Search results for "Small airways"

showing 8 items of 18 documents

Authors' response to: epithelial mesenchymal transition (EMT) in small airways of COPD patient.

2013

We understand the reservations highlighted by Sohal and Walters in their letter in response to our recent work published.1 In their letter, Sohal and Walters argue that E-cadherin and ZO-1 are absent in our immunohistochemistry analysis of small bronchi of smokers and COPD patients, and that if disappeared completely epithelium would fall apart.1 In our study, we detected downregulation of E-cadherin and ZO-1 as well as a change of intercellular and apical distribution to diffuse cytoplasmic redistribution (figure 3B; in our work published in Thorax on 7 January 2013),2 but not …

Pulmonary and Respiratory MedicineMalePathologymedicine.medical_specialtyEpithelial-Mesenchymal TransitionCopd patientsCOPD PathologyBronchiPulmonary Disease Chronic ObstructiveDownregulation and upregulationAirway EpitheliumSmokemedicineHumansEpithelial–mesenchymal transition1506COPDSmall airwaysbusiness.industrySmokingEpithelial CellsPostScriptmedicine.diseaseEpitheliumrespiratory tract diseasesmedicine.anatomical_structureRespiratory epitheliumImmunohistochemistryFemalebusinessThorax
researchProduct

Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study

2019

BACKGROUND: Small airways dysfunction (SAD) is well recognised in asthma, yet its role in the severity and control of asthma is unclear. This study aimed to assess which combination of biomarkers, physiological tests, and imaging markers best measure the presence and extent of SAD in patients with asthma.METHODS: In this baseline assessment of a multinational prospective cohort study (the Assessment of Small Airways Involvement in Asthma [ATLANTIS] study), we recruited participants with and without asthma (defined as Global Initiative for Asthma severity stages 1-5) from general practices, the databases of chest physicians, and advertisements at 29 centres across nine countries (Brazil, Chi…

Pulmonary and Respiratory MedicineSpirometrymedicine.medical_specialtySocio-culturaleSettore MED/10 - Malattie Dell'Apparato RespiratorioDISEASE03 medical and health sciences0302 clinical medicineQuality of lifeHYPERRESPONSIVENESSInternal medicineSeverity of illnessMedicine030212 general & internal medicineProspective cohort studyAsthmamedicine.diagnostic_testbusiness.industryasthmamedicine.diseaseNitrogen washoutrespiratory tract diseasessmall airways dysfunctionLUNG-MECHANICSSEVERITY030228 respiratory systemSalbutamolVENTILATION HETEROGENEITYbiomarkerAsthma; small airways dysfunctionbusinessmedicine.drugCohort study
researchProduct

Assessing and accessing the small airways; implications for asthma management

2013

Despite the wealth of experience in the management of asthma, the disease remains inadequately controlled in some patients, who face long-term respiratory impairment and disability. The disease has been characterised as an inflammatory condition affecting first the larger airways and eventually the smaller airways, but there is evidence that peripheral airway involvement defines a particular and more severe phenotype of asthma. For this reason, assessing functional and biological parameters reflective of small airways involvement is important prognostically. No assessment method is universally and directly representative of peripheral airway function, but the traditional spirometric tests, …

Pulmonary and Respiratory Medicinemedicine.medical_specialtyVital capacityVital CapacityDiseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioAsthma managementAir trappingNitric OxideNitric Oxide; Respiratory Function Tests; Vital Capacity; Humans; Tomography X-Ray Computed; Asthma; Forced Expiratory Volume; Breath TestsForced Expiratory VolumeMedicineHumansPharmacology (medical)Intensive care medicineAsthmaRespiratory Function Testbusiness.industrySmall airwaysBiochemistry (medical)medicine.diseaseResponse to treatmentAsthmarespiratory tract diseasesRespiratory Function TestsImpulse OscillometryBreath TestsAnesthesiamedicine.symptombusinessTomography X-Ray ComputedHuman
researchProduct

The potential role of SP-D as an early biomarker of severity of asthma

2021

Surfactant decreases the surface tension of peripheral airways and modulates the immunological responses of the lung. The alterations of surfactant due to the airway inflammation suggest a role in the pathogenesis of asthma. We aim to test the hypothesis that serum levels of SP-A (Surfactant Protein A) and SP-D (Surfactant Protein-D) are altered in patients with mild asthma compared to healthy controls and those alterations are related to functional abnormalities of peripheral airways, which are an early marker of progression of asthma. In this pilot study, we recruited 20 mild asthmatics and 10 healthy controls. We measured serum SP-A and SP-D and all subjects underwent clinical, lung func…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyprecision medicinePilot ProjectsSettore MED/10 - Malattie Dell'Apparato RespiratorioGastroenterologyPathogenesisPulmonary surfactantInternal medicinemedicineHumansIn patientAsthmasmall airwaysLungbusiness.industryasthmaPulmonary Surfactant-Associated Protein Dmedicine.diseaserespiratory tract diseasesPeripheralSurfactant protein Amedicine.anatomical_structureBreath TestsBiomarker (medicine)businessBiomarkersJournal of Breath Research
researchProduct

Effects on Small Airways of Two Different Combination Treatments for Asthma.

2009

business.industrySmall airwaysImmunologymedicineSmall AirwaySettore MED/10 - Malattie Dell'Apparato Respiratoriomedicine.diseasebusinessAsthmaAsthmaC73. ASSESSMENT OF AIRWAY PATHOPHYSIOLOGY
researchProduct

Glycoproteins In Large And Small Airways And In Lung Parenchyma Of COPD Patients

2011

chemistry.chemical_classificationPathologymedicine.medical_specialtyBPCOchemistrySmall airwaysbusiness.industryCopd patientsParenchymamedicineSettore MED/10 - Malattie Dell'Apparato RespiratoriobusinessGlycoprotein
researchProduct

Small airways in in sedentary and endurance-trained dystrophic (mdx) mice

2015

The effects of mild endurance exercise training on the small airways in mdx mice are unknown. We compared epithelial thickness and turnover, apoptosis, and stress marker expression in small airways of mdx mice and wild-type (WT) controls, at rest and during exercise training. Mdx and WT mice were randomly assigned to sedentary (mdx-S, n=17; WT-S, n=19) or trained (mdx-EX, n=14; WT-EX, n=16) groups. Low-intensity endurance training (running on a wheel) was done 5 d/wk for 6 wk at progressively increasing speed (rpm from 16 to 24) and time (15 min to 1 h). Lungs were processed for light microscopy and periodic acid Schiff (PAS) staining. Hsp60 and PCNA were quantified by immunohistochemistry.…

medicine.medical_specialtyTUNEL assaybiologybusiness.industrySmall airwaysAnatomyPeriodic acid–Schiff stainStainingProliferating cell nuclear antigenEndocrinologyEndurance trainingApoptosisInternal medicinebiology.proteinMedicineImmunohistochemistrybusiness4.1 Clinical respiratory physiology, exercise and functional imaging
researchProduct

Effects of endurance training on small airways of mice

2006

training small airways inflammatory cellsSettore BIO/16 - Anatomia UmanaSettore MED/10 - Malattie Dell'Apparato RespiratorioSettore BIO/09 - Fisiologia
researchProduct