Clinical cardiac assessment in newborns with prenatally diagnosed intrathoracic masses

6533b839fe1ef96bd12a669a

RESEARCH PRODUCT

Clinical cardiac assessment in newborns with prenatally diagnosed intrathoracic masses

Giovanni Corsello Giuseppa Pinello Maria Clara Leone Ettore Piro Ingrid Anne Mandy Schierz Mario Giuffrè

subject

Prenatal Diagnosi Male Cardiomyopathy Cardiovascular abnormalities Congenital diaphragmatic hernia Cohort Studies Electrocardiography 0302 clinical medicine Retrospective Studie Prenatal Diagnosis Respiratory system abnormalities Diaphragmatic hernia 030219 obstetrics & reproductive medicine Respiratory distress Cardiovascular abnormalitie Ultrasound Clinical course lcsh:RJ1-570 Prognosis Survival Rate Retrospective study Cardiology Female Human Heart Defects Congenital medicine.medical_specialty Prognosi Risk Assessment Ultrasonography Prenatal 03 medical and health sciences Pulmonary hypoplasia 030225 pediatrics Internal medicine medicine Humans Abnormalities Multiple Retrospective Studies Respiratory Distress Syndrome Newborn business.industry Research Infant Newborn Respiratory system abnormalitie Congenital diaphragmatic hernia Ultrasonography Doppler Retrospective cohort study lcsh:Pediatrics medicine.disease Cohort Studie Hernias Diaphragmatic Congenital business

description

Abstract Background Congenital space-occupying thoracic malformations and diaphragmatic hernia have in common pulmonary hypoplasia. Our study aims to assess cardiac involvement during post-natal adaptation. Methods A retrospective study was carried out on newborns with prenatally diagnosed intrathoracic mass. Gathering for respiratory distress syndrome (RDS), 35 neonates were compared for clinical course, cardiovascular enzymes, ECG, and ultrasound. Results The analysis revealed a high left heart defect rate in patients with severe RDS, without being influenced by the laterality. Ultrasound or laboratory assessment did not detect altered cardiac dimension or cardiomyopathy. Solely ECG signs of right ventricular strain were found. Increased QT-dispersion, T-wave and cardiac variability alterations in the first hours were all expression of non-specific cardiac repolarization disorders but predict worse outcome. Conclusions Although RDS is the predominant symptom, slight cardiac dysfunctions should be recognized for prompt treatment. Conventional examinations for postnatal adaption should be integrated by complementary investigations.

year	journal	country	edition	language
2018-08-22	Italian Journal of Pediatrics

10.1186/s13052-018-0543-4 http://link.springer.com/article/10.1186/s13052-018-0543-4