Search results for "TAU"

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

2018

Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health.Methods: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n= 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult s…

Modern taurine cattle descended from small number of near-eastern founders.

2012

Archaeozoological and genetic data indicate that taurine cattle were first domesticated from local wild ox (aurochs) in the Near East some 10,500 years ago. However, while modern mitochondrial DNA (mtDNA) variation indicates early Holocene founding event(s), a lack of ancient DNA data from the region of origin, variation in mutation rate estimates, and limited application of appropriate inference methodologies have resulted in uncertainty on the number of animals first domesticated. A large number would be expected if cattle domestication was a technologically straightforward and unexacting region-wide phenomenon, while a smaller number would be consistent with a more complex and challengin…

Starptautiskie noziegumi un to attaisnošana

2015

Starptautiskie noziegumi un to attaisnošana ir problēma, ar kuru saskaras liela daļa pasaules valstu. Uz to norāda tas, ka aizvien vairāk valstu izvēlas kriminalizēt konkrētu starptautisku noziegumu attaisnošanu. Īpaši šī problēma ir jūtama tajās valstīs, kuras pašas vai tās iedzīvotāji, ir cietuši no starptautiskajiem noziegumiem, kā piemēram, Latvija, Lietuva, Ruanda, Armēnija un citas valstis. Autors darbā ir izpētījis starptautiskos noziegumus un to veidus, Krimināllikuma 741.pantā iekļautā noziedzīgā nodarījuma sastāvu, kā arī ārvalstu regulējumu starptautisko noziegumu attaisnošanā un to praksi šajā jautājumā. Atslēgvārdi: genocīds, noziegumi pret cilvēci, kara noziegumi, noziegumi pr…

A new species of Centaurea (Asteraceae) from Calabria(S Italy)

2013

A new species is described here from the Presila in Calabria (S Italy) and named Centaurea calabra. It belongs to Centaurea sect. Phalolepis and is related to the C. deusta group, namely to C. sarfattiana. Taxonomical characteristics, distribution, and ecology of the new Centaurea are also provided.

Centaurea heywoodiana (Asteraceae), a new species from the Nebrodi Mountains (NE-Sicily)

2020

A new endemic species of Centaurea is here described from the Nebrodi Mountains, in Sicily, and named Centaurea heywoodiana. Information on its morphology, distribution, ecology and taxonomic relationship is also provided.

Роль Академической библиотеки Латвийского Университета в развитии научных и культурных взаимоотношений Латвии и Грузии

2015

The activities and participation categories of the ICF Core Sets for multiple sclerosis from the patient perspective.

2013

Purpose: To validate the activities and participation components of The International Classification of Functioning, Disability and Health (ICF). Methods: In this cross-sectional study, 113 Finnish community-dwelling persons with MS were assessed using a semi-structured interview provided by the Canadian Occupational Performance Measure (COPM) to capture participants’ self-perceived problems in everyday activities and participation. Problems were linked to the ICF categories. Results: Participants identified 527 of the most important occupational performance problems. They covered all chapters of the ICF Activities and Participation components. Forty-one categories out of a total 53 ICF act…

Towards a physically more active lifestyle based on one's own values: study design of a randomized controlled trial for physically inactive adults

2013

Background This randomised controlled trial demonstrates the effectiveness of a value-based intervention program to encourage a physically more active lifestyle among physically inactive adults aged 30 to 50 years. The conceptual framework of the program is based on an innovative behavioural therapy called Acceptance and Commitment Therapy (ACT) that aims to increase an individual’s psychological flexibility and support behaviour change towards a higher quality and more meaningful life. Methods Participants will be randomly allocated to a feedback group (FB) or an Acceptance and Commitment based (ACT + FB) group. Both the groups will receive written feedback about their objectively measured…

Physical exercise in the prevention and treatment of Alzheimer's disease

2020

Highlights • Low levels of physical activity are a risk factor associated with Alzheimer's disease. • Older adults who exercise are more likely to maintain cognition. • Exercise modulates amyloid β turnover, inflammation, synthesis, and release of neurotrophins, and cerebral blood flow.

Differences in cardiometabolic risk profiles between Chinese and Finnish older adults with glucose impairment and central obesity.

2022

Abstract Background Obesity and ethnicity play important roles in cardiovascular complications in patients with type 2 diabetes mellitus (T2DM). This study aimed to compare cardiometabolic risk profiles between Chinese and Finnish older adults of central obesity with prediabetes or T2DM. Methods Study subjects were 60–74 years old and originated from two population samples. The Finnish subjects came from the Kuopio Ischemic Heart Disease (KIHD) study (n = 1089), and the Chinese subjects came from the Shanghai High-risk Diabetic Screen (SHiDS) study (n = 818). The KIHD and SHiDS studies used similar questionnaires to determine participants’ baseline characteristics regarding the history of m…