Search results for "System a"

Clinical cardiac assessment in newborns with prenatally diagnosed intrathoracic masses

2018

Abstract Background Congenital space-occupying thoracic malformations and diaphragmatic hernia have in common pulmonary hypoplasia. Our study aims to assess cardiac involvement during post-natal adaptation. Methods A retrospective study was carried out on newborns with prenatally diagnosed intrathoracic mass. Gathering for respiratory distress syndrome (RDS), 35 neonates were compared for clinical course, cardiovascular enzymes, ECG, and ultrasound. Results The analysis revealed a high left heart defect rate in patients with severe RDS, without being influenced by the laterality. Ultrasound or laboratory assessment did not detect altered cardiac dimension or cardiomyopathy. Solely ECG signs…

English and French Modes of Regulation of the Education System : a comparison

2003

03069; International audience; This paper describes English and French modes of regulation of the educational system, stressing the contrast between them (regulation by process versus regulation by outcomes), while their goals and organisation prove rather more convergent over the last 30 years. It tries to assess the correspondence between those two ways of operating and what we know about the functioning of organisations like schools. From that point of view, the French system fits the economic theory of organisation less well than the English one, so that some contradictions and tensions are predictable. Last, it looks for some relationhip with indicators of effectiveness, equity and soc…

Role of oxoproline in the regulation of neutral amino acid transport across the blood-brain barrier.

1996

Regulation of neutral amino acid transport was studied using isolated plasma membrane vesicles derived from the bovine blood-brain barrier. Neutral amino acids cross the blood-brain barrier by facilitative transport system L1, which may allow both desirable and undesirable amino acids to enter the brain. The sodium-dependent amino acid systems A and Bo,+ are located exclusively on abluminal membranes, in a position to pump unwanted amino acids out. gamma-Glutamyl transpeptidase, the first enzyme of the gamma-glutamyl cycle, is an integral protein of the luminal membrane of the blood-brain barrier. We demonstrate that oxoproline, an intracellular product of the gamma-glutamyl cycle, stimulat…

Challenging or Accommodating the Football System? A Case Study of Female Football Supporter Communities in Spain

2018

The chapter is dedicated to the study of a specific type of football community that emerged during the 1980s in Spain: women’s penas. Llopis-Goig and Flores discuss how women’s link to these penas provides them with networks of support and sociability, bonds of friendship and integration in a community as well as a door to the public space that helps them avoid the isolation of a nuclear family for some women. Thus, the female fans generate empowerment strategies that allow them to gradually combat the discrimination experienced in football and in society. However, Llopis-Goig and Flores argue that women’s penas cannot be regarded as initiatives that question the patriarchal structure of fo…

Book Review

2020

Is integration of Uncertainty Management and The Last Planner System a good idea?

2018

The Last Planner System (LPS) is a tool for project planning and control, and is an important contribution from Lean Construction. LPS focuses on scheduling, task coordination and time management. Uncertainty Management (UM) is a key element in Project Management, where uncertainty is the totality of opportunities (potential upsides) and risks (potential downsides). UM addresses all types of uncertainty (related to cost, time, quality, scope, safety, customer satisfaction, company reputation, etc.). The aim of UM is to exploit the opportunities and reduce the risks. Two construction companies involved in this research are working with both LPS and UM. One has extensive experience with LPS, …

SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress.

2005

AbstractUnder hypertonic conditions the induction of SLC38A2/SNAT2 leads to the stimulation of transport system A and to the increase in the cell content of amino acids. In hypertonically stressed human fibroblasts transfection with two siRNAs for SNAT2 suppressed the increase in SNAT2 mRNA and the stimulation of system A transport activity. Under the same condition, the expansion of the intracellular amino acid pool was significantly lowered and cell volume recovery markedly delayed. It is concluded that the up-regulation of SNAT2 is essential for the rapid restoration of cell volume after hypertonic stress.

Role of hydrophobicity on the monoamine receptor binding affinities of central nervous system drugs: a quantitative retention-activity relationships …

2004

Abstract Biological action and activity reflect an aspect of the fundamental physicochemical properties of the bioactive compounds. As an alternative to classical QSAR studies, in this work different quantitative retention–activity relationships (QRAR) models are proposed, which are able to describe the role of hydrophobicity on the binding affinity to different brain monoamine receptors (H 1 -histamine, α 1 -noradrenergic and 5-HT 2 -serotonergic) of different families of psychotherapeutic drugs. The retention of compounds is measured in a biopartitioning micellar chromatography (BMC) system using Brij-35 mobile phases. The adequacy of the QRAR models developed is due to the fact that both…

A multi-methodology and sustainability-supporting framework for implementation and assessment of a holistic building renovation

La ristrutturazione degli edifici in futuro dovrà essere condotta secondo una prospettiva più olistica legata alla sostenibilità vista in una più ampia gamma di obiettivi/criteri e facilitata dagli scenari di ristrutturazione possibili. La ristrutturazione degli edifici dovrebbe servire a migliorarne le performance al fine di soddisfare le esigenze degli utenti, rendendo questi ultimi meno vulnerabili in relazione ai futuri costi energetici. Vi è un grande potenziale per ridurre il consumo di energia negli edifici esistenti. Tuttavia, ciò non deve comprometterè i valori architettonici e di qualità che rendono particolari. Pertanto, non possono essere semplicemente rinnovati, ma devono subir…

Aquaculture in Sicily: the state of the art

2009

Aquaculture in Sicily, represented almost exclusively by seabass and sea bream production, together with capture fishery, plays a significant role in the regional economy. On a national basis, the regional production covers about 20% of Italian euryha- line fish production. Fingerling supply is guaranteed by the two hatcheries present on the Island. Twelve floating cage farms and two inshore farms annually produce about 4,000 t of fish. A small extensive production arises from the storage basins of the salt work of Trapani. This niche production could represent an opportunity to realize a new distinctive organic aquaculture, preferred by the consumers respect to intensive produced fish, tha…