Search results for "Silos"

Une occupation agro-pastorale de la transition Hallstatt final / La Tène ancienne aux confins de Corquilleroy et Treilles-en-Gâtinais

2020

National audience; Le site de Corquilleroy “la Grevasse”/Treilles-en-Gâtinais “le Soy ” (45) est une occupation agropastorale à cheval entre la fin du premier et le début du second âge du Fer. Une batterie de 32 silos,autour desquels se développent des ensembles architecturaux à quatre ou six poteaux, ainsi que quelques fosses éparses composent l’essentiel de l’occupation. Le mobilier découvert, principalement de la céramique et de la faune, consiste en de riches rejets domestiques provenant quasi exclusivement des comblements des structures de stockage. Le répertoire des céramiques est varié suggérant ainsi des utilisations multiples (stockage, cuisine, préparation et présentation) et la v…

Dosing of caspofungin based on a pharmacokinetic/pharmacodynamic index for the treatment of invasive fungal infections in critically ill patients on …

2017

Abstract Introduction The study objective was to evaluate the efficacy of different dosages of caspofungin in the treatment of invasive candidiasis and aspergillosis, in relation to the probability of pharmacokinetic/pharmacodynamic (PK/PD) target attainment, using modelling and Monte Carlo simulations in critically ill adult patients on continuous haemodiafiltration. Methods Critically ill adult patients on continuous venovenous haemodiafiltration treated with caspofungin were analysed. A population PK model was developed. Four caspofungin dosing regimens were simulated: the licensed regimen, 70 mg/day, 100 mg/day or 200 mg/day. A PK/PD target was defined as the ratio between the area unde…

The neolithic settlement of Limoneros (Elche, Alicante)

2020

[EN] This paper shows the results of rescue archaeology campaigns undertaken on the site of Limoneros, an open-air settlement located to the south of Elche (Alicante), in the alluvial plain of the Vinalopó river and dated on the first half of the 5th millennium cal BC. The settlement entails different negative structures, including two stretches of ditch, silos and basins, structures finally reused as a waste area. The analysis of the recovered evidences allows the characterization of the activities developed by a farming community in a territory articulated by the river Vinalopó, where other settlements dated back to the same period have been documented. Therefore, Limoneros supplies relev…

Homozygous deletion of ATC1 and NTC1 genes in Candida parapsilosis abolishes trehalase activity and affects cell growth, sugar metabolism, stress res…

2015

A double homozygous atc1Δ/atc1Δ/ntc1Δ/ntc1Δ mutant (atc1Δ/ntc1Δ KO) was constructed in the pathogen opportunistic yeast Candida parapsilosis by disruption of the two chromosomal alleles coding for NTC1 gene (encoding a neutral trehalase) in a Cpatc1Δ/atc1Δ background (atc1Δ KO strain, deficient in acid trehalase). The Cpatc1Δ/ntc1Δ KO mutant failed to counteract the inability of Cpatc1Δ cells to metabolize exogenous trehalose and showed a similar growth pattern on several monosaccharides and disaccharides. However, upon prolonged incubation in either rich medium (YPD) or nutrient-starved medium the viability of Cpatc1Δ cells exhibited a sensitive phenotype, which was augmented by further Cp…

La qualità tecnologica utile di prodotti edilizi innovativi

2014

Portal Vein Thrombosis in a Preterm Newborn with Mutation of the MTHFR and PAI-1 Genes and Sepsis by Candida parapsilosis

2016

Objective This report discusses the role of both congenital and acquired risk factors in the pathogenesis of portal vein thrombosis (PVT). Study Design We describe the clinical management and treatment of PVT in a preterm newborn with a homozygous mutation of the methylenetetrahydrofolate reductase (MTHFR) and plasminogen activator inhibitor-1 (PAI-1) genes and sepsis by Candida parapsilosis. Results Although literature data suggest a minor role of genetic factors in thrombophilia in the case of only one mutation, we hypothesize that combined thrombophilic genetic defects may have a cumulative effect and significantly increase the thrombotic risk. Conclusion It could be appropriate to incl…

Study of green Sicilian table olive fermentations through microbiological, chemical and sensory analyses.

2010

The production of five different green table olive cultivars was studied by a combined strategy consisting of chemical, microbiological and sensory analyses. Cultivable microflora of samples collected during processing was monitored by plate counts on seven synthetic culture media. In all samples Enterobacteriaceae, Pseudomonaceae, staphylococci, lactic acid bacteria and spore-forming bacteria were undetectable. Yeasts and moulds were countable from the day 42 (2 log CFU/ml) till the end of fermentation (6 log CFU/ml). The use of three different approaches for microorganism detection, including a culture-independent methodology, revealed the presence of barely three yeast species during the…

In vitro fungicidal activities of echinocandins against Candida metapsilosis, C. orthopsilosis, and C. parapsilosis evaluated by time-kill studies.

2010

ABSTRACT Anidulafungin, micafungin, and caspofungin in vitro activities against Candida metapsilosis , C. orthopsilosis , and C. parapsilosis were evaluated by MICs and time-kill methods. All echinocandins showed lower MICs (mean MICs, 0.05 to 0.71 mg/liter) and the highest killing rates (−0.06 to −0.05 CFU/ml/h) for C. metapsilosis and C. orthopsilosis rather than for C. parapsilosis (mean MICs, 0.59 to 1.68 mg/liter). Micafungin and anidulafungin killing rates were greater than those determined for caspofungin. None of the echinocandins had fungicidal activity against C. parapsilosis .

Microsatellite-based genotyping of Candida parapsilosis sensu stricto isolates reveals dominance and persistence of a particular epidemiological clon…

2012

In this study, using multilocus microsatellite analysis, we report the genetic characterization of 27 Candida parapsilosis isolates recovered in two different periods of time (2007-2009 and 2011-2012) from infants hospitalized in the neonatal intensive care unit of a hospital in Messina, Italy. The results revealed the persistence and dominance of a particular infectious genotype among NICU patients and highlight the power of the used microsatellite markers in clarifying epidemiologic associations, detect micro-evolutionary variations and facilitating the recognition of outbreaks. © 2012 Elsevier B.V.

Ecology and impact of an emerging invasive species in France: western ragweed (Ambrosia psilostachya DC.)

2015

Western ragweed (Ambrosia psilostachya DC.) is a perennial member of the Asteraceae native to North America that was introduced into France at the end of the 19th Century. Field observations have provided evidence of a recent expansion and of the emergence of dense clonal populations potentially threatening the biodiversity of certain Mediterranean sensitive or degraded habitats. This study therefore aimed to identify the habitats colonized and the ecological conditions favouring successful colonization by this species, and to determine its impact on the plant communities of the semi-natural habitats invaded. Ambrosia psilostachya mostly colonizes ruderal (61 %) and cultivated (14 %) enviro…