Search results for "Silo"
showing 10 items of 412 documents
Lack of Functional Trehalase Activity in Candida parapsilosis Increases Susceptibility to Itraconazole
2022
Central metabolic pathways may play a major role in the virulence of pathogenic fungi. Here, we have investigated the susceptibility of a Candida parapsilosis mutant deficient in trehalase activity (atc1Δ/ntc1Δ strain) to the azolic compounds Fluconazole and Itraconazole. A time-course exposure to Itraconazole but not Fluconazole induced a significant degree of cell-killing in mutant cells compared to the parental strain. Flow cytometry determinations indicated that Itraconazole was able to induce a marked production of endogenous ROS together with a simultaneous increase in membrane potential, these effects being irrelevant after Fluconazole addition. Furthermore, only …
Characterization of the Differential Pathogenicity of Candida auris in a Galleria mellonella Infection Model
2021
ABSTRACT Candida auris is an emergent multidrug-resistant fungal pathogen considered a severe global threat due to its capacity to cause nosocomial outbreaks and deep-seated infections with high transmissibility and mortality. However, evidence on its pathogenicity and the complex host-pathogen interactions is still limited. This study used the in vivo invertebrate model in Galleria mellonella to assess its virulence, exploring the mortality kinetics, melanization response, and morphological changes after fungal infection compared to Candida albicans and Candida parapsilosis, with known high and low pathogenicity, respectively. All C. auris isolates presented less virulence than C. albicans…
Molecular characterization of Italian Candida parapsilosis isolates reveals the cryptic presence of the newly described species Candida orthopsilosis…
2012
The authors report the molecular characterization of Candida parapsilosis isolates recovered from the blood and venous central catheter tips of patients admitted to different care units of the Polyclinic Hospital, University of Messina, Italy. Among 97 presumed C. parapsilosis isolates examined, 94 were identified as C. parapsilosis sensu stricto and the remaining 3 isolates were found to belong to the cryptic species Candida orthopsilosis which was recovered only from blood cultures of neonates (<30 days old) born prematurely. No C. metapsilosis was found in this study. This study emphasizes the role of C. parapsilosis as an important nosocomial pathogen, and it also describes, for the fir…
Microsatellite-based genotyping of Candida parapsilosis sensu stricto isolates reveals dominance and persistence of a particular epidemiological clon…
2012
In this study, using multilocus microsatellite analysis, we report the genetic characterization of 27 Candida parapsilosis isolates recovered in two different periods of time (2007-2009 and 2011-2012) from infants hospitalized in the neonatal intensive care unit of a hospital in Messina, Italy. The results revealed the persistence and dominance of a particular infectious genotype among NICU patients and highlight the power of the used microsatellite markers in clarifying epidemiologic associations, detect micro-evolutionary variations and facilitating the recognition of outbreaks. © 2012 Elsevier B.V.
Sbarchi
2020
Fare riferimento agli sbarchi in termini di numero e di caratteristiche diviene un tema centrale per confermare o meno il possibile rischio “invasione” e per affrontare l’“emergenza immigrazione”. Questa tematica è passata nel corso degli anni da una fase emergenziale a una fase di assuefazione determinata dalle numerose informazioni sui migranti provenienti da diverse parti del mondo e nello specifico, dal Mar Mediterraneo. Gli sbarchi non possono essere ridotti esclusivamente agli “arrivi”, ma devono essere letti e inquadrati in una cornice più ampia che tenga in considerazione anche la diffusione di altri aspetti come la storia individuale, i per- corsi, i progetti e le visioni personali…
PREFAZIONE
2010
I fuggiaschi dalla miseria e dall’oppressione trovano sempre più sul loro accidentato e doloroso cammino, governi non disposti ad accogliere anche i richiedenti asilo per motivi politici, disattendendo le convenzioni internazionali e la Carta dei Diritti dell’Uomo. L'aumento dei richiedenti asilo rappresenta il fenomeno più rilevante con il quale dovremo fare i conti in questo secolo.
Zvaigžņotā Debess: 2010, Vasara (208)
2010
Contents: N.Cimahoviča. Sun’s Researcher in the Far East ; A.Balklavs. A New Hypothesis on Formation of Galaxies ; A.Balklavs. Gravitation and Peculiar Galaxies ; A.Barzdis. First Population Stars and Galaxies ; Z.Alksne, A.Alksnis. Does Giant Planet Orbit Dwarf Star? ; A.Alksnis, Z.Alksne. Epsilon Aurigae Eclipsed by Dark Dust Disk ; M.Ābele, K.Adgere, E.Grabs, L.Osipova, E.Rutkovska, J.Vjaters, V.Veckalns. Latvian Students Take Part in the Project European Student Moon Orbiter ; Announcement on the 3rd International Symposium on Dark-Sky Parks: 6-10 September 2010, Croatia ; J.Jansons. Vladimir Afanasjev – Officer of the Baikonur Cosmodrom in the 1970s ; J.Limansky. The International Year…
Gyrification from constrained cortical expansion
2014
The exterior of the mammalian brain - the cerebral cortex - has a conserved layered structure whose thickness varies little across species. However, selection pressures over evolutionary time scales have led to cortices that have a large surface area to volume ratio in some organisms, with the result that the brain is strongly convoluted into sulci and gyri. Here we show that the gyrification can arise as a nonlinear consequence of a simple mechanical instability driven by tangential expansion of the gray matter constrained by the white matter. A physical mimic of the process using a layered swelling gel captures the essence of the mechanism, and numerical simulations of the brain treated a…
Experimental and Theoretical Studies on Magnetic Exchange in Silole-Bridged Diradicals.
2006
International audience; Five bis(tert-butylnitroxide) diradicals connected by a silole [2,5-R2-3,4-diphenylsilole; R = Me3CN(®O.bul.)Z; Z = p-C6H4 (7a), p-C6H4C6H4-p (7b), 1,4-naphthalenediyl (7c), m-C6H4 (7d)] or a thiophene [2,5-R2-thiophene; R = p-Me3CN(®O.bul.)C6H4 (12)] ring as a coupler were studied. Compd. 12 crystallizes in the orthorhombic space group Pna21 with a 20.752(5), b 5.826(5), and c 34.309(5) .ANG.. X-ray crystal structure detn., electronic spectroscopy, variable-temp. EPR spectroscopy, SQUID measurements and DFT computations (UB3LYP/6-31+G*) were used to study the mol. conformations and electronic spin coupling in this series of mols. Whereas compds. 7b, 7c, and 7d are q…
Reduction of Polymerization Shrinkage Stress and Marginal Microleakage Using Soft-Start Polymerization
2003
Purpose: This study evaluated the influence of a soft-start light-curing exposure on polymerization shrinkage stress and marginal integrity of adhesive restorations. Materials and Methods: Six resin-based composites (Pertac II, Tetric Ceram, Definite, Surefil, Solitaire, and Visio-Molar) were adhesively bonded to a cylindrical cavity (n = 9 per material/light) in a photoelastic material. Visible light-curing was applied using either the standard polymerization mode (800 mW/cm2 exposure duration 40 s) of the curing light (Elipar TriLight, 3M ESPE) or the exponential mode from the same device (ramp-curing: 150 mW/cm2 to 800 mW/cm2 within the first 15 s of a total curing time of 40 s). Polymer…