Search results for "TECNOLOGICO"
showing 10 items of 440 documents
Polyaspartamide-g-Polylactide graft cpolymers able to form nanoparticles obtained by a novel synthetic strategy.
2009
Glycosylated macromolecular conjugates of antiviral drugs with a polyaspartamide.
2004
Two new polymeric conjugates for specific liver targeting were prepared by conjugation of sugar moieties and antiviral drugs to alpha, beta-poly[N-2-(hydroxyethyl)-DL-aspartamide] (PHEA). PHEA-galactopyranosylphenylthiocarbamide-mono-O-succinylganciclovir (conjugate 7) and PHEA-mannopyranosylphenylthiocarbamide-O-succinylacyclovir (conjugate 8) were synthesized according to a multi-step procedure which allowed for obtaining high product yield and process standardization. Conjugate 7 contained 7.5 and 8.5% of galactose and ganciclovir (substituent/repeating unit, mol/mol), respectively, and conjugate 8 contained 14.2 and 10.8% of mannose and acyclovir, respectively. In vitro studies demonstr…
DRUG DELIVERY FROM MUCOADHESIVE DISKS BASED ON A PHOTO-CROSS-LINKABLE POLYASPARTAMIDE DERIVATIVE
2005
Disks for local delivery of amoxicillin to the buccal or gastric cavity were prepared using as starting polymer a polyaspartamide derivative. In particular, α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) was derivatized with glycidyl methacrylate (GMA) in order to synthesize PHG, a photo-cross-linkable and biodegradable polymer that gives rise to the formation of a chemical hydrogel (PHG-UV) by UV irradiation. This hydrogel was shaped as disks whose mucoadhesive properties have been confirmed by swelling measurements in phosphate buffer/citric acid solution at pH 7.0 in the presence of various concentrations of mucin. Swelling ability of PHG-UV disks was also evaluated in simulated saliva…
NEW GUIDED BONE REGENERATION PROCEDURE USING LEUKOCYTE AND PLATELET RICH FIBRIN (L PRF) IN ORAL SURGERY
2021
Non-transfusional hemocomponents are autogenous products used in several surgical fields obtained by the centrifugation of a blood sample from a patient and able to promote hard and soft tissue regeneration, local haemostasis, and the acceleration of wound healing. The aim of this PhD thesis was the validation of an innovative protocol for the Guided Bone Regeneration (GBR) technique using second-generation autologous platelet concentrates, Leukocytes and Platelet-rich Fibrin (L-PRF), in post-extraction sockets of patients in need of dental avulsions and successive implant prosthetic rehabilitation, evaluating its ability to prevent alveolar bone resorption and promote bone regeneration. Th…
NEW BIODEGRADABLE HYDROGELS DESIGNED FOR COLONIC DRUG DELIVERY: IN VITRO RELEASE OF THE PEPTIDES GLUTATHIONE AND OXYTOCIN
2009
Hyaluronic acid based hydrogels for antibiotics and enzymes release: from academic research to industry
2016
Conclusion: HA-g-PDLLA hydrogel is suitable to coat a prosthesis remaining adherent to it and distributing itself in the bone cavity. The hydrogel has been proven effective in a rabbit model of highly contaminated implant. In vivo studies have demonstrated how the intraoperative coating of implants with DAC is safe and feasible. HA-EDA-MA hydrogel is able to protect PEP from alteration during storage and it seems a good candidate for a potential once-daily oral formulation in the treatment of celiac disease.
IDAC: production of resorbable hyaluronic acid hydrogels
2013
Arginine-Rich Peptidomimetic Ampicillin/Gentamicin Conjugate To Tackle Nosocomial Biofilms: A Promising Strategy To Repurpose First-Line Antibiotics
2023
: Combined therapy with penicillins and aminoglycosides has been proved beneficial to address many persistent bacterial infections with possible synergistic effects. However, the different pharmacokinetic profiles of these two antibiotic classes may not guarantee a concerted spatio-temporal delivery at the site of action, decreasing the efficacy of this combination and promoting resistance. Herein, we propose a multifunctional antibiotic-polymer conjugate, designed to colocalize ampicillin and gentamicin to tackle persistent biofilm infections. The two antibacterial molecules were grafted along with the amino acid l-arginine to a biocompatible polymer backbone with peptidomimetic hydrophili…
Innovazione e Imprenditorialità. Il ruolo degli spin-off universitari.
2013
Oggi il ruolo delle Università non si limita più soltanto alle tradizionali attività di formazione e di ricerca. La cosiddetta Seconda Rivoluzione Accademica ha attribuito alle Università una "terza missione", che consiste nella valorizzazione e commercializzazione della conoscenza accedemica sul mercato. L'Università diviene così "entrepreneurial university" creando valore non solo in termini di conoscenza ma anche di innovazione e sviluppo economico. Il libro intende approfondire il ruolo che le Università rivestono nel processo di trasferimento di conoscenza innovativa al mercato tramite la costituzione di imprese spin-off. Viene evidenziato come, attraverso il supporto di apposite strut…