Search results for "Simulation."

Network reconstruction for trans acting genetic loci using multi-omics data and prior information.

2022

Background: Molecular measurements of the genome, the transcriptome, and the epigenome, often termed multi-omics data, provide an in-depth view on biological systems and their integration is crucial for gaining insights in complex regulatory processes. These data can be used to explain disease related genetic variants by linking them to intermediate molecular traits (quantitative trait loci, QTL). Molecular networks regulating cellular processes leave footprints in QTL results as so-called trans-QTL hotspots. Reconstructing these networks is a complex endeavor and use of biological prior information can improve network inference. However, previous efforts were limited in the types of priors…

MDA: a MATLAB-based program for morphospace-disparity analysis

2003

A MATLAB® program that examines patterns of state-space occupation is described. Four subroutines are available with which to visualize morphospace patterns: (i) in terms of their features such as dispersion, aggregation and location, thereby allowing users to extract complementary quantitative information about how the state-space is structured, and (ii) in terms of changes in those patterns that can be compared with other biotic (e.g., extinction, origination rates) or abiotic (e.g., environmental proxy) information. The program incorporates many of the latest and most widely used statistical parameters for describing multivariate spaces. The parameters are estimated on the basis of boots…

Toward fast and accurate emergency cases detection in BSNs

2020

International audience; In body sensor networks (BSNs), medical sensors capture physiological data from the human body and send them to the coordinator who act as a gateway to health care. The main aim of BSNs is to save peoples' lives. Therefore, fast and correct detection of emergencies while maintaining low-energy consumption of sensors is essential requirement of BSNs. In this study, the authors propose a new adaptive data sampling approach, where the sampling ratio is adapted based on the sensed data variation. The idea is to use the modified version of the cumulative sum (CUSUM) algorithm (modified CUSUM) that they previously proposed for wireless sensor networks to monitor the data v…

Local dimensionality reduction and supervised learning within natural clusters for biomedical data analysis

2006

Inductive learning systems were successfully applied in a number of medical domains. Nevertheless, the effective use of these systems often requires data preprocessing before applying a learning algorithm. This is especially important for multidimensional heterogeneous data presented by a large number of features of different types. Dimensionality reduction (DR) is one commonly applied approach. The goal of this paper is to study the impact of natural clustering--clustering according to expert domain knowledge--on DR for supervised learning (SL) in the area of antibiotic resistance. We compare several data-mining strategies that apply DR by means of feature extraction or feature selection w…

Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons.

2021

The impact of GABAergic transmission on neuronal excitability depends on the Cl--gradient across membranes. However, the Cl--fluxes through GABAA receptors alter the intracellular Cl- concentration ([Cl-]i) and in turn attenuate GABAergic responses, a process termed ionic plasticity. Recently it has been shown that coincident glutamatergic inputs significantly affect ionic plasticity. Yet how the [Cl-]i changes depend on the properties of glutamatergic inputs and their spatiotemporal relation to GABAergic stimuli is unknown. To investigate this issue, we used compartmental biophysical models of Cl- dynamics simulating either a simple ball-and-stick topology or a reconstructed CA3 neuron. Th…

Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors

2009

Inhibiting a protein that regulates multiple signal transduction pathways in cancer cells is an attractive goal for cancer therapy. Heat shock protein 90 (Hsp90) is one of the most promising molecular targets for such an approach. In fact, Hsp90 is a ubiquitous molecular chaperone protein that is involved in folding, activating and assembling of many key mediators of signal transduction, cellular growth, differentiation, stress-response and apoptothic pathways. With the aim to analyze which molecular descriptors have the higher importance in the binding interactions of these classes, we first performed molecular docking experiments on the 187 Hsp90 inhibitors included in the BindingDB, a pu…

Monitoring of surface velocity of hyper-concentrated flow in a laboratory flume by means of fully-digital PIV

2016

This paper investigates the utility and the efficiency of the digital image-technique for remote monitoring of surface velocity in hyper-concentrated flow by the aid of data collected during experiments conducted in the laboratory flume. In particular the present paper attention is focused on the estimation procedure of the velocity vectors and on their sensitivity with parameters (number of images, spatial resolution of interrogation area, ) of the images processing procedure.

PROPAGATION OF HYPERCONCENTRATED FLOWS IN PROTECTION CHANNELS AROUND URBAN AREAS: EXPERIMENTAL INVESTIGATION

2014

Building energy demand assessment through heating degree days: the importance of a climatic dataset

2019

Abstract The weather is one of the main factors to consider when designing a building because it represents the most important boundary condition to affect the dynamic behaviour of the building. In the literature, many studies use the degree day to predict building energy demand. However, linking the results obtained from a generic building simulation tool with defined degree days, will not give reliable energy evaluation. The goal of this study is to demonstrate that the assessment of building energy demand through the use of the degree day is correct only if the determination of the climate index is a function of the same weather data. The relationship between Heating Degree-Day and heati…

Building energy performance forecasting: A multiple linear regression approach

2019

Abstract Different ways to evaluate the building energy balance can be found in literature, including comprehensive techniques, statistical and machine-learning methods and hybrid approaches. The identification of the most suitable approach is important to accelerate the preliminary energy assessment. In the first category, several numerical methods have been developed and implemented in specialised software using different mathematical languages. However, these tools require an expert user and a model calibration. The authors, in order to overcome these limitations, have developed an alternative, reliable linear regression model to determine building energy needs. Starting from a detailed …