Search results for "Surge"
showing 10 items of 18826 documents
L’emploi de méthodes mathématiques pour détecter la présence de potentiels évoqués dans le coma : un aide ou un fardeau ?
2016
Un des defis majeurs auxquels sont confrontes les services de reanimation est de pouvoir predire precisement et precocement vers quel etat evoluera la conscience des patients dans le coma pour anoxie cerebrale. Afin d’obtenir des indices directs sur l’etat cerebral fonctionnel, l’emploi des potentiels evoques est recommande, et notamment l’enregistrement de la negativite de discordance (MMN). La MMN est une onde cerebrale apparaissant entre 100 et 200 ms apres l’apparition d’un nouveau stimulus dans une sequence de stimuli identique et sa presence est un signe fort de recuperation. Le standard dans la determination de la presence d’une onde MMN en pratique clinique est l’analyse visuelle pa…
La alteración de la mielina en la enfermedad de Alexander
2018
Resumen: Introducción: La enfermedad de Alexander (AxD) es una leucodistrofia. Su base patológica, junto a la pérdida de mielina, es la aparición de los cuerpos de Rosenthal, que son inclusiones citoplasmáticas en células astrocitarias. Mutaciones en el gen que codifica la GFAP se han identificado como una base genética para AxD. Sin embargo, no se conoce el mecanismo por el cual estas variantes producen la enfermedad. Desarrollo: La hipótesis más extendida es que AxD se desarrolla por un mecanismo por ganancia de función debido al incremento de GFAP. Sin embargo, este mecanismo no explica la pérdida mielínica, dado que los modelos experimentales que expresan GFAP normal o mutada no generan…
Reply from Mari Carmen Gomez-Cabrera and Jose Viña
2017
Il neonato con gli occhi socchiusi. La displasia ectodermica legata al gene TP63
2021
An Italian female newborn presented with cleft palate, erythroderma, desquamations, skin erosions, ankyloblepharon filiforme adnatum, broad nasal root, short philtrum, thin vermillion border, maxillary hypoplasia, microstomia, microglossia, cupped ears, hypoplasia of the distal phalange of left index, widely spaced nipples and polythelia. The hallmarks of ankyloblepharon-ectodermal dysplasia-clefting syndrome (or Hay-Wells syndrome) as well as persistent scalp erosions led to exclude more frequent skin disorders like congenital ichthyosiform erythroderma or epidermolysis bullosa and to diagnose Hay-Wells syndrome by genetic analysis. Target sequencing of the tumour protein p63 (TP63) gene r…
Clinical effect of diode laser on peri-implant tissues during non-surgical peri-implant mucositis therapy: Randomized controlled clinical study
2019
Background: The aim of this study is to evaluate the response to the non-surgical treatment of peri-implant mucositis using the diode laser as an adjuvant therapy in patients with implant-supported restorations, in terms of clinical variables, with respect to those patients in whom conventional non-surgical therapy is used. Material and Methods: Randomized controlled clinical trial with simple blind 3 months follow-up. Two groups of patients were established, the non-surgical mechanical debridement of the affected implants was performed in the control group (n = 34) and the diode laser therapy was also performed in the test group (n = 34). The implant was considered the study subject; the v…
Extensive osteonecrosis of the maxilla caused by bisphosphonates: Report of a rare case
2019
Bisphosphonates are drugs indicated for the treatment of bone metabolic diseases or malignant hypercalcemia. They are generally well-tolerated drugs, however, recent reports have described osteonecrosis of the jaw bones as a potentially serious complication related to the long-term use of these drugs. We report a case of severe osteonecrosis in a 52-years-old white woman that was taking bisphosphonates (zoledronic acid and alendronate) for the management of osteoporosis. Following a long exposure to these drugs and after being subjected to multiples exodontias, developed bisphosphonate-related osteonecrosis of the jaw compromising the whole maxilla and that extended toward the base of skull…
Adolescent Feeding: Nutritional Risk Factors
2018
AbstractThe aim of this review is to describe adolescent nutritional requirements from a scientific, nutritional, and psychosocial point of view, emphasizing the main risks of malnutrition at this age. Currently, too many teenagers are alone at home and prepare their own meals. The influence of friends replaces parental rules. The habits of adolescents are characterized by a tendency to skip meals, especially breakfast, and, less frequently, the midday meal; to purchase carry-out meals away from home; to consume snacks, especially sweets; to eat at fast food restaurants, almost always with high-calorie content; and to eat fried foods, soft drinks, and sweets. Toxic habits, such as smoking, …
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
2017
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, …
Meridianos tendinomusculares (Jīng Jīn) y tejido fascial, comparativa anatómica y funcional
2016
The description of the pathways of the Jīng Jīn meridians is based on empirical observations carried out more than 2000 years ago, and though historical records have shown their possible anatomical basis, nowadays these energetic pathways lack a solid scientific base from the biomedical standpoint. Nonetheless, the comparison between the pathways and function of the Jīng Jīn with the new insights regarding contributions to anatomy and physiology of the fascial system brought from western medicine allows for meeting points and closer relations between the two areas of knowledge. Physiologically, both the Jīng Jīn and the fascial system participate in common structural, biomechanical, integra…
TReND in Africa: Toward a Truly Global (Neuro)science Community
2020
TReND is a volunteer-scientist run charity dedicated to promoting research and education on the African continent. Focusing on neuroscience, we discuss approaches to address some of the factors that currently stifle Africa's scientific development and our experience in implementing them.