group V lectins was performed. · Results: Tear proteins could be separated into 31 single bands. Tear-specific pre-albumin (TSPA), lactof…

Auditory Event-Related Potentials in the Study of Developmental Language-Related Disorders

1997

This article reviews recent auditory event-related potential (ERP) studies of developmental language disorder (DLD) and dyslexia/reading disorder (RD). The possibility of using ERPs in searching for precursors of these disorders in the early development of infants at risk is also discussed. Differences in exogenous/sensory ERPs at the latency range of P1 and N1-P2 components have been reported between groups with DLD and RD and control groups. Latency differences between the groups may be related to a common timing deficit suggested by some researchers to be one of the possible underlying factors both in DLD and dyslexia. N1 amplitude group differences may be partly related to arousal/atten…

Self-Reported Adjustment of Teenagers at Soccer Training Centers: The Soccer Trainee Adjustment Scale

2008

The aim of this study was to develop a questionnaire to measure adjustment of teenagers at soccer training centers, particularly newcomers. The Soccer Trainee Adjustment Scale was adapted from the Institutional Integration Scale and assesses the trainee's adjustment to operating and social activities. The scale was tested on a sample of 136 trainees from four soccer centers. Exploratory analysis indicated that the 13 items formed five factors: peer adjustment, boarding supervisor adjustment, soccer adjustment, scholastic adjustment, and boarding adjustment. These factors had internal consistency reliability ranging from .76 to .94.

24. Aminooxyacetate, an inhibitor of H2S production, potentiates lindane-induced convulsions in rats

2013

Purpose: H 2 S is a gaseous molecule recently recognized as endogenously produced neurotransmitter with different, still not well known, physiological and pathological roles. Cystathionine- β -synthase (CBS) is a major enzyme responsible for H 2 S production in the brain. The aim of this study was to investigate the effects of aminooxyacetate, potent CBS inhibitor, on convulsions induced by lindane in rats. Methods: Adult male Wistar albino rats were intraperitoneally (i.p.) treated with lindane 4 mg/kg and observed for convulsive behavioral manifestations during next 30 min. Aminooxyacetate (0.25 mmol/kg) or saline were injected 30 min prior to lindane administration. Seizure behavior was …

93. Structural brain abnormalities in attention-deficit/hyperactivity disorder: A voxel-based MRI study in adult patients

2009

Accuracy and accommodation capability of a handheld autorefractor

2000

Purpose: To determine the accuracy of measurement by the Nikon Retinomax handheld autorefractor and its ability to relax accommodation. Setting: Pediatric Section, Department of Ophthalmology, University of Mainz, Germany. Methods: To perform a series of comparative measurements, autorefractor readings were obtained on healthy young adults (students) and on children aged 2 to 12 years. The autorefractor readings were compared with subjective refractions of the young adults and with cycloplegic retinoscopy of the children. Results: In adults, the accuracy of the handheld autorefractor measurements was comparable to that of conventional tabletop autorefractors. In children, the autorefractor …

Preoperative simulation of postoperative iris-fixated phakic intraocular lens position and simulation of aging using high-resolution Scheimpflug imag…

2006

To increase postoperative safety after implantation of iris-fixated phakic intraocular lenses (pIOLs), optimal preoperative evaluation and patient selection is mandatory. We present a new software tool in a high-resolution Scheimpflug imaging device that precisely simulates the postoperative position of an iris-fixated pIOL and also simulates the effect of aging on the pIOL's position.

Mismatch negativity (MMN) as a tool for investigating auditory discrimination and sensory memory in infants and children

2000

For decades behavioral methods, such as the head-turning or sucking paradigms, have been the primary methods to investigate auditory discrimination, learning and the function of sensory memory in infancy and early childhood. During recent years, however, a new method for investigating these issues in children has emerged. This method makes use of the mismatch negativity (MMN), the brain's automatic change-detection response, which has been used intensively in both basic and clinical studies in adults for twenty years. This review demonstrates that, unlike many other components of event-related potentials, the MMN is developmentally quite stable and can be obtained even from pre-term infants…