Search results for "TAGL"
showing 10 items of 296 documents
Prostaglandin E(2)-loaded microspheres as strategy to inhibit phagocytosis and modulate inflammatory mediators release.
2008
PGE(2), an arachidonic acid metabolite produced by various type of cells regulates a broad range of physiological activities in the endocrine, cardiovascular, gastrointestinal, and immune systems, and is involved in maintaining the local homeostasis. In the immune system, PGE(2) is mainly produced by APCs and it can suppress the Th1-mediated immune responses. The aim of this study was to develop PGE(2)-loaded biodegradable MS that prolong and sustain the in vivo release of this mediator. An o/w emulsion solvent extraction-evaporation method was chosen to prepare the MS. We determined their diameters, evaluated the in vitro release of PGE(2), using enzyme immunoassay and MS uptake by periton…
Lipid and fatty acid variations inCiona intestinalis ovary after tri-n-butyltin(IV)chloride exposure
2005
Reduction of total lipids (TL) content and significant variations of triglyceride (TG) and phospholipid (PL) fractions were observed as a consequence of exposure of Ciona intestinalis ovaries to tributyltin chloride (TBTCL) solutions. In particular, an evident TG decrease and a PL increase were observed, which probably provoked an increment in membrane fluidity, because of the high concentration of long chain fatty acids and, as a consequence, PL. This could be a cell adaptive standing mechanism towards the pollutants, as observed in Saccharomyces cerevisiae. Also the increase in the content of the polyunsaturated fatty acids (PUFA), important in the synthesis of compounds such as prostagla…
Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E2 production in osteoarthritic chondrocytes
2009
Pro-inflammatory cytokines such as interleukin-1beta (IL-1beta) may participate in the pathogenesis of cartilage damage in osteoarthritis (OA) through the production of catabolic enzymes and inflammatory mediators. Induction of heme oxygenase-1 (HO-1) has previously been shown to exert anti-inflammatory effects in different cell types. We have investigated whether HO-1 induction may modify chondrocyte viability and the production of relevant mediators such as oxidative stress and prostaglandin E(2) (PGE(2)) elicited by IL-1beta in OA chondrocytes. Chondrocytes were isolated from OA cartilage and used in primary culture. Cells were stimulated with IL-1beta in the absence or presence of the H…
Cyclo-oxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs
1997
International audience; The discovery of at least 2 cyclo-oxygenase (COX) isoenzymes, referred to as COX-1 and COX-2, has updated our knowledge of nonsteroidal anti-inflammatory drugs (NSAIDs). This has lead investigators to reconsider what can be awaited from this class of drugs. The 2 COX isoenzymes share structural and enzymatic similarities, but are specifically regulated at the molecular level and may be distinguished apart in their functions, although some physiological overlap between them does occur. The major goal in developing selective COX inhibitors is to improve NSAID tolerability. Classic NSAIDs preferentially inhibit COX-1 in vitro, but it appears hazardous to judge their gas…
Le détail à ossature métallique. La préfabrication en acier des années 1930: nouvelles pratiques de conception.
2007
Caratterizzazione geotecnica di un’argilla trattata con calce posta in rilevato
2015
Nelle nota si presentano alcuni risultati di un’indagine di laboratorio eseguita su campioni indisturbati prelevati da un rilevato sperimentale, realizzato trattando con calce i terreni argillosi provenienti dallo scavo di una vicina galleria artificiale. La ricerca è stata sviluppata nell'ambito dei lavori di ammodernamento della S.S. 640 tra Agrigento e Caltanissetta. I risultati, oltre ad evidenziare gli usuali effetti derivanti dalle modifiche delle caratteristiche geotecniche dell’argilla indotti dai processi di stabilizzazione con calce, consentono di evidenziare alcune peculiarità del comportamento meccanico delle argille trattate.
CARATTERIZZAZIONE GEOTECNICA DI UN’ARGILLA DI ALTA PLASTICITAꞌ TRATTATA CON CALCE
2013
Nel corso dei lavori di ammodernamento di una strada di grande comunicazione in Sicilia, si è valutata la possibilità di utilizzare come materiale di costruzione un’argilla di alta plasticità trattata con calce, proveniente dagli scavi eseguiti in una parte del tracciato. A questo scopo è stata avviata un’estesa ricerca sperimentale in laboratorio e sono state verificate le condizioni di posa in opera del materiale con la realizzazione di un rilevato sperimentale. Nella nota si illustrano i primi risultati della ricerca riguardanti: prove di taglio diretto, prove di compressione ad espansione laterale libera e misure di suzione.
Apparati
2011
Amato, Giacomo: 32, 33. Basile, Ernesto: 17, 150, 161, 164, 170 nota 64, 171 nota 79, 172 nota 87. Basta, Scipione: 29, 30, 45 nota 47, 46 e ivi nota 51. Bocia, Innocenzo (anche Innocensus): 77. Boito, Camillo: 17. Cascione, Giovan Battista: 31, 32, 34. Chenchi, Carlo: 91, 93, 100 nota 77. Chiavetta Gaetano (anche Caietanus Chivetto): 77, 87.
Antioxidant and Antiinflammatory Properties of Heme Oxygenase-1 in Osteoarthritic Articular Cells
2012
Heme oxygenase-1 (HO-1) is induced in cells by various stimuli as a defense system against oxidative stress. It is known that reactive oxygen species (ROS) participates in the initiation and progression of osteoarthritis (OA) and several antioxidant systems may protect cartilage components. HO-1 induction or CO release from CORM-2 counteracts oxidative stress and protects against proinflammatory and catabolic effects of interleukin-1β in OA chondrocytes, osteoblasts, and synoviocytes as well as in OA osteochondral explants. Both approaches have been able to downregulate the production of mediators such as reactive oxygen species, nitric oxide, matrix metalloproteinases, prostaglandin E2, cy…
Depressed Prostaglandin Release from Peritoneal Cells Induced by a T Cell Adjuvant, Lentinan
1979
Abstract PGE and PGF release from peritoneal exudate cells was studied in mice after injection with two s (1–3) glucans, the antitumor active lentinan and the inactive pachyman. 4 days after injection of both polysaccharides, the spontaneous and phagocytosis-induced PGE and PGF release was markedly suppressed. However, only the immunopotentiator lentinan induced peritoneal exudate cells which exhibited a longer lasting diminished PG release. The data suggest that the T cell adjuvant lentinan may potentiate cellular immune responses by reducing synthesis of immune suppressive prostaglandins from peritoneal exudate cells.