Search results for "Simulation."
showing 10 items of 4779 documents
Cytotoxicity of the bisphenolic honokiol from Magnolia officinalis against multiple drug-resistant tumor cells as determined by pharmacogenomics and …
2014
A main problem in oncology is the development of drug-resistance. Some plant-derived lignans are established in cancer therapy, e.g. the semisynthetic epipodophyllotoxins etoposide and teniposide. Their activity is, unfortunately, hampered by the ATP-binding cassette (ABC) efflux transporter, P-glycoprotein. Here, we investigated the bisphenolic honokiol derived from Magnolia officinalis. P-glycoprotein-overexpressing CEM/ADR5000 cells were not cross-resistant to honokiol, but MDA-MB-231 BRCP cells transfected with another ABC-transporter, BCRP, revealed 3-fold resistance. Further drug resistance mechanisms analyzed study was the tumor suppressor TP53 and the epidermal growth factor recepto…
Global Linear Stability Analysis of the Flow Around a Superhydrophobic Circular Cylinder
2016
International audience; Over the last few years, superhydrophobic (SH) surfaces have been receiving an increasing attention in many scientific areas by virtue of their ability to enhance flow slip past solid walls and reduce the skin-friction drag. In the present study, a global linear-stability analysis is employed to investigate the influence of the SH-induced slip velocity on the primary instability of the 2D flow past a circular cylinder. The flow regions playing the role of 'wavemaker' are identified by considering the structural sensitivity of the unstable mode, thus highlighting the effect of slip on the global instability of the considered flow. In addition, a sensitivity analysis t…
Symbolic dynamics in a binary asteroid system
2020
We highlight the existence of a topological horseshoe arising from a a--priori stable model of the binary asteroid dynamics. The inspection is numerical and uses correctly aligned windows, as described in a recent paper by A. Gierzkiewicz and P. Zgliczy\'nski, combined with a recent analysis of an associated secular problem.
Cinema audiences reproducibly vary the chemical composition of air during films, by broadcasting scene specific emissions on breath
2016
AbstractHuman beings continuously emit chemicals into the air by breath and through the skin. In order to determine whether these emissions vary predictably in response to audiovisual stimuli, we have continuously monitored carbon dioxide and over one hundred volatile organic compounds in a cinema. It was found that many airborne chemicals in cinema air varied distinctively and reproducibly with time for a particular film, even in different screenings to different audiences. Application of scene labels and advanced data mining methods revealed that specific film events, namely “suspense” or “comedy” caused audiences to change their emission of specific chemicals. These event-type synchronou…
Realism Score for Immersive Virtual Reality Systems and Driving Simulators
2016
International audience; Traditional 2D or 3D quality assessment methods are not sufficient to assess the realism of the outputs of a simulator/immersive virtual reality system. We propose an assessment method based on a scoring system through a new approach. The objective of this paper is to propose a score scale for any simulator or immersive display system that would represent how close to the human visual system the signals that are sent through the display are. Weighted items considered are contrast, acuity, frames per seconds, brightness, field of view and the number of color available.
Shared online spreadsheets and hidden profiles: Technological effects on dyad decision strategy
2012
We report a study in which dyads use Instant Messaging to agree a preference among a set of three apartments. The information given to participants is partially overlapping, and contains a ''hidden profile'' (HP), such that a single apartment emerges as the best according to an unweighted sum of feature values only if dyad members pool information that is presented to only one of them. When dyads were additionally provided with a shared online spreadsheet, their decision strategy was more likely to be compensatory and relatively exhaustive, even if the distribution of importance among the cues in which the apartments vary meant that a ''fast and frugal'' heuristic such as take-the-best woul…
Importance of force feedback for following uneven virtual paths with a stylus
2021
It is commonly known that a physical textured path can be followed by indirect touch through a probe also in absence of vision if sufficiently informative cues are delivered by the other sensory channels, but prior research indicates that the level of performance while following a virtual path on a touchscreen depends on the type and channel such cues belong to. The re-enactment of oriented forces, as they are induced by localized obstacles in probe-based exploration, may be important to equalize the performance between physical and virtual path following. Using a stylus attached to a force-feedback arm, an uneven path marked by virtual bars was traversed while time and positions were measu…
Modelling, Identification and Control of a 5-DOF Shotcrete Robot : Development of a Framework for Automatic Application of Shotcrete for AMV 4200H
2019
Master's thesis Mechatronics MAS500 - University of Agder 2019 Today, process automation is the primary area of development in the shotcrete industry. Automaticshotcrete operations can yield an increase in operational efficiency and personnel safety as well asreductions in cost and environmental impact. This thesis develops a framework for automaticapplication of shotcrete using the AMV 4200H and provides an automatic spraying mode usinginteroceptive sensing. The shotcrete vehicle is equipped with a five degrees-of-freedom manipulatorand is currently operated manually. Our contributions include solving the forward kinematicsthrough the Denavit-Hartenberg convention, and the inverse kinemati…
Inferring intentions through state representations in cooperative human-robot environments
2014
Humans and robots working safely and seamlessly together in a cooperative environment is one of the future goals of the robotics community. When humans and robots can work together in the same space, a whole class of tasks becomes amenable to automation, ranging from collaborative assembly to parts and material handling to delivery. Proposed standards exist for collaborative human-robot safety, but they focus on limiting the approach distances and contact forces between the human and the robot. These standards focus on reactive processes based only on current sensor readings. They do not consider future states or task-relevant information. A key enabler for human-robot safety in cooperative…
Behind the Scenes of Scenario-Based Training: Understanding Scenario Design and Requirements in High-Risk and Uncertain Environments
2017
Simulation exercises as a training tool for enhancing preparedness for emergency response are widely adopted in disaster management. This paper addresses current scenario design processes, proposes an alternative approach for simulation exercises and introduces a conceptual design of an adaptive scenario generator. Our work is based on a systematic literature review and observations made during TRIPLEX-2016 exercise in Farsund, Norway. The planning process and scenario selection of simulation exercises impact directly the effectiveness of intra- and interorganizational cooperation. However, collective learning goals are rarely addressed and most simulations are focused on institution-specif…