Search results for "Sonia"

Rediscovery of the allegedly “destroyed” holotype of Weltrichia fabrei Saporta, 1891 from the Rhaetian?/Hettangian of Lozère (Southern France)

2018

7 pages; International audience; A sandstone slab bearing plant macro-remains was rediscovered during recent investigations led in the buildings of the old Musée Ignon-Fabre (Mende) which were closed in 1995 and emptied in 2003. The study of the slab clearly allows it to be identified as the holotype of Weltrichia fabrei Saporta, 1891 which has been considered destroyed since the end of the 20th Century. Gaston de Saporta described this Bennettitalean fructification based on a cast and considered the type locality as Rhaetian in age. In the present paper, based on the holotype, W. fabrei was revised in order to describe and illustrate the specimen in detail. It consists of a cup with one wh…

Determination of isoniazid and pyridoxine in plasma sample of tuberculosis patients by micellar liquid chromatography

2021

It is no doubt Isoniazid is a powerful tuberculosis drug, but it might give rise to Vitamin B6 (Pyridoxine) deficiency. In this case, a usual treatment is the combined administration of Isoniazid and Pyridoxine. An easy-to-conduct procedure based on Micellar Liquid Chromatography has been developed to quantify Isoniazid and Pyridoxine in plasma from Tuberculosis patients. The sample was diluted in mobile phase, filtered and directly injected, thus avoiding extraction or purification steps. Both drugs were adequately resolved from the matrix and endogenous compounds using a mobile phase made up of 0.15 M sodium dodecyl sulfate – 8%(v/v) 1-butanol – 0.01 M phosphate buffer at pH 3, running at…

Both Short- and Long-Acting D-1/D-2 Dopamine Agonists Induce Less Dyskinesia than l-DOPA in the MPTP-Lesioned Common Marmoset (Callithrix jacchus)

2002

Abstract The current concept of dyskinesia is that pulsatile stimulation of D-1 or D-2 receptors by l -DOPA or short-acting dopamine agonists is more likely to induce dyskinesia compared to long-acting drugs producing more continuous receptor stimulation. We now investigate the ability of two mixed D-1/D-2 agonists, namely pergolide (long-acting) and apomorphine (short-acting), to induce dyskinesia in drug-naive MPTP-lesioned primates, compared to l -DOPA. Adult common marmosets ( Callithrix jacchus ) were lesioned with MPTP (2 mg/kg/day sc for 5 days) and subsequently treated with equieffective antiparkinsonian doses of l -DOPA, apomorphine, or pergolide for 28 days. l -DOPA, apomorphine, …

Discovery of a Lochkovian flora (Lower Devonian) in the Iberian Peninsula

2011

ABSTRACT The Lower Devonian represents an important episode in plant life history, which was marked by the diversification of land plants. Unfortunately, remains of early Devonian plants in the Iberian Peninsula are scarce. In the present paper, we describe a small assemblage of early land plants from the Lochkovian (Lower Devonian) of the Teruel Province in Spain. The main element consists of Taeniocrada-like sterile stems that are predominandy dichotomous and ribbon-like with a narrow central strand. An unidentified fossil formed by dichotomous axes together with an uncertain globular structure were also observed. This finding increases our knowledge of the palaeogeographical distribution…

Random cutout sets with spatially inhomogeneous intensities

2015

We study the Hausdorff dimension of Poissonian cutout sets defined via inhomogeneous intensity measures on Ahlfors-regular metric spaces. We obtain formulas for the Hausdorff dimension of such cutouts in self-similar and self-conformal spaces using the multifractal decomposition of the average densities for the natural measures.

Detection of oxidative mutagenesis by isoniazid and other hydrazine derivatives in Escherichia coli WP2 tester strain IC203, deficient in OxyR: stron…

1998

Abstract Strain IC203, deficient in the OxyR function, was sensitive to both cytotoxic and mutagenic effects of isoniazid (INH) whereas its parent, WP2 uvrA /pKM101, was resistant to these effects. Four other hydrazine compounds, hydrazine hydrate (HZH), phenylhydrazine (PHZ), hydralazine (HLZ) and nialamide (NLD), were mutagenic in WP2 uvrA /pKM101. Increases in mutagenicity were observed in IC203 for HZH and PHZ but not for HLZ and NLD. Growth inhibition zones by HZH, PHZ and NLD were larger in IC203 than in WP2 uvrA /pKM101. The enhancements in the effects of INH, HZH and PHZ in IC203 with respect to its oxyR + parent are considered to be caused by the production of reactive oxygen speci…

Data from: Phylogenomics of Lophotrochozoa with consideration of systematic error

2021

Phylogenomic studies have improved understanding of deep metazoan phylogeny and show promise for resolving incongruences among analyses based on limited numbers of loci. One region of the animal tree that has been especially difficult to resolve, even with phylogenomic approaches, is relationships within Lophotrochozoa (the animal clade that includes molluscs, annelids, and flatworms among others). Lack of resolution in phylogenomic analyses could be due to insufficient phylogenetic signal, limitations in taxon and/or gene sampling, or systematic error. Here, we investigated why lophotrochozoan phylogeny has been such a difficult question to answer by identifying and reducing sources of sys…

Data from: Phylogenomics of Lophotrochozoa with consideration of systematic error

2016

Phylogenomic studies have improved understanding of deep metazoan phylogeny and show promise for resolving incongruences among analyses based on limited numbers of loci. One region of the animal tree that has been especially difficult to resolve, even with phylogenomic approaches, is relationships within Lophotrochozoa (the animal clade that includes molluscs, annelids, and flatworms among others). Lack of resolution in phylogenomic analyses could be due to insufficient phylogenetic signal, limitations in taxon and/or gene sampling, or systematic error. Here, we investigated why lophotrochozoan phylogeny has been such a difficult question to answer by identifying and reducing sources of sys…

Arena birds

1995

Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease

2010

Oxidative stress is involved in the pathogenesis of various neurodegenerative disorders, conventional antioxidant strategies have yet been of limited success. We have employed transgenic Caenorhabditis elegans expressing DsRed2 in dopaminergic neurons and CFP pan-neuronally, to characterize in larval and adult animals the effects of rotenone and 1-methyl-4-phenyl-pyridinium (MPP(+)) on the dopaminergic system. Investigating the antioxidant phenothiazine and different derived antipsychotic drugs, it was found that free phenothiazine exerted strong neuroprotection at the cellular level and resulted in a better performance in behavioral assays, whereas apomorphine and other dopamine agonists o…