Search results for "T1"
showing 10 items of 587 documents
Relationship among Perceived Dynamism, Technological Posture and Innovation Performance
2014
A main strategic election for a firm is its technological posture, which can be understood as its propensity to innovate and the moment for the introduction of technological changes into the market. This paper, which focuses on the renewable energy industry in Spain, establishes that in environments in which dynamism is understood by managers as high, and the appreciation of change is greater, firms develop a greater tendency towards technological leadership postures (pioneer or first-mover strategy) rather than conservative or follower postures (last-mover strategy). The results of the analysis, carried out through a structural equation model based on the partial least squares (PLS) techni…
Validação de um questionário de satisfação sobre a formação prática de estudantes de enfermagem
2019
Objetivo: validar un instrumento para valorar la formación práctica y la satisfacción con las asignaturas de Practicum de los estudiantes de Enfermería. Método: estudio observacional, descriptivo, transversal (curso 2014-2015). Validación de un cuestionario autoadministrado y anónimo (17 ítems) de Satisfacción sobre el Practicum en Estudiantes de Enfermería, elaborado por consenso de ocho expertos en formación práctica (en tres sesiones de grupo nominal). Se realizó análisis factorial y confirmatorio, estimándose la consistencia interna para determinar su validez. Se calculó la satisfacción de los estudiantes en cada asignatura y en su totalidad. Resultados: 174 respuestas. Alta correlación…
The Large Observatory for X-ray Timing (LOFT)
2012
High-time-resolution X-ray observations of compact objects provide direct access to strong-field gravity, to the equation of state of ultra-dense matter and to black hole masses and spins. A 10 m^2-class instrument in combination with good spectral resolution is required to exploit the relevant diagnostics and answer two of the fundamental questions of the European Space Agency (ESA) Cosmic Vision Theme "Matter under extreme conditions", namely: does matter orbiting close to the event horizon follow the predictions of general relativity? What is the equation of state of matter in neutron stars? The Large Observatory For X-ray Timing (LOFT), selected by ESA as one of the four Cosmic Vision M…
Interviews with Community Healthcare Registered Nurses in Norway: Examination Practices and Clinical Evaluation Processes
2021
Abstract Aim This study describes the examination practices and clinical evaluation processes that Registered Nurses in Norway perform in the community healthcare sector. Design A qualitative exploratory design. Methods Twenty interviews were conducted with Registered Nurses employed in the community healthcare sector in Norway. The data were analysed using a thematic analysis. Results We found four major themes: (1) evaluations are embedded in nurses’ daily work, (2) significance of a Registered Nurse's clinical competency, (3) different tasks require various roles and (4) access to resources and equipment. Registered Nurses possess several skills in a range of different examination techni…
Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
2014
Abstract Mitochondrial dysfunctions accompany several neurodegenerative disorders and contribute to disease pathogenesis among others in Parkinson’s disease (PD). Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a major regulator of mitochondrial functions and biogenesis, and was suggested as a therapeutic target in PD. PGC-1α is regulated by both transcriptional and posttranslational events involving also the action of growth factors. Fibroblast growth factor-21 (FGF21) is a regulator of glucose and fatty acid metabolism in the body but little is known about its action in the brain. We show here that FGF21 increased the levels and activity of PGC-1α and elevated mito…
Neuronal FGFR1 transactivation by inducing FGFR1/5-HT1A heteroreceptor complexes formation
2011
There are no clear data on the molecular mechanism by which the hippocampal 5-HT transmission contributes to the neuroprotective and antidepressant effects of 5-HT uptake blockers. Previously, we revealed that a 5-HT1A agonist may induce phosphorylation of FGFR1 and ERK1/2 in rat hippocampus independent of FGF-2, suggesting transactivation of FGFR1 tyrosine kinase in the absence of neurotrophic factor binding. As extension of previous work, using BRET analysis and coimmunoprecipitation in cellular models, FGFR1-5-HT1A heteroreceptor complexes have been demonstrated and agonist modulation characterized. In vitro assays on ERK1/2 phosphorylation in HEK cells and primary hippocampal cultures h…
Linear density-based clustering with a discrete density model
2018
Density-based clustering techniques are used in a wide range of data mining applications. One of their most attractive features con- sists in not making use of prior knowledge of the number of clusters that a dataset contains along with their shape. In this paper we propose a new algorithm named Linear DBSCAN (Lin-DBSCAN), a simple approach to clustering inspired by the density model introduced with the well known algorithm DBSCAN. Designed to minimize the computational cost of density based clustering on geospatial data, Lin-DBSCAN features a linear time complexity that makes it suitable for real-time applications on low-resource devices. Lin-DBSCAN uses a discrete version of the density m…
Time Difference of Arrival Estimation from Frequency-Sliding Generalized Cross-Correlations Using Convolutional Neural Networks
2020
The interest in deep learning methods for solving traditional signal processing tasks has been steadily growing in the last years. Time delay estimation (TDE) in adverse scenarios is a challenging problem, where classical approaches based on generalized cross-correlations (GCCs) have been widely used for decades. Recently, the frequency-sliding GCC (FS-GCC) was proposed as a novel technique for TDE based on a sub-band analysis of the cross-power spectrum phase, providing a structured two-dimensional representation of the time delay information contained across different frequency bands. Inspired by deep-learning-based image denoising solutions, we propose in this paper the use of convolutio…
INHIBITION OF FATTY ACID DESATURASES INDrosophila melanogasterLARVAE BLOCKS FEEDING AND DEVELOPMENTAL PROGRESSION
2016
International audience; Fatty acid desaturases are metabolic setscrews. To study their systemic impact on growth in Drosophila melanogaster, we inhibited fatty acid desaturases using the inhibitor CAY10566. As expected, the amount of desaturated lipids is reduced in larvae fed with CAY10566. These animals cease feeding soon after hatching, and their growth is strongly attenuated. A starvation program is not launched, but the expression of distinct metabolic genes is activated, possibly to mobilize storage material. Without attaining the normal size, inhibitor-fed larvae molt to the next stage indicating that the steroid hormone ecdysone triggers molting correctly. Nevertheless, after moltin…
Gene Regulation and Species-Specific Evolution of Free Flight Odor Tracking in Drosophila
2018
Running title: flight evolution in Drosophila This is an invited contribution to the special issue on Genetics of Adaptation based on a symposium of the same name at the National Centre for Biological Sciences (TIFR, Bangalore, India) in November 2016; International audience; The flying ability of insects has coevolved with the development of organs necessary to take-off from the ground, generate, and modulate lift during flight in complex environments. Flight orientation to the appropriate food source and mating partner depends on the perception and integration of multiple chemical signals. We used a wind tunnel-based assay to investigate the natural and molecular evolution of free flight …