Search results for "Simulations"
showing 10 items of 288 documents
Flexible power converters for the fault tolerant operation of Micro-Grids
2010
The progressive penetration level of Distributed Generation (DG) is destined to cause deep changes in the existing distribution networks no longer considered as passive terminations of the whole electrical system. A possible solution is the realization of small networks, namely the Micro-Grids, reproducing in themselves the structure of the main production and distribution of the electrical energy system. In order to gain an adequate reliability level of the microgrids the individuation and the management of the faults with the goal of maintaining the micro-grid operation (fault tolerant operation) is quite important. In the present paper flexible power converters and a companion control al…
1-D numerical simulation of sediment transport in alluvial channel beds
2011
Quantitative estimate of sediment transport processes is important especially in river-control engineering and for water management projects. In this paper the sediment routing of a 1-D model is presented and applied to some study cases. The procedure simulates the variations of bed roughness conditions due to natural sorting and to generation and migration of bed forms. The suspended-load and the bed-load are treated separatel
A paradigm of extreme rainfall pluvial floods in complex urban areas: the flood event of 15 July 2020 in Palermo (Italy)
2021
Abstract. In the last years, some regions of the Mediterranean area are witnessing a progressive increase in extreme events, such as urban and flash floods, as a response to the increasingly frequent and severe extreme rainfall events and their ground effects, which are often exacerbated by ever-growing urbanization. In such a context, the traditional defense of urban areas, which are usually based on urban drainage systems designed without regard to the impacts of urbanization and climate change on natural systems, may not be sufficient to deal with the risk deriving from the occurrence of such events. This study focuses on a very recent and particularly intense urban flood that occurred i…
Probing the physics of the solar atmosphere with the Multi-slit Solar Explorer (MUSE): I. Coronal Heating
2022
The Multi-slit Solar Explorer (MUSE) is a proposed NASA MIDEX mission, currently in Phase A, composed of a multi-slit EUV spectrograph (in three narrow spectral bands centered around 171A, 284A, and 108A) and an EUV context imager (in two narrow passbands around 195A and 304A). MUSE will provide unprecedented spectral and imaging diagnostics of the solar corona at high spatial (<0.5 arcsec), and temporal resolution (down to ~0.5s) thanks to its innovative multi-slit design. By obtaining spectra in 4 bright EUV lines (Fe IX 171A , Fe XV 284A, Fe XIX-Fe XXI 108A) covering a wide range of transition region and coronal temperatures along 37 slits simultaneously, MUSE will for the first time …
Measurement of the cosmic ray energy spectrum using hybrid events of the Pierre Auger Observatory
2012
The energy spectrum of ultra-high energy cosmic rays above 10$^{18}$ eV is measured using the hybrid events collected by the Pierre Auger Observatory between November 2005 and September 2010. The large exposure of the Observatory allows the measurement of the main features of the energy spectrum with high statistics. Full Monte Carlo simulations of the extensive air showers (based on the CORSIKA code) and of the hybrid detector response are adopted here as an independent cross check of the standard analysis (Phys. Lett. B 685, 239 (2010)). The dependence on mass composition and other systematic uncertainties are discussed in detail and, in the full Monte Carlo approach, a region of confiden…
A rule‐based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts
2019
Rule-based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from rule-based methods often does not match histological data in other areas of the heart such as the right ventricle, having a negative impact in cardiac simulations beyond the left ventricle. In this work, we present a rule-based method where fiber orientation is separately modeled in each ventricle following observations from histology. This allows to create detailed fiber orientation in specific regions such as the endocardium of the right ventricle, the inter…
Characterization of Locally Excited and Charge-Transfer States of the Anticancer Drug Lapatinib by Ultrafast Spectroscopy and Computational Studies
2020
[EN] Lapatinib (LAP) is an anticancer drug, which is metabolized to theN- and O-dealkylated products (N-LAP andO-LAP, respectively). In view of the photosensitizing potential of related drugs, a complete experimental and theoretical study has been performed on LAP,N-LAP andO-LAP, both in solution and upon complexation with human serum albumin (HSA). In organic solvents, coplanar locally excited (LE) emissive states are generated; they rapidly evolve towards twisted intramolecular charge-transfer (ICT) states. By contrast, within HSA only LE states are detected. Accordingly, femtosecond transient absorption reveals a very fast switching (ca. 2 ps) from LE (lambda(max)=550 nm) to ICT states (…
Non-syndromic Mitral Valve Dysplasia Mutation Changes the Force Resilience and Interaction of Human Filamin A
2018
International audience; Filamin A (FLNa), expressed in endocardial endothelia during fetal valve morphogenesis, is key in cardiac development. Missense mutations in FLNa cause non-syndromic mitral valve dysplasia (FLNA-MVD). Here, we aimed to reveal the currently unknown underlying molecular mechanism behind FLNA-MVD caused by the FLNa P637Q mutation. The solved crystal structure of the FLNa3-5 P637Q revealed that this mutation causes only minor structural changes close to mutation site. These changes were observed to significantly affect FLNa's ability to transmit cellular force and to interact with its binding partner. The performed steered molecular dynamics simulations showed that signi…
Protein diffusion in mammalian cell cytoplasm.
2011
We introduce a new method for mesoscopic modeling of protein diffusion in an entire cell. This method is based on the construction of a three-dimensional digital model cell from confocal microscopy data. The model cell is segmented into the cytoplasm, nucleus, plasma membrane, and nuclear envelope, in which environment protein motion is modeled by fully numerical mesoscopic methods. Finer cellular structures that cannot be resolved with the imaging technique, which significantly affect protein motion, are accounted for in this method by assigning an effective, position-dependent porosity to the cell. This porosity can also be determined by confocal microscopy using the equilibrium distribut…
Fractional calculus for the solution of non-linear stochastic oscillators with viscous dampers devices
2009
Fluid viscoelastic dampers are of great interest in different fields of engineering. Examples of their applications can be found in seismic mitigation design of structures or in vibration absorption in airplane suspension. Such devices introduce a non-linear dissipative term in the equation of motion and therefore, the solution of even a single degree of freedom system excited by a white noise process, becomes prohibitive. The solution is usually obtained by approximated methods, like the stochastic linearization technique. In this paper it is shown that, by means of fractional operators, it is possible to find the solution of oscillators provided with fluid viscoelastic devices, approachin…