Search results for "Signal"
showing 10 items of 6924 documents
Light-dependent CK2-mediated phosphorylation of centrins regulates complex formation with visual G-protein.
2008
AbstractCentrins are Ca2+-binding EF-hand proteins. All four known centrin isoforms are expressed in the ciliary apparatus of photoreceptor cells. Cen1p and Cen2p bind to the visual G-protein transducin in a strictly Ca2+-dependent way, which is thought to regulate light driven movements of transducin between photoreceptor cell compartments. These relatively slow motile processes represent a novel paradigm in light adaptation of photoreceptor cells.Here we validated specific phosphorylation as a novel regulator of centrins in photoreceptors. Centrins were differentially phosphorylated during photoreceptor dark adaptation. Inhibitor treatments revealed protein kinase CK2 as the major protein…
Classification of SD-OCT Volumes with LBP: Application to DME Detection
2015
International audience; This paper addresses the problem of automatic classification of Spectral Domain OCT (SD-OCT) data for automatic identification of patients with Diabetic Macular Edema (DME) versus normal subjects. Our method is based on Local Binary Patterns (LBP) features to describe the texture of Optical Coherence Tomography (OCT) images and we compare different LBP features extraction approaches to compute a single signature for the whole OCT volume. Experimental results with two datasets of respectively 32 and 30 OCT volumes show that regardless of using low or high level representations, features derived from LBP texture have highly discriminative power. Moreover, the experimen…
Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors.
1999
The assembly of signalling molecules into macromolecular complexes (transducisomes) provides specificity, sensitivity and speed in intracellular signalling pathways. Rod photoreceptors in the eye contain an unusual set of glutamic-acid-rich proteins (GARPs) of unknown function. GARPs exist as two soluble forms, GARP1 and GARP2, and as a large cytoplasmic domain (GARP' part) of the beta-subunit of the cyclic GMP-gated channel. Here we identify GARPs as multivalent proteins that interact with the key players of cGMP signalling, phosphodiesterase and guanylate cyclase, and with a retina-specific ATP-binding cassette transporter (ABCR), through four, short, repetitive sequences. In electron mic…
Classification of SD-OCT Volumes Using Local Binary Patterns: Experimental Validation for DME Detection
2016
International audience; This paper addresses the problem of automatic classification of Spectral Domain OCT (SD-OCT) data for automatic identification of patients with Diabetic Macular Edema (DME) versus normal subjects. Optical Coherence Tomography (OCT) has been a valuable diagnostic tool for DME, which is among the most common causes of irreversible vision loss in individuals with diabetes. Here, a classification framework with five distinctive steps is proposed and we present an extensive study of each step. Our method considers combination of various pre-processings in conjunction with Local Binary Patterns (LBP) features and different mapping strategies. Using linear and non-linear cl…
Multispectral analysis and cone signal modelling of pseudoisochromatic test plates
2013
The aim of the study is to determine the consistency of the desired colour reproduction of the stimuli using calibrated printing technology available to anyone (EpsonStylus Pro 7800 printer was). 24 colour vision assessment plates created in the University of Latvia were analysed right after their fabrication on august 2012 and after intense use for 7 months (colour vision screening on 700 people). Multispectral imagery results indicate that the alignment of the samples after seven months of use has maintained on the CIExy confusion lines of deutan deficiency type, but the shift towards achromatic area in the diagram indicate decrease in the total colour difference (ΔE*ab) of test backgroun…
The mechanisms of the action of omega-3s in the retina
2013
Age-related Macular Degeneration (AMD) is the leading cause of visual loss in Western countries after the age of 50y. Based on large-scale epidemiologic studies, it appears now as evident that omega-3 polyunsaturated fatty acids (PUFAs) provide benefits in preventing both, early and late stages of AMD. The aim of this paper is to summarize the knowledge about the biological mechanisms by which omega-3 PUFAs may be protective for the retina. The content of this presentation will range from biochemical data about the occurrence of omega-3 PUFAs in retinal cell membranes to results from cellular and animal studies showing that omega-3 PUFAs can influence processes involved in signal transducti…
Modern Multispectral Sensors Help Track Explosive Eruptions
2013
Due to its massive air traffic impact, the 2010 eruption of Eyjafjallajokull was felt by millions of people and cost airlines more than U.S. $1.7 billion. The event has, thus, become widely cited in renewed efforts to improve real-time tracking of volcanic plumes, as witnessed by special sections published last year in Journal of Geophysical Research, (117, issues D20 and B9).
Acoustic detection of neutrinos in bedrock
2019
We propose to utilize bedrock as a medium for acoustic detection of particle showers following interactions of ultra-high energy neutrinos. With the density of rock three-times larger and the speed of sound four-times larger compared to water, the amplitude of the generated bipolar pressure pulse in rock should be larger by an order of magnitude. Our preliminary simulations confirm that prediction. Higher density of rock also guarantees higher interaction rate for neutrinos. A noticeably longer attenuation length in rock reduces signal dissipation. The Pyh\"asalmi mine has a unique infrastructure and rock conditions to test this idea and, if successful, extend it to a full-size experiment.
Sound Event Envelope Estimation in Polyphonic Mixtures
2019
Sound event detection is the task of identifying automatically the presence and temporal boundaries of sound events within an input audio stream. In the last years, deep learning methods have established themselves as the state-of-the-art approach for the task, using binary indicators during training to denote whether an event is active or inactive. However, such binary activity indicators do not fully describe the events, and estimating the envelope of the sounds could provide more precise modeling of their activity. This paper proposes to estimate the amplitude envelopes of target sound event classes in polyphonic mixtures. For training, we use the amplitude envelopes of the target sounds…
A Simulation Analysis for Assessing the Reliability of AC/DC Hybrid Microgrids - Part II: Port Area and Residential Area
2021
This paper reports the second part of a simulation study with the aim of evaluating the ability of two portions of a hybrid AC/DC MV/LV network in maintaining their operation in off-grid mode during the loss of the main AC grid due to a failure. In particular, this paper follows a dual purpose: first, it analysis two microgrids in a residential area and a port zone capability of operating in islanded mode, applying a probabilistic approach, while there is different energy use cases, and second is to evaluate some reliability indicators.