Search results for "Systemic."
showing 10 items of 756 documents
Gender representation in authorship in later-phase systemic clinical trials in biliary tract cancer (BTC).
2021
348 Background: The proportion of females in medicine is increasing (approx. 50% in medical school/workforce), but disparities in female authorship in oncology research publications exist; female corresponding authorship reportedly ranges from 7.2-39.1% in oncology clinical trials (Ludmir et al 2019). This study aimed to describe and assess factors associated with female first and senior authorship in later phase systemic clinical trials in BTC and to identify any changes over time. Methods: Embase/Medline were used to identify final primary trial publications in BTC (2000-2020) (excluding phase I (PI) (expected to move to later phase), mixed tumour site trials, reviews, editorials and tri…
Panel Summary: Knowledge Model Representations
1997
Following the usual classifications of cognitive psychologists, we can say that the problem of representation spans three domains: the environment, the brain, and cognitive processes, which are usually studied by different scientists: the physicists, the neurobiologists and the psychologists. With the development of computer science and artificial intelligence new approaches have been introduced, which make possible simulation and implementation of cognitive processes through neural networks and symbolic systems. But the contribution of new methods is not limited to simulation, because they try to provide new models which consider cognitive process as information processing, not as reaction…
Imitation Learning and Anchoring through Conceptual Spaces
2007
In order to have a robotic system able to effectively learn by imitation and not merely reproduce the movements of a human teacher, the system should have the capability to deeply understand the perceived actions to be imitated. This paper deals with the development of a cognitive architecture for learning by imitation in which a rich conceptual representation of the observed actions is built. The purpose of the following discussion is to show how the same conceptual representation can be used both in a bottom-up approach, in order to learn sequences of actions by imitation learning paradigm, and in a top-down approach, in order to anchor the symbolical representations to the perceptual act…
Knowledge representation for robotic vision based on conceptual spaces and attentive mechanisms
1995
A new cognitive architecture for artificial vision is proposed. The architecture is aimed for an autonomous intelligent system, as several cognitive hypotheses have been postulated as guidelines for its design. The design is based on a conceptual representation level between the subsymbolic level processing the sensory data, and the linguistic level describing scenes by means of a high-level language. The architecture is also based on the active role of a focus of attention mechanism in the link between the conceptual and the linguistic level. The link between the conceptual level and the linguistic level is modelled as a time-delay attractor neural network.
Preclinical models for colonic absorption, application to controlled release formulation development.
2018
Oral controlled release (CR) formulations have many benefits and have become a valuable resource for the local and systemic administration of drugs. The most important characteristic of these pharmaceutical products is that drug absorption occurs mainly in the colon. Therefore, this review analyses the physiological and physicochemical features that may affect an orally administered CR product, as well as the different strategies to develop a CR dosage form and the methods used to evaluate the formulation efficacy. The models available to study the intestinal permeability and their applicability to colonic permeability determinations are also discussed.
The Development of Spatial Location in Finnish
1991
Abstract The purpose of this research was to study the shift from mono- to bi-referential spatial location in the language of Finnish children. Monoreferential location is based on the intrinsic properties of a referent object and the proximity relationship, and bireferential location requires coordinated spatial relationships involving referent objects and a projective relationship. Locative expressions which are monoreferential include: in/on/under and intrinsic front/back, and those which are bireferential include deictic front/back and between. A pictorial representation of locative relationships with a sentence-picture matching task was used to present the mono- vs bi-referential contr…
Evidence for the presence of autoantibodies to the collagen-like portion of C1q in systemic lupus erythematosus.
1988
We investigated the connection between the C1q solid-phase binding assay (C1q SPBA) and double-stranded DNA antibodies, and analyzed the immune complex material in systemic lupus erythematosus (SLE) sera. Comparison with a new monoclonal assay for C1q-bearing immune complexes (the 242G3 assay) revealed that the immune complexes in SLE bind specifically to solid-phase C1q, and not to fluid-phase C1q. The C1q solid-phase binding activity sedimented as 7S IgG, was insensitive to DNase treatment, and could be selectively absorbed by C1q-coupled beads and by bovine serum albumin-anti-bovine serum albumin C1q beads, but not by DNA. Thus, antibodies to double-stranded DNA do not interfere in the C…
Editorial Note The path of complexity science: from theory to managerial practice
2012
The application of complexity science to business has always been a diicult task because it is not easy to demonstrate the relevance of complexity theories to practicing managers. We accepted this challenge with this Special Issue, and I think we are giving a good con- tribution in this sense.
Temporal Binding in Multisensory and Motor-Sensory Contexts: Toward a Unified Model
2021
Our senses receive a manifold of sensory signals at any given moment in our daily lives. For a coherent and unified representation of information and precise motor control, our brain needs to temporally bind the signals emanating from a common causal event and segregate others. Traditionally, different mechanisms were proposed for the temporal binding phenomenon in multisensory and motor-sensory contexts. This paper reviews the literature on the temporal binding phenomenon in both multisensory and motor-sensory contexts and suggests future research directions for advancing the field. Moreover, by critically evaluating the recent literature, this paper suggests that common computational prin…
Time in Associative Learning: A Review on Temporal Maps
2021
Ability to recall the timing of events is a crucial aspect of associative learning. Yet, traditional theories of associative learning have often overlooked the role of time in learning association and shaping the behavioral outcome. They address temporal learning as an independent and parallel process. Temporal Coding Hypothesis is an attempt to bringing together the associative and non-associative aspects of learning. This account proposes temporal maps, a representation that encodes several aspects of a learned association, but attach considerable importance to the temporal aspect. A temporal map helps an agent to make inferences about missing information by applying an integration mechan…