Search results for "Stalk"
showing 10 items of 116 documents
Stalking: definizione del costrutto, aspetti fenomenologici, comportamenti associati.
2011
Objectives: Scientific literature on stalking behaviors is not sufficiently uniform and shows no clear definition of the theorical construct of stalking. In order to respond to current scientific criteria for defining a psychological and behavioral construct, the definition of "stalking" should be exhaustive and specific at the same time. There must be also a positive consensus by scholars on a definition of a construct, for that definition becoming operationalized and therefore profitably appliable in theory and research. Methods: Exploring the theoretical definitions of stalking that are privileged in current literature, and reviewing the different behavioral markers suggested for identif…
LA CASSAZIONE ALLE PRESE CON LO STALKING COMMESSO A MEZZO FACEBOOK
2021
Recruitment of Xrn1 to stress-induced genes allows efficient transcription by controlling RNA polymerase II backtracking
2020
A new paradigm has emerged proposing that the crosstalk between nuclear transcription and cytoplasmic mRNA stability keeps robust mRNA levels in cells under steady-state conditions. A key piece in this crosstalk is the highly conserved 5′–3′ RNA exonuclease Xrn1, which degrades most cytoplasmic mRNAs but also associates with nuclear chromatin to activate transcription by not well-understood mechanisms. Here, we investigated the role of Xrn1 in the transcriptional response of Saccharomyces cerevisiae cells to osmotic stress. We show that a lack of Xrn1 results in much lower transcriptional induction of the upregulated genes but in similar high levels of their transcripts because of parallel …
Rpb4 and Puf3 imprint and post-transcriptionally control the stability of a common set of mRNAs in yeast
2020
ABSTRACTGene expression involving RNA polymerase II is regulated by the concerted interplay between mRNA synthesis and degradation, crosstalk in which mRNA decay machinery and transcription machinery respectively impact transcription and mRNA stability. Rpb4, and likely dimer Rpb4/7, seem the central components of the RNA pol II governing these processes. In this work we unravel the molecular mechanisms participated by Rpb4 that mediate the posttranscriptional events regulating mRNA imprinting and stability. By RIP-Seq, we analyzed genome-wide the association of Rpb4 with mRNAs and demonstrated that it targeted a large population of more than 1400 transcripts. A group of these mRNAs was als…
The total mRNA concentration buffering system in yeast is global rather than gene-specific
2021
Gene expression in eukaryotes does not follow a linear process from transcription to translation and mRNA degradation. Instead it follows a circular process in which cytoplasmic mRNA decay crosstalks with nuclear transcription. In many instances, this crosstalk contributes to buffer mRNA at a roughly constant concentration. Whether the mRNA buffering concept operates on the total mRNA concentration or at the gene-specific level, and if the mechanism to do so is a global or a specific one, remain unknown. Here we assessed changes in mRNA concentrations and their synthesis rates along the transcriptome of aneuploid strains of the yeast Saccharomyces cerevisiae. We also assessed mRNA concentra…
BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians
2020
B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways. Although in these latter cases, BCL-xL has dual roles, either activating or inhibiting, depending on the cell type and the specific conditions. Taken together, all these findings suggest a precise mechanism of action for BCL-xL, able to regulate the crosstalk between apoptosis, autophagy, and senescence, thus promoting cell survival or cell death. All three pathways…
Introduzione
2012
Dark consequences of social media-induced fear of missing out (FoMO): Social media stalking, comparisons, and fatigue
2021
Research on the dark side of social media usage has explored the fear of missing out (FoMO), social media fatigue (fatigue), social media stalking (stalking), and online social comparison (social comparison) independently. Accordingly, the complex interrelationships among these phenomena have remained understudied, creating a chasm that hinders a clearer understanding of their drivers and the potential counterstrategies to mitigate the collateral damage they may cause. We attempt to bridge this gap by drawing upon the theory of social comparison and the theory of compensatory internet use to formulate a framework that hypothesizes the mechanism of interaction among these negative fallouts. …
Novel photoreception system in sponges?
2006
Abstract Sponges (phylum Porifera) of the classes Hexactinellida and Demospongiae possess a skeleton composed of siliceous spicules, which are synthesized enzymatically. The longest spicules are found among the Hexactinellida, with the stalk spicules (length: 30 cm; diameter: 300 μm) of Hyalonema sieboldi as prominent examples. These spicules are constructed around a central axial filament, which is formed by approximately 40 siliceous layers. The stratified spicules function as optical glass fibers with unique properties. If free-spaced coupled with a white light source (WLS), the entire fiber is illuminated. Special features of the light transmission: (i) only wavelengths between 615 and …
Il Cyberstalking
2015
Il Cyberstalking è una forma diffusa di molestia effettuata tramite l'utilizzo delle nuove tecnologie, come e-mail, chat e social network. Si stima che tra il 2-13% e l'8-32% delle donne negli Stati Uniti è vittima di cyberstalking. Il crescente interesse per questo nuovo crimine informatico è testimoniato dal recente adeguamento del sistema legislativo italiano (art. 612-bis del Codice Penale). Le azioni dei cyberstalker potrebbero essere mosse dal desiderio di vendetta, da un'ossessione d'amore o dalla ricerca di intimità.