Search results for "Simulation."
showing 10 items of 4779 documents
Integrated care pathways for airway diseases (AIRWAYS-ICPs)
2014
International audience; The objective of Integrated Care Pathways for Airway Diseases (AIRWAYS-ICPs) is to launch a collaboration to develop multi-sectoral care pathways for chronic respiratory diseases in European countries and regions. AIRWAYS-ICPs has strategic relevance to the European Union Health Strategy and will add value to existing public health knowledge by: 1) proposing a common framework of care pathways for chronic respiratory diseases, which will facilitate comparability and trans-national initiatives; 2) informing cost-effective policy development, strengthening in particular those on smoking and environmental exposure; 3) aiding risk stratification in chronic disease patien…
Exploring kainate receptor pharmacology using molecular dynamics simulations.
2010
Ionotropic glutamate receptors (iGluRs) are enticing targets for pharmaceutical research; however, the search for selective ligands is a laborious experimental process. Here we introduce a purely computational procedure as an approach to evaluate ligand–iGluR pharmacology. The ligands are docked into the closed ligand-binding domain and during the molecular dynamics (MD) simulation the bi-lobed interface either opens (partial agonist/antagonist) or stays closed (agonist) according to the properties of the ligand. The procedure is tested with closely related set of analogs of the marine toxin dysiherbaine bound to GluK1 kainate receptor. The modeling is set against the abundant binding data …
Structural Mechanism of N-Methyl-D-Aspartate Receptor Type 1 Partial Agonism
2012
N-methyl-D-aspartate (NMDA) receptors belong to a family of ionotropic glutamate receptors that contribute to the signal transmission in the central nervous system. NMDA receptors are heterotetramers that usually consist of two GluN1 and GluN2 monomers. The extracellular ligand-binding domain (LBD) of a monomer is comprised of discontinuous segments that form the functional domains D1 and D2. While the binding of a full agonist glycine to LBD of GluN1 is linked to cleft closure and subsequent ion-channel opening, partial agonists are known to activate the receptor only sub-maximally. Although the crystal structures of the LBD of related GluA2 receptor explain the mechanism for the partial a…
Trait Empathy associated with Agreeableness and rhythmic entrainment in a spontaneous movement to music task: Preliminary exploratory investigations
2017
The simulation theory of empathy suggests that we use motor processing to empathise, through modelling the actions of others. Similarly, research into embodied music cognition posits that music, particularly musical rhythm, is perceived as a motor stimulus. In both cases, the human Mirror Neuron System (MNS) is put forward as a potential underlying mechanism. If this is the case, some overlap may exist between the ability to empathise with others, and the ability to perceive rhythm in music. The present study investigated this relationship indirectly, through the study of individual differences in Trait Empathy and rhythmic entrainment. Undergraduate students ( N = 237) completed a questio…
Un outil pour les politiques scolaires: "Prospective scolaire"
2012
Today, territorial, demographic evolutions can be quick, which encourages towns to reconsider the geography of public services. This is notably the case of General Councils that handle the localisation of public middle schools and establish school sectors. Carrying out these tasks requires taking into account several parameters: demographic dynamics, urban projects, social diversity within schools, and transportation conditions. The tool 'Prospective Scolaire' integrates these multiple data in order to help communities carry out their tasks.
Effects of Air Tightness Tests on Steel Thin-Wall Box Structures with Circular and Rectangular Cross Sections
2019
In this paper, the effects of air tightness tests on steel box structures with rectangular or circular cross sections typical of port cranes (legs, arms, and crosspieces) are analyzed. Legs and arms are generally made with elements with profiles having a square or rectangular cross section, while the diagonal struts are made with profiles having circular cross sections. To verify the air tightness of these elements, a necessary requirement to protect them from corrosion if they are not protected with other protection techniques, air tightness tests are performed. These tests, in the framework of durability tests, must be carried out while maintaining the structure elasticity well below the …
Aspen Plus process-simulation model: Producing biogas from VOC emissions in an anaerobic bioscrubber
2018
A process-simulation model for a novel process consisted of an anaerobic bioscrubber was developed in Aspen Plus®. A novel approach was performed to implement the anaerobic reactor in the simulation, enabling it to be connected to the scrubber. The model was calibrated and validated using data from an industrial prototype that converted air emissions polluted with volatile organic compounds with an average daily concentration of 1129 mgC Nm−3 into bioenergy for more than one year. The scrubber, which showed a removal efficiency within 83-93%, was successfully predicted with an average absolute relative error of 5.2 ± 0.08% using an average height-to-theoretical-plate value of 1.05 ± 0.08 m …
An algebraic multigrid based shifted-Laplacian preconditioner for the Helmholtz equation
2007
A preconditioner defined by an algebraic multigrid cycle for a damped Helmholtz operator is proposed for the Helmholtz equation. This approach is well suited for acoustic scattering problems in complicated computational domains and with varying material properties. The spectral properties of the preconditioned systems and the convergence of the GMRES method are studied with linear, quadratic, and cubic finite element discretizations. Numerical experiments are performed with two-dimensional problems describing acoustic scattering in a cross-section of a car cabin and in a layered medium. Asymptotically the number of iterations grows linearly with respect to the frequency while for lower freq…
A damping preconditioner for time-harmonic wave equations in fluid and elastic material
2009
A physical damping is considered as a preconditioning technique for acoustic and elastic wave scattering. The earlier preconditioners for the Helmholtz equation are generalized for elastic materials and three-dimensional domains. An algebraic multigrid method is used in approximating the inverse of damped operators. Several numerical experiments demonstrate the behavior of the method in complicated two-dimensional and three-dimensional domains. peerReviewed
An improved algorithm for thermal dynamic simulation of walls using Z-transform coefficients
2003
The Transfer Function Method (TFM), recommended by American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE), is one of the most modern tools available to solve heat transfer problems in building envelopes and environments. TFM utilises Z-transform to solve the equations system that describes the heat transfer in a multi-layered wall. Due to an analogy with an electric circuit, it is possible to write the equations system in a matrix suitable to be solved by computer. Authors carried out an analysis on an historical building placed in the south of Italy to test the reliability and the quality of the thermal dynamic simulation using TFM. The analysis is performed usi…