Search results for "Spins"

showing 10 items of 257 documents

Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR

2014

International audience; : Transverse and longitudinal relaxation times (T1ρ and T1 ) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be more sensitive to ligand binding. LLS can be excited if the ligand comprises at least two coupled spins. Herein we broaden the scope of ligand screening by LLS to arbitrary ligands by covalent attachment of a functional group, which comprises a pair of coupled protons that are isolated from neighboring magnetic nuclei. The resulting functionalized ligands have longitudinal relaxation times T1 ((1) H) that are sufficiently long to allow the powerf…

BromidesMagnetic Resonance SpectroscopyStereochemistryDrug Evaluation PreclinicalThiophenesLigands010402 general chemistry01 natural sciencesBiochemistrydynamic nuclear polarizationchemistry.chemical_compoundNMR spectroscopyCatalytic DomainDrug DiscoveryGeneral Pharmacology Toxicology and PharmaceuticsPharmacologySpins[CHIM.ORGA]Chemical Sciences/Organic chemistry010405 organic chemistryDrug discoveryOrganic ChemistryRelaxation (NMR)ProteinsNuclear magnetic resonance spectroscopyFull PapersLigand (biochemistry)0104 chemical sciencesCrystallographychemistryCovalent bondlong-lived statesExcited stateFunctional groupMolecular MedicineChemMedChem
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Photochemically induced dynamic nuclear polarization of heteronuclear singlet order

2021

Photochemically induced dynamic nuclear polarization (photo-CIDNP) is a method to hyperpolarize nuclear spins using light. In most cases, CIDNP experiments are performed in high magnetic fields and the sample is irradiated by light inside a nuclear magnetic resonance (NMR) spectrometer. Here we demonstrate photo-CIDNP hyperpolarization generated in the Earth's magnetic field and under zero- to ultralow-field (ZULF) conditions. Irradiating a sample containing tetraphenylporphyrin and para-benzoquinone for several seconds with light-emitting diodes produces strong hyperpolarization of 1H and 13C nuclear spins, enhancing the NMR signals more than 200 times. The hyperpolarized spin states at th…

Chemical Physics (physics.chem-ph)Materials scienceSpin statesSpinsField (physics)CIDNPPhysics::Medical PhysicsFOS: Physical sciences02 engineering and technology010402 general chemistry021001 nanoscience & nanotechnologyPolarization (waves)7. Clean energy01 natural sciences0104 chemical sciencesMagnetic fieldHeteronuclear moleculePhysics - Chemical Physicsddc:530General Materials ScienceSinglet statePhysical and Theoretical ChemistryAtomic physics0210 nano-technology
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Magnetoelectric effect in mixed valency oxides mediated by charge carriers

2008

We show that the presence of free carriers in a substance can generate the multiferroic behavior. Namely, if the substance has mixed-valence ions, which can supply free carriers and have electric dipole and spin moments, all three types of long-range order (ferromagnetic, ferroelectric and magnetoelectric (ME)) can occur at low temperature. The physical origin of the effect is that charge carriers can mediate the multiferroic behavior via spin - spin (RKKY), dipole-dipole and dipole - spin interactions. Our estimate of the interaction magnitude shows that there exist an optimal carrier concentration, at which the strength of ME interaction is maximal and comparable to that of spin-spin RKKY…

Condensed Matter - Materials ScienceMaterials scienceRKKY interactionSpinsCondensed matter physicsMagnetoelectric effectGeneral Physics and AstronomyMaterials Science (cond-mat.mtrl-sci)FOS: Physical sciencesDisordered Systems and Neural Networks (cond-mat.dis-nn)Condensed Matter - Disordered Systems and Neural NetworksFerroelectricityDipoleCondensed Matter::Materials ScienceFerromagnetismMultiferroicsCharge carrierCondensed Matter::Strongly Correlated ElectronsComputer Science::Databases
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Transversal spin freezing and re-entrant spin glass phases in chemically disordered Fe-containing perovskite multiferroics

2015

We propose experimental verification and theoretical explanation of magnetic anomalies in the complex Fe-contained double perovskite multiferroics like PbFe$_{1/2}$Nb$_{1/2}$O$_3$. The theoretical part is based on our model of coexistence of long-range magnetic order and spin glass in the above substances. In our model, the exchange interaction is anisotropic, coupling antiferromagnetically $z$ spin components of Fe$^{3+}$ ions. At the same time, the $xy$ components are coupled by much weaker exchange interaction of ferromagnetic sign. In the system with spatial disorder (half of corresponding lattice cites are occupied by spinless Nb$^{5+}$ ions) such frustrating interaction results in the…

Condensed Matter - Materials ScienceSpin glassMaterials scienceCondensed matter physicsSpinsExchange interactionMaterials Science (cond-mat.mtrl-sci)FOS: Physical sciencesGeneral Physics and Astronomy02 engineering and technology021001 nanoscience & nanotechnology01 natural sciencesFerromagnetismLattice (order)0103 physical sciencesAntiferromagnetismCondensed Matter::Strongly Correlated ElectronsMultiferroicsPhysical and Theoretical Chemistry010306 general physics0210 nano-technologyAnisotropyPhysical Chemistry Chemical Physics
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Random Variables Recorded Under Mutually Exclusive Conditions: Contextuality-by-Default

2014

We present general principles underlying analysis of the dependence of random variables (outputs) on deterministic conditions (inputs). Random outputs recorded under mutually exclusive input values are labeled by these values and considered stochastically unrelated, possessing no joint distribution. An input that does not directly influence an output creates a context for the latter. Any constraint imposed on the dependence of random outputs on inputs can be characterized by considering all possible couplings (joint distributions) imposed on stochastically unrelated outputs. The target application of these principles is a quantum mechanical system of entangled particles, with directions of …

Constraint (information theory)SpinsJoint probability distributionControl theoryContext (language use)Statistical physicsMutually exclusive eventsRandom variableKochen–Specker theoremMathematicsSpin-½
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Nonbonded Indirect Nuclear Spin–Spin Couplings (J Couplings “Through-Space”) for Structural Determination in Small Organic and Organometallic Species

2013

Abstract Spin–spin coupling constant J provides decisive data for organic compound characterization. This electron-mediated coupling is usually taught as transmitted between covalently bonded magnetic atoms. However, this physical interaction between nuclear spins is much more complex than that with regard to chemical bonding concept. Independent experimental and theoretical studies related to small organic and organometallic species (molecular mass below 2000 g mol − 1 ) have highlighted the existence of J couplings operating via clearly nonbonded interactions and known as “through-space” couplings. Interactions of this type are frequently reported and couplings involving 19  F, 13 C, 77 S…

Coupling constantCouplingChemical bondSpinsHydrogen bondComputational chemistryChemistrySpin (physics)Characterization (materials science)Group 2 organometallic chemistry
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Nuclear Spins of the IsomersHg191m−185mDetermined by On-Line Quantum-Beat Spectroscopy

1979

The nuclear spins of the very neutron-deficient $^{191m\ensuremath{-}185m}\mathrm{Hg}$ isomers were measured on line at the mass separator ISO LIDE at CERN using pulsed-laser excitation and observation of the time-resolved quantum beats from selected hyperfine-structure states. The spins of these isomers are with $I=\frac{13}{2}$ equal to those of the long-lived isomers $^{199m\ensuremath{-}193m}\mathrm{Hg}$ already known. The persistence of this spin value for eight isomers is explained by the model of rotation-aligned coupling.

Coupling constantPhysicsAngular momentumQuantum beatsIsotopeSpinsPhysics::Atomic and Molecular ClustersGeneral Physics and AstronomyPhysics::Chemical PhysicsAtomic physicsSpectroscopyHyperfine structureExcitationPhysical Review Letters
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Tripartite thermal correlations in an inhomogeneous spin-star system

2010

We exploit the tripartite negativity to study the thermal correlations in a tripartite system, that is the three outer spins interacting with the central one in a spin-star system. We analyze the dependence of such correlations on the homogeneity of the interactions, starting from the case where central-outer spin interactions are identical and then focusing on the case where the three coupling constants are different. We single out some important differences between the negativity and the concurrence.

Coupling constantPhysicsQuantum PhysicsSpinsCondensed matter physicsFOS: Physical sciencesConcurrenceNegativity effectCondensed Matter PhysicsAtomic and Molecular Physics and OpticsStar systemThermalHomogeneity (physics)Quantum Physics (quant-ph)Entanglement Thermodynamics Spin systems
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Effective hamiltonian approach to the non-Markovian dynamics in a spin-bath

2010

We investigate the dynamics of a central spin that is coupled to a bath of spins through a non-uniform distribution of coupling constants. Simple analytical arguments based on master equation techniques as well as numerical simulations of the full von Neumann equation of the total system show that the short-time damping and decoherence behaviour of the central spin can be modelled accurately through an effective Hamiltonian involving a single effective coupling constant. The reduced short-time dynamics of the central spin is thus reproduced by an analytically solvable effective Hamiltonian model.

Coupling constantPhysicsQuantum decoherenceSpinsHamiltonian modelMarkov processCondensed Matter PhysicsAtomic and Molecular Physics and Opticssymbols.namesakeClassical mechanicsQuantum mechanicsMaster equationsymbolsHamiltonian (quantum mechanics)opens systems effective hamiltonians quantum noise non-markovian dynamicsMathematical PhysicsVon Neumann architecture
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HP-Xe to go: Storage and Transportation of Hyperpolarized 129-Xe

2016

Abstract Recently the spin–lattice relaxation time T 1 of hyperpolarized (HP)- 129 Xe was significantly improved by using uncoated and Rb-free storage vessels of GE180 glass. For these cells, a simple procedure was established to obtain reproducible wall relaxation times of about 18 h. Then the limiting relaxation mechanism in pure Xe is due to the coupling between the nuclear spins and the angular momentum of the Xe–Xe van-der-Waals-molecules. This mechanism can be significantly reduced by using different buffer gases of which CO 2 was discovered to be the most efficient so far. From these values, it was estimated that for a 1:1 mixture of HP-Xe with CO 2 a longitudinal relaxation time of …

CouplingNuclear and High Energy PhysicsAngular momentumSpinsCondensed matter physicsChemistryRelaxation (NMR)BiophysicsAnalytical chemistrychemistry.chemical_element010402 general chemistryCondensed Matter Physics01 natural sciencesBiochemistry0104 chemical sciencessymbols.namesakeXenon0103 physical sciencessymbolsvan der Waals forceTotal pressure010306 general physicsLongitudinal Relaxation Time
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