Search results for "Simulation."

An empirically grounded agent based model for modeling directs, conflict detection and resolution operations in air traffic management

2017

We present an agent based model of the Air Traffic Management socio-technical complex system that aims at modeling the interactions between aircrafts and air traffic controllers at a tactical level. The core of the model is given by the conflict detection and resolution module and by the directs module. Directs are flight shortcuts that are given by air controllers to speed up the passage of an aircraft within a certain airspace and therefore to facilitate airline operations. Conflicts resolution between flight trajectories can arise during the en-route phase of each flight due to both not detailed flight trajectory planning or unforeseen events that perturb the planned flight plan. Our mod…

Modelling of a prosumer’s substation in a district heating network: validation and dynamic analysis

Thermal grids will play a key role in the development of local energy communities and the achievement of 100% renewable societies. However, challenges are related to the capability of dealing with the increasing number of producers which could supply heat to thermal grids. Indeed, as in the case of the electricity grid, heat could be available for some hours in a day from RES plants installed at user level and distributed in the network (also referred to as “prosumers”). To achieve more reliable results when performing energy analyses of these innovative applications, there is a need to rely on accurate models of each component. For instance, substations are of paramount importance in the i…

Distribution of Pholeter gastrophilus (Digenea) within the stomach of four odontocete species: the role of the diet and digestive physiology of hosts

2005

We compared the distribution of the digenean Pholeter gastrophilus in the stomach of 27 harbour porpoises, Phocoena phocoena, 27 striped dolphins, Stenella coeruleoalba, 18 bottlenose dolphins, Tursiops truncatus, and 100 long-finned pilot whales, Globicephala melas. The stomach of these species is composed of 4 chambers of different size, structure and function. In all species, P. gastrophilus was largely restricted to the glandular region of the stomach, but the parasite tended to favour the fundic chamber in bottlenose dolphins and harbour porpoises, the pyloric chamber in pilot whales, and none in striped dolphins. However, predictability at infrapopulation level was generally low, sugg…

Domain specific simulation language for IT risk assessment

2011

Information technology systems represent the backbone of a company's operational infrastructure. A company's top management typically ensures that computer software and hardware mechanisms are adequate, functional and in adherence with regulatory guidelines and industry practices. Nowadays, due to depressed economic and increased intensity of performed operations, business highly recognizes the influence of effective Information Technology risk management on profitability. Design of Unified Modelling Language (UML) based Domain Specific language (DSL) described in this paper achieves synergy from in IT industry widely used UML modelling technique and the domain specific risk management exte…

The red tooth hypothesis: A computational model of predator-prey relations, protean escape behavior and sexual reproduction

2009

This paper presents an extension of the Red Queen Hypothesis (hereafter, RQH) that we call the Red Tooth Hypothesis (RTH). This hypothesis suggests that predator-prey relations may play a role in the maintenance of sexual reproduction in many higher animals. RTH is based on an interaction between learning on the part of predators and evolution on the part of prey. We present a simple predator-prey computer simulation that illustrates the effects of this interaction. This simulation suggests that the optimal escape strategy from the prey's standpoint would be to have a small number of highly reflexive, largely innate (and, therefore, very fast) escape patterns, but that would also be unlearn…

Estimation of statistical time-to-cure in cancer patients

2019

Three million people are living in France with a personal past of cancer and undergo difficulties in accessing loans and insurance. Since 2016, the French law « modernisation de notre système de santé » set the "right to be forgotten" (time beyond which insurance applicants with a past of cancer will no longer have to declare it) at 10 years after the end of treatment. From a statistical point of view, this delay can be considered as the time from which mortality due to cancer (excess mortality) disappears. After this time, the net survival curves reach a plateau corresponding to the proportion of cured patients. The verification of this hypothesis is based on two criteria: a negligible exc…

On Fuzzy Stochastic Integral Equations—A Martingale Problem Approach

2011

In the paper we consider fuzzy stochastic integral equations using the methods of stochastic inclusions. The idea is to consider an associated martingale problem and its solutions in order to obtain a solution to the fuzzy stochastic equation.

Studies on a new potential dopaminergic agent: in vitro BBB permeability, in vivo behavioural effects and molecular docking evaluation.

2015

2-Amino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-phenyl-propionamide (DA-PHEN) has been previously synthesized to obtain a potential prodrug capable of release dopamine (DA) into CNS. However, DA-PHEN could act per se as a dopaminergic drug. In this study, the permeability transport (Pe), obtained by parallel artificial permeability assay (PAMPA), indicated a low passive transcellular transport (Pe = 0.32 ± 0.01 × 10(-6 )cm/s). Using the Caco-2 cell system, the Papp AP-BL in absorptive direction (3.36 ± 0.02 × 10(-5 )cm/s) was significantly higher than the Papp BL-AP in secretive direction (1.75 ± 0.07 × 10(-5 )cm/s), suggesting a polarized transport. The efflux ratio (Papp AP-BL/Papp BL-AP = 0…

Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and Downregulation of c-Myc.

2021

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Mindfulness, inattention and performance in a driving simulator

2015

The following study will explore the link between mindfulness, driver inattention and a number of driving performance variables that were tested using the SIMUVEG driving simulator. 67 subjects between the ages of 19 and 27 completed the mindful attention awareness scale, attention-related driving errors scale and attention-related cognitive errors scale questionnaires, and were evaluated in two driving performance measures: time to line-crossing and mean speed. The results did not show a correlation between driving performance and mindfulness measures; they did show low but significant correlations with driver inattention measures. A regression analysis suggested that the specific measure …