Search results for "Shock"
showing 10 items of 1248 documents
The Chaperone System in Salivary Glands: Hsp90 Prospects for Differential Diagnosis and Treatment of Malignant Tumors
2022
Salivary gland tumors represent a serious medical problem and new tools for differential diagnosis and patient monitoring are needed. Here, we present data and discuss the potential of molecular chaperones as biomarkers and therapeutic targets, focusing on Hsp10 and Hsp90. The salivary glands are key physiological elements but, unfortunately, the information and the means available for the management of their pathologies, including cancer, are scarce. Progress in the study of carcinogenesis has occurred on various fronts lately, one of which has been the identification of the chaperone system (CS) as a physiological system with presence in all cells and tissues (including the salivary gland…
Cigarette smoke affects heat-shock proteins in human lung fibroblasts: a proteomic study and identification of three expressed HSP10 variants differe…
2006
Role of heat shock proteins in the pathogenesis of myasthenia gravis.
2010
Hsp27 and Hsp60 in human submandibular salivary gland: Quantitative patterns in healthy and cancerous tissues with potential implications for differe…
2021
Tumors of the submandibular salivary gland (SMG) are uncommon but sufficiently frequent for the physician to consider them in routine examinations and for the pathologist to be prepared to differentiate them from other tissue abnormalities. However, scarcity of specimens makes training difficult, a situation compounded by the lack of accepted universal diagnostic guidelines. Furthermore, there is little information on the chaperone system (CS) of the gland, despite the increasing evidence of its participation in carcinogenesis as a biomarker for diagnosis and patient follow up, and in the mechanisms by which the tumor cells thrive. We are investigating this aspect of various tumors, and her…
Chaperonin Hsp60 and Cancer Therapies
2020
The heat shock protein 60 (Hsp60) is a chaperonin belonging to the chaperoning (chaperone) system that typically contributes to protein homeostasis inside mitochondria, but also plays various non-canonical roles unrelated to protein quality control beyond the organelle. Chaperonopathies are disorders in which chaperones play an etiologic-pathogenic role and contribute to the onset/progression of disease. Hsp60 chaperonopathies by mistake are diseases in which the chaperonin is apparently normal (as far as it can be determined with current methodologies) but it actively contributes to pathology, for example in certain types of cancer, and autoimmune and chronic inflammatory disorders. In cer…
THE GUT-BRAIN AXIS: EFFECTS OF THE PROBIOTIC LACTOBACILLUS FERMENTUM INTRODUCED IN THE DIET OF ETHANOL-FED MICE
2022
Heat Shock Protein in embryonic and adult submandibular salivary glands in healthy and tumorigenic tissues
2020
Heat Shock Proteins (HSPs) role in development and function of human salivary glands have not yet been measured or mapped in detail, in particular, HSP60 role is unknown. They can be potential biomarkers for glandular diseases and malignancies. We present our initial findings on HSP10, HSP27, HSP60, HSP70 and HSP90 distribution in human submandibular salivary glands (SMG) at various stages of development and tumorigenesis.
Study of a Semi Active Electromagnetic Regenerative Suspension
2016
The main objective of this work is the theoretical and numerical study of a device that allows recovering energy from an automobile suspension. In place of the viscous damper, which dissipates the kinetic energy of the vehicle due to rough roads or more marked obstacles, an electromagnetic damper performs the functions of the viscous shock absorber with a recovery of electric energy. The damper has permanent magnets and its working is based on the electromagnetic induction. The used ferromagnetic material is the Supermendur, which has very good ferromagnetic properties, but is expensive and difficult to found, so that the choice of different material is useful to reduce the costs. The mathe…
Design of an Electromagnetic Regenerative Damper and Energy Harvesting Assessment
2016
Design of an electromagnetic regenerative shock absorber is proposed in this paper. In order to increase the efficiency of land vehicles the sources of energy losses have to be eliminated, or reduced. For this reason, several systems, recovering kinetic energy and converting it into electrical power, were studied and designed in the last years. This energy, converted into heat in traditional systems, is recovered to increase the autonomy of the vehicle. The proposed device is constituted by a stator part which coils are placed in an innovative disposition. The moving part is constituted by a rod made in stainless steel with alternated permanent magnets and spacers, so that the relative moti…
Influence on the Dynamic Behavior of Full Car Equipped by Magnetorheological Damper via Switch on/off and h∞ Controller
2011
This paper shows the influence on dynamic behavior of the car when it is equipped with magneto-rheological dampers controlled by a feedback. The feedback is built up in two ways; the first is implemented by a switch on/off control that is characterized by the injection of magnetic field with a constant value. It happens when a certain value of relative speed between the sprung and unsprung mass is exceeded. The second feedback is characterized by the H-infinity control which is based on the relative displacement in order to vary the magnetic field signal in a continuous manner. At the same time the H-infinity control of vehicle is maintained by taking into account the exceeding of speed sig…