Search results for "T1"
showing 10 items of 587 documents
A key pathogenic role for the STAT1/T-bet signaling pathway in T-cell-mediated liver inflammation.
2003
TH1 cytokines have been suggested to contribute to the pathogenesis of T-cell-mediated liver injury and inflammation. However, the molecular signaling pathways involved in such injury are still poorly understood. In the present study, we investigated the role of the STAT1/T-bet signaling pathway in a murine model of T-cell-mediated liver inflammation induced by the application of concanavalin A (Con A) using newly created STAT1 transgenic mice as well as STAT1- and T-bet-deficient mice. Liver injury induced by Con A was associated with an increase of both pSTAT1 and T-bet levels in the liver. Furthermore, functional studies suggested a pathogenic role for STAT1 in Con A-induced liver injury…
Predominance of the fimH30 Subclone Among Multidrug-Resistant Escherichia coli Strains Belonging to Sequence Type 131 in Italy
2013
Systematic screening for mutations in the promoter and the coding region of the 5-HT1A gene.
1995
In the present study we sought to identify genetic variation in the 5-HT{sub 1A} receptor gene which through alteration of protein function or level of expression might contribute to the genetic predisposition to neuropsychiatric diseases. Genomic DNA samples from 159 unrelated subjects (including 45 schizophrenic, 46 bipolar affective, and 43 patients with Tourette`s syndrome, as well as 25 healthy controls) were investigated by single-strand conformation analysis. Overlapping PCR (polymerase chain reaction) fragments covered the whole coding sequence as well as the 5{prime} untranslated region of the 5-HT{sub 1A} gene. The region upstream to the coding sequence we investigated contains a …
Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells
2012
Abstract Background Aneuploidy has been acknowledged as a major source of genomic instability in cancer, and it is often considered the result of chromosome segregation errors including those caused by defects in genes controlling the mitotic spindle assembly, centrosome duplication and cell-cycle checkpoints. Aneuploidy and chromosomal instability has been also correlated with epigenetic alteration, however the molecular basis of this correlation is poorly understood. Results To address the functional connection existing between epigenetic changes and aneuploidy, we used RNA-interference to silence the DNMT1 gene, encoding for a highly conserved member of the DNA methyl-transferases. DNMT1…
DETERMINATION OF THE IMPACTS OF LAND USE CHANGE ON WATER BASIN USING REMOTE SENSING AND GEOGRAPHICAL INFORMATION SYSTEM
2016
The population has been increasing as a result of mass immigration in Istanbul. An urbanization process continues and it causes serious increases in urban areas while decreasing the amount of natural environment. This uncontrolled and illegal urbanization accompanied by insufficient infrastructure has caused degradation of cropland and forested areas in the metropolitan area, especially in water basin area. The watershed basins inside the metropolitan area have accelerated the land-cover changes, which have negative impacts on water quality of the basins. The Terkos water basin, one of the seven water basins of Istanbul providing drinking water, was selected as a study area. In order to und…
Reliability Analysis of a Controlled Stage-Constructed and Reinforced Embankment on Soft Ground Using 2D and 3D Models
2020
Geosynthetic reinforcement has become a very practical technique to improve geotechnical structure safety. In spite of improved soil behavior, structures are affected by uncertainties related to soil and reinforcement material properties. This paper aims to present a reliability analysis in order to take statistical information (uncertainties) into account in a safety analysis of reinforced embankments. The analysis was used in a case study on a controlled stage-constructed embankment on soft ground in order to investigate its probabilistic stability. Modeling was performed by commercial geotechnical software usage (GeoStudio and RocScience packs, SIGMA/W+SLOPE/W and SLIDE³, respectively) a…
Psychometric Evaluation of Nursing Professionals Involved in Palliative Care
2017
12 páginas Objetivos: Validar las escalas de Bienestar Psicológico de Ryff en enfermería y relacionarlas con variables clave en calidad de vida laboral. Materiales y método: participaron por encuesta electrónica autoadministrada anónima 433 profesionales, 33.1% profesionales de enfermería (n=123) en quienes nos centramos. Además de sociodemográficos, se recogió información sobre bienestar psicológico, atención consciente, afrontamiento de la muerte y calidad de vida. La validez de constructo fue evaluada con análisis factorial confirmatorio. Se estimó fiabilidad y se recogieron evidencias de validez externa. Resultados: El modelo mostró ajuste adecuado: c2(362) = 438.59 (p = .01), CFI = .98…
Family burden, social support and community health in caregivers of people with serious mental disorder
2018
RESUMEN Objetivo Identificar el nivel de sobrecarga de los cuidadores y analizar los factores asociados con el cuidado familiar en salud mental. Método Se realizó un estudio descriptivo transversal realizado entre los meses de enero y julio del año 2016, en el que se evalúa una muestra de cuidadores de siete dispositivos públicos y una asociación de familiares y pacientes identificando la sobrecarga de los mismos y los factores que contribuyen a reducir estos niveles, a través del instrumento Zarit Burden Inventor y . El estudio se llevó a cabo de acuerdo a las recomendaciones de los comités de ética de las instituciones participantes. Resultados Participaron 107 cuidadores. Las principales…
Tourisme Sportif et Identités : Les pratiquants de canoë en Zambie
2013
Cet article repose sur une enquête sur les usages sociaux du canoë en Zambie. Il a pour objectif de décrire les caractéristiques des relations sociales qui se nouent entre étrangers et « populations locales ». Si l’organisation de l’activité recouvre une visée touristique pour nombre de pays africains, touristes et habitants entrent peu en interaction en dehors de la pratique des loisirs. Pour étudier l’identité, il s’agit de caractériser la genèse du tour en canoë afin de saisir l’émergence de modes d’appréhension de l’Autre dans le cadre du loisir en Zambie. La singularité des relations sociales entre populations occidentales et africaines pose la question de la différence culturelle, au …
Prevención de úlceras por presión en neonatos con ventilación mecánica no invasiva
2020
espanolRESUMEN Objetivo: Determinar el aposito con mayor efectividad (hidrocoloide o espuma de poliuretano) en neonatos ingresados en las unidades de cuidados intensivos neonatal y pediatrica del Hospital Clinico Universitario de Valencia, sometidos a ventilacion mecanica no invasiva para la prevencion de ulceras por presion nasales y/o faciales. Material y metodos: Proyecto de investigacion de tipo observacional, prospectivo y analitico cuya muestra estaba formada por 13 neonatos con ventilacion mecanica no invasiva, hospitalizados en la unidad de cuidados intensivos neonatales y pediatrica. Los neonatos fueron divididos en dos grupos: en el grupo A (7 pacientes) se empleo el aposito de es…