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Psicopatología e imagen corporal y su relación con constructos salutogénicos en la adolescencia
2016
El objetivo del presente trabajo es evaluar la incidencia de la psicopatología, sintomatología clínica y alteraciones de la imagen corporal en las variables salutogénicas estilos de apego, bienestar psicológico y auto concepto, así como la incidencia de diferencias individuales. La muestra está compuesta por 675 adolescentes valencianos (470 chicos y 255 chicas) de entre 13 y 18 años (M=15.44 y DT=1.76). Los instrumentos empleados, todos ellos validados en población española son: Cuestionario de 90 Síntomas Revisado (SCL-90-R) de Leonard y Derogatis (1994), Test de Siluetas para Adolescentes (TSA) de Maganto y Cruz (2008), Escala de Tipos de Apego para Adolescentes de Casullo y Fernández (2…
Ārējās tirdzniecības problēmas Latvijā
2015
Maģistra darbā „Ārējās tirdzniecības problēmas Latvijā” tiek pētīti un salīdzināti Latvijas eksporta un importa dati. Maģistra darba mērķis ir, pamatojoties uz zinātnisko literatūru, normatīvo aktu izpēti un statistisko datu analīzi, sniegt ārējās tirdzniecības teorētisko pamatojumu, izanalizēt ārējās tirdzniecības dinamiku un struktūru Latvijā, kā arī veikt ārējās tirdzniecības problēmu analīzi Latvijas nozīmīgākajās nozarēs. Darba mērķa sasniegšanai galvenie darba uzdevumi: •pamatojoties uz zinātnisko literatūru, izpētīt starptautisko tirdzniecības vēsturi un to nozīmi mūsdienās; •izanalizēt Latvijas ārējās tirdzniecības dinamiku un struktūru un to svārstību ietekmējošos iemeslus; •izvirz…
Incógnitas del 11 de Septiembre
2002
Artículo también publicado en "ADE teatro: Revista de la Asociación de Directores de Escena de España", nº 91, pp. 30-31, 2002.
RT-PCR and in situ hybridization analysis of apolipoprotein H expression in rat normal tissues
2006
In this study, by using different techniques (i.e. Northern blot hybridization, RT-PCR and Southern blot hybridization) on various normal rat tissues, we were able to identify liver, kidney, heart, small intestine, brain, spleen, stomach and prostate as tissues in which the ApoH gene is transcribed. Moreover, for some of these tissues, by in situ hybridization, we found a specific localization of apoH transcripts. For instance epithelial cells of the bile ducts in liver and of the proximal tubules in kidney are the major sites of apoH synthesis. Our data suggest that some of the different physiological roles proposed for apoH could correlate with its direct expression, while others could co…
In situ kinetic modelling of intestinal efflux in rats: functional characterization of segmental differences and correlation with in vitro results.
2007
The objective was to devise and apply a novel modelling approach to combine segmental in situ rat perfusion data and in vitro cell culture data, in order to elucidate the contribution of efflux in drug absorption kinetics. The fluoroquinolone CNV97100 was used as a model P-gp substrate. In situ intestinal perfusion was performed in rat duodenum, jejunum, ileum and colon to measure the influence of P-gp expression on efflux. Inhibition studies of CNV97100 were performed in the presence of verapamil, quinidine, cyclosporin A and p-aminohippuric acid. Absorption/efflux parameters were modelled simultaneously, using data from both in situ studies as well as in vitro studies. The maximal efflux …
In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model.
2015
Our aim is to develop and to validate the in situ closed loop perfusion method in rat colon and to compare with small intestine and Caco-2 cell models. Correlations with human oral fraction absorbed (Fa) and human colon fraction absorbed (Fa_colon) were developed to check the applicability of the rat colon model for controlled release (CR) drug screening. Sixteen model drugs were selected and their permeabilities assessed in rat small intestine and colon, and in Caco-2 monolayers. Correlations between colon/intestine/Caco-2 permeabilities versus human Fa and human Fa_colon have been explored to check model predictability and to apply a BCS approach in order to propose a cut off value for CR…
Profile of P-glycoprotein distribution in the rat and its possible influence on the salbutamol intestinal absorption process.
2004
8 pages, 2 figures, 2 tables.--PMID: 15124220 [PubMed]
In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluis…
2015
Intestinal drug permeability has been recognized as a critical determinant of the fraction dose absorbed, with direct influence on bioavailability, bioequivalence and biowaiver. The purpose of this research was to compare intestinal permeability values obtained by two different intestinal rat perfusion methods: the single-pass intestinal perfusion (SPIP) model and the Doluisio (closed-loop) rat perfusion method. A list of 15 model drugs with different permeability characteristics (low, moderate, and high, as well as passively and actively absorbed) was constructed. We assessed the rat intestinal permeability of these 15 model drugs in both SPIP and the Doluisio methods, and evaluated the co…
Industrial application of selected lactic acid bacteria isolated from local semolinas for typical sourdough bread production
2016
Abstract Four obligate heterofermentative lactic acid bacteria (LAB) strains (Weissella cibaria PON10030 and PON10032 and Leuconostoc citreum PON 10079 and PON10080) were tested as single strain starters, mono-species dual strain starters, and multiple strain starter for the preparation and propagation of sourdoughs for the production of a typical bread at industrial level. The kinetics of pH and TTA during the daily sourdough refreshments indicated a correct acidification process for all trials. The concentration of lactic and acetic acid increased consistently during fermentation. The resulting molar ratios between these two organic acids in the experimental trials were lower than those o…
Age-related changes of NADPH-diaphorase-positive neurons in the rat inferior colliculus and auditory cortex
2007
Nitric oxide (NO) has been implied in age-related changes of the central nervous system (CNS) and the central auditory pathway. The present study was conducted to investigate whether the number of NO-producing cells and their morphometric characteristics in the inferior colliculus (IC) and the auditory cortex (AC) are changed with the increasing age of the subjects. IC and AC sections of adult and senile Wistar rats were studied using the histochemical detection of NADPH-diaphorase activity (NADPH-d), a marker for neurons containing nitric oxide synthase (NOS). Our results showed a decreased area of the somas of NADPH-d-positive neurons in the dorsal cortex (DC) of the IC and a diffuse loss…