Search results for "Solid"

ChemInform Abstract: The Development of Synthetic Antitumor Vaccines from Mucin Glycopeptide Antigens

2013

Synthesis of Biologically Interesting Glycopeptides.

1992

哺乳動物に見い出される大部分のタンパクは糖タンパクである。それらの糖鎖は生物学的選択性、特に膜上での認識過程に重要な働きをしている。全ての糖タンパクは糖鎖とペプチドとの間にグリコシド結合を有している。それゆえに糖ペプチドの化学合成は、立体特異的なグリコシド結合の生成と、グリコシド結合に影響を与えない選択的な保護が要求される。ベンジルグループとそれらの水素添加による脱離法は、これらの要求を満たす。しかしながら、これらの保護法を用いる方法は糖質の水酸基のブロックを必要とするので、ペプチド部分の官能基は撰択的に脱離可能でそしてベンジル基に対して orthogonal に安定なグループで保護されなければならない。この意味においてフルオレニルメトキシカルボニル (Fmoc) 基と、弱塩基、モルフォリンによる脱離と、パラジウム (0) 触媒によるアリル基転移によって脱離可能なアリルオキシカルボニル (Aloc) 基は、糖ペプチド化学においてアミノ基の保護基として有用である事が明らかにされた。同様なパラジウム (0) の化学を用いるアリルエステルと、酸により除去可能なtert-ブチルエステルはカルボキシル基の保護に有用である事が分かった。ベンジル基とアリルエステル (HYCRAM™) を用いる糖ペプチドの固相合成におけるアンカーシステムとして有効に利用される事が示された。

Some considerations in support of solid propulsion for space debris disposal.

2011

Some considerations on the use of solid rocket motors for space debris disposal are presented. From the synthesis of a de-orbit sample mission and a tradeoff study on costs and benefits, a solid propellant unit for end-of-life missions and debris in-space disposal missions is evaluated. The enhanced operation flexibility, the propellant development and an advanced ignition concept granting multiple and independent firing capability of a new solid propulsion concept are discussed.

Modeling the acid-base properties of molybdate(VI) in different ionic media, ionic strengths and temperatures, by EDH, SIT and Pitzer equations

2017

This paper reports the results of a study on the determination of the protonation constants of MoO42 −, in NaClaq, NaNO3aq, KClaq, at different ionic strengths (0 < I/mol dm− 3 ≤ 5.0 in NaClaq, 0 < I/mol dm− 3 ≤ 3.0 in NaNO3aq and KClaq) and temperatures (278.15 ≤ T/K ≤ 318.15 in NaClaq, only 298.15 K in NaNO3aq and KClaq), by potentiometric (ISE-H+ glass electrode) and spectrophotometric (UV/Vis) titrations. After a critical analysis of results and literature findings, the proposed speciation model takes into account the formation of two monomeric and four heptameric species, namely: MoO4H−, MoO4H2, (MoO4)7H86 −, (MoO4)7H95 −, (MoO4)7H104 − and (MoO4)7H113 −. Due to the complexity of…

In vitro corrosion and biocompatibility of brushite/hydroxyapatite coatings obtained by galvanic deposition on 316LSS

2018

Corrosion behavior and cytotoxicity was reported for mixed brushite (BS)/hydroxyapatite (HA) coatings deposited on 316LSS substrate through a displacement reaction. Corrosion tests, carried out in a simulated body fluid, showed that in comparison with bare 316L, coating shifts Ecorrto anodic values and reduces icorreven if oscillations were observed, which were explained in terms of the chemical interactions at the solid/liquid interface. Cell biocompatibility of the coating was investigated through osteoblastic cell line MC3T3-E1, evidencing the absence of any cytotoxicity Taken together, the results show that galvanic deposition is a simple and cost-effective method for producing bioactiv…

“Supramolecular” Solid-State Chemistry: Interpenetrating Diamond-Type Frameworks of U4+ Ions Linked byS,S′-Bidentate P2S62− Molecular Rods in UP4S12

2001

Inseparably interwoven are three independent polymeric diamond-type U(P2 S6 )2 frameworks in the structure of the title compound. The linear P2 S6 units act as molecular rods linking the pseudotetrahedral U4+ centers. U(P2 S6 )2 may be viewed as a coordination polymer which is formed from U/P/S melts by the solid-state equivalent of the self-assembly reactions in solution.

Production and properties of doped PSN electro-optical ceramics

1997

Due to multifunctionality the transparent ferroelectric ceramics is attractive to solid state chemistry and physics as a promising material for active electro-optic elements. To study doping effects on the technological processing and properties, ceramic samples of Pb1-xZxSc1/2Nb1/2O3, have been prepared, where Z: (1) Ba (0 less than or equal to x less than or equal to 1), (2) rare-earth elements: Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu (x equals 0.1), (3) PbSc1/2Nb1/2O3 doped with 5 wt.% of rare-earth oxides. Ceramic characteristics, dielectric and electro-optical parameters have been measured. Differential thermal analysis (DTA), and x-ray diffraction are used to study the infl…

ortho -Fluorination of azophenols increases the mesophase stability of photoresponsive hydrogen-bonded liquid crystals

2018

Photoresponsive liquid crystals (LCs) whose alignment can be controlled with UV-Visible light are appealing for a range of photonic applications. From the perspective of exploring the interplay between the light response and the self-assembly of the molecular components, supramolecular liquid crystals are of particular interest. They allow elaborating the structure-property relationships that govern the optical performance of LC materials by subtle variation of the chemical structures of the building blocks. Herein we present a supramolecular system comprising azophenols and stilbazoles as hydrogen-bond donors and acceptors, respectively, and show that ortho-fluorination of the azophenol dr…

Porous titania surfaces on titanium with hierarchical macro- and mesoporosities for enhancing cell adhesion, proliferation and mineralization

2014

Titanium received a macroporous titania surface layer by anodization, which contains open pores with average pore diameter around 5 μm. An additional mesoporous titania top layer following the contour of the macropores, of 100-200 nm thickness and with a pore diameter of 10nm, was formed by using the evaporation-induced self-assembly (EISA) method with titanium (IV) tetraethoxide as the precursor. A coherent laminar titania surface layer was thus obtained, creating a hierarchical macro- and mesoporous surface that was characterized by high-resolution electron microscopy. The interfacial bonding between the surface layers and the titanium matrix was characterized by the scratch test that con…

Improvement of the photo-stability of polystyrene-block-polybutadiene-block-polystyrene through carbon nanotubes

2015

Abstract The photo-stability of Polystyrene-Polybutadiene-Polystyrene (SBS) based nanocomposites containing bare multi-walled carbon nanotubes (CNTs) and carbon nanotubes bearing carboxylic functional groups (CNTs-COOH) in comparison to that of pristine SBS has been studied. The photo-oxidation of pristine SBS occurs through crosslinking reactions and oxidized species formation and both these processes begin at early stage of exposure. The formation of crosslinking, formerly in polybutadiene phase, assessed by spectroscopical (FTIR), mechanical, dynamic mechanical and rheological analysis, leads to occurrence of internal mechanical stresses in the solid state and the SBS samples become prem…