Search results for "Static"

The impacts of the ALE and hydrostatic-pressure approaches on the energy budget of unsteady free-surface flows

2008

Abstract This paper focuses on the energy budget in the calculation of unsteady free-surface flows on moving grids with and without using the ‘arbitrary Lagrangian–Eulerian’ (ALE) formulation or hydrostatic-pressure assumption. The numerical tool is an in-house general-purpose solver for the unsteady, incompressible and homogeneous Navier–Stokes equations in a Cartesian domain. An explicit fractional-step method and co-located finite-volume method are used for the second-order accurate integrations in time and space. The test cases are nonlinear and linear irrotational standing waves, which allow to characterise the impacts of an ALE or Eulerian formulation with moving grids by comparison w…

PSYCHOBEHAVIORAL DISORDERS, ORTHOSTATIC HYPOTENSION, AND FALLS RELATED TO A PHEOCHROMOCYTOMA IN A VERY ELDERLY SUBJECT: A CASE REPORT

2010

Melanoma Clinics and Treatment

2013

Allostatic Load and Children’s Disease

2021

Abstract Allostatic (over)load appears to be a substantial cause of morbidity for adults. For children, new aspects emerge. They are particularly significant for their repercussions in childhood and adult life: obesity, metabolic syndrome, arterial hypertension, insulin resistance, or eating disorder. It is desirable to identify clusters relevant for certain diseases to prevent long-time and irreversible consequences of allostatic load.

Neuroendocrine indicators of allostatic load reveal the impact of environmental acidification in fish

2020

Abstract When mobilized from surrounding soils and binding to gills at moderately low pH, aluminum (Al) cations can adversely affect fish populations. Furthermore, acidification may lead to allostatic overload, a situation in which the costs of coping with chronic stress affects long-term survival and reproductive output and, ultimately, ecosystem health. The brain's serotonergic system plays a key role in neuroendocrine stress responses and allostatic processes. Here, we explored whether sublethal effects of Al in acidified water affects serotonergic neurochemistry and stress coping ability in a unique land-locked salmon population from Lake Bygelandsfjorden, in southern Norway. Fish were …

Effects of repeated short episodes of environmental acidification on Atlantic salmon (Salmo salar) from a landlocked population

2020

Abstract Chronic or repeated exposure to environmental contaminants may result in allostatic overload, a physiological situation in which the costs of coping affect long-term survival and reproductive output. Continuous measurements in Otra, the largest river in southern Norway, show the occurrence of repeated 24–48 h episodes of acidification. This work investigates the impact of repeated short acidification episodes on a unique land-locked population of normally anadromous Atlantic salmon (“Bleke”). This was done by recording physiological measures of stress and allostatic load in fish exposed for 7 days to continuous or repeated episodes of simulated environmental acidification or untrea…

Carbon dioxide degassing from Tuscany and Northern Latium (Italy)

2008

Abstract The CO 2 degassing process from a large area on the Tyrrhenian side of central Italy, probably related to the input into the upper crust of mantle fluids, was investigated in detail through the geochemical study of gas emissions and groundwater. Mass-balance calculations and carbon isotopes show that over 50% of the inorganic carbon in regional groundwater is derived from a deep source highlighting gas−liquid separation processes at depth. The deep carbonate−evaporite regional aquifer acts as the main CO 2 reservoir and when total pressure of the reservoir fluid exceeds hydrostatic pressure, a free gas phase separates from the parent liquid and escapes toward the surface generating…

(R)-NODAGA-PSMA: A Versatile Precursor for Radiometal Labeling and Nuclear Imaging of PSMA-Positive Tumors

2015

Purpose The present study aims at developing and evaluating an urea-based prostate specific membrane antigen (PSMA) inhibitor suitable for labeling with 111In for SPECT and intraoperative applications as well as 68Ga and 64Cu for PET imaging. Methods The PSMA-based inhibitor-lysine-urea-glutamate-coupled to the spacer Phe-Phe-D-Lys(suberoyl) and functionalized with the enantiomerically pure prochelator (R)-1-(1-carboxy-3-carbotertbutoxypropyl)-4,7-carbotartbutoxymethyl)-1,4,7-triazacyclononane ((R)-NODAGA(tBu)3), to obtain (R)-NODAGA-Phe-Phe-D-Lys(suberoyl)-Lys-urea-Glu (CC34). CC34 was labeled with 111In, 68Ga and 64Cu. The radioconjugates were further evaluated in vitro and in vivo in LNC…

On the Relationship between Jetted Inks and Printed Biopatterns:Molecular-Thin Functional Microarrays of Glucose Oxidase

2009

Arrays of circular spots of glucose oxidase have been obtained on functionalized silicon oxide by piezoelectric inkjet printing and the enzymatic activity toward glucose recognition has been monitored. The addition of glycerol to the molecular ink allows to obtain high spot definition and resolution (tens of micrometers wide; one molecule tall), but in spite of its well-known structural stabilizing properties, in dynamic conditions it may lead to increased protein stresses. The jetting voltage and pulse length have been found to be critical factors for both activity retention and pattern definition. High voltages and pulse lengths results in stress effects along with the loss of activity, w…

Pressure inactivation kinetics of Enterobacter sakazakii in infant formula milk

2007

Survival curves of Enterobacter sakazakii inactivated by high hydrostatic pressure were obtained at four pressure levels (250, 300, 350, and 400 MPa), at temperatures below 30 degrees C, in buffered peptone water (BPW; 0.3%, wt/vol) and infant formula milk (IFM; 16%, wt/vol). A linear model and four nonlinear models (Weibull, log-logistic, modified Gompertz, and Baranyi) were fitted to the data, and the performances of the models were compared. The linear regression model for the survival curves in BPW and IFM at 250 MPa has fitted regression coefficient (R2) values of 0.940 to 0.700, respectively, and root mean square errors (RMSEs) of 0.770 to 0.370. For the other pressure levels, the lin…